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Anthrax infection

MedGen UID:
8110
•Concept ID:
C0003175
•
Disease or Syndrome
Synonyms: Anthrax; Black Baine; Malignant edema; Malignant pustule; Ragpicker's disease; Siberian Plague; Wool sorter's disease
SNOMED CT: Anthrax (409498004); Milzbrand (409498004); Infection due to Bacillus anthracis (409498004); Splenic fever (409498004); Charbon (409498004)
 
Monarch Initiative: MONDO:0005119

Definition

An infection caused by Bacillus anthracis bacteria. It may affect the lungs, gastrointestinal tract, or skin. Patients with lung infection present with fever, headaches, cough, chest pain and shortness of breath. Patients with gastrointestinal infection present with nausea, vomiting and bloody diarrhea. Patients with skin infection develop blisters and ulcers. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnthrax infection

Professional guidelines

PubMed

Antitoxin Use in the Prevention and Treatment of Anthrax Disease: A Systematic Review.
Hesse EM, Godfred-Cato S, Bower WA
Clin Infect Dis 2022 Oct 17;75(Suppl 3):S432-S440. doi: 10.1093/cid/ciac532. PMID: 36251559Free PMC Article
Does anthrax antitoxin therapy have a role in the treatment of inhalational anthrax?
Vietri NJ
Curr Opin Infect Dis 2018 Jun;31(3):257-262. doi: 10.1097/QCO.0000000000000446. PMID: 29570493
The prophylaxis and treatment of anthrax.
Brook I
Int J Antimicrob Agents 2002 Nov;20(5):320-5. doi: 10.1016/s0924-8579(02)00200-5. PMID: 12431866

Recent clinical studies

Etiology

An integrated model for anthrax-free zone development in developing countries.
Sarker MSA, Shahid MAH, Rahman MB, Nazir KHMNH
J Infect Public Health 2023 Dec;16 Suppl 1:141-152. Epub 2023 Oct 31 doi: 10.1016/j.jiph.2023.10.024. PMID: 37953112
Genetic diversity of Bacillus anthracis Ames lineage strains in China.
Zhang E, Zhang H, He J, Li W, Wei J
BMC Infect Dis 2020 Feb 14;20(1):140. doi: 10.1186/s12879-020-4867-5. PMID: 32059712Free PMC Article
Reversal of Newer Direct Oral Anticoagulant Drugs (DOACs).
Hussain SS, Tyroch AH, Mukherjee D
Cardiovasc Hematol Agents Med Chem 2017;14(2):76-81. doi: 10.2174/1871525714666160524144359. PMID: 27215215
Inhibitors of the Metalloproteinase Anthrax Lethal Factor.
Goldberg AB, Turk BE
Curr Top Med Chem 2016;16(21):2350-8. doi: 10.2174/1568026616666160413135732. PMID: 27072692Free PMC Article
Anthrax meningoencephalitis.
Lanska DJ
Neurology 2002 Aug 13;59(3):327-34. doi: 10.1212/wnl.59.3.327. PMID: 12177364

Diagnosis

Injectional anthrax in human: A new face of the old disease.
Zasada AA
Adv Clin Exp Med 2018 Apr;27(4):553-558. doi: 10.17219/acem/68380. PMID: 29533547
New insights into gastrointestinal anthrax infection.
Owen JL, Yang T, Mohamadzadeh M
Trends Mol Med 2015 Mar;21(3):154-63. Epub 2014 Dec 19 doi: 10.1016/j.molmed.2014.12.003. PMID: 25577136Free PMC Article
Anthrax infection.
Sweeney DA, Hicks CW, Cui X, Li Y, Eichacker PQ
Am J Respir Crit Care Med 2011 Dec 15;184(12):1333-41. Epub 2011 Aug 18 doi: 10.1164/rccm.201102-0209CI. PMID: 21852539Free PMC Article
Public health and bioterrorism: renewed threat of anthrax and smallpox.
Wallin A, Luksiene Z, Zagminas K, Surkiene G
Medicina (Kaunas) 2007;43(4):278-84. PMID: 17485954
Anthrax meningoencephalitis.
Lanska DJ
Neurology 2002 Aug 13;59(3):327-34. doi: 10.1212/wnl.59.3.327. PMID: 12177364

Therapy

Does anthrax antitoxin therapy have a role in the treatment of inhalational anthrax?
Vietri NJ
Curr Opin Infect Dis 2018 Jun;31(3):257-262. doi: 10.1097/QCO.0000000000000446. PMID: 29570493
Injectional anthrax in human: A new face of the old disease.
Zasada AA
Adv Clin Exp Med 2018 Apr;27(4):553-558. doi: 10.17219/acem/68380. PMID: 29533547
Anthrax lethal factor inhibitors as potential countermeasure of the infection.
Kumar BV, Malik S, Grandhi P, Dayam R, Sarma JA
Curr Top Med Chem 2014;14(17):1977-89. doi: 10.2174/1568026614666140929120231. PMID: 25262802
Anthrax infection.
Sweeney DA, Hicks CW, Cui X, Li Y, Eichacker PQ
Am J Respir Crit Care Med 2011 Dec 15;184(12):1333-41. Epub 2011 Aug 18 doi: 10.1164/rccm.201102-0209CI. PMID: 21852539Free PMC Article
Vaccines: countering anthrax: vaccines and immunoglobulins.
Grabenstein JD
Clin Infect Dis 2008 Jan 1;46(1):129-36. doi: 10.1086/523578. PMID: 18171228

Prognosis

Does anthrax antitoxin therapy have a role in the treatment of inhalational anthrax?
Vietri NJ
Curr Opin Infect Dis 2018 Jun;31(3):257-262. doi: 10.1097/QCO.0000000000000446. PMID: 29570493
Anthrax lethal and edema toxins in anthrax pathogenesis.
Liu S, Moayeri M, Leppla SH
Trends Microbiol 2014 Jun;22(6):317-25. Epub 2014 Mar 27 doi: 10.1016/j.tim.2014.02.012. PMID: 24684968Free PMC Article
Anthrax lethal toxin and the induction of CD4 T cell immunity.
Ascough S, Ingram RJ, Altmann DM
Toxins (Basel) 2012 Oct;4(10):878-99. Epub 2012 Oct 19 doi: 10.3390/toxins4100878. PMID: 23162703Free PMC Article
Inhalational, gastrointestinal, and cutaneous anthrax in children: a systematic review of cases: 1900 to 2005.
Bravata DM, Holty JE, Wang E, Lewis R, Wise PH, McDonald KM, Owens DK
Arch Pediatr Adolesc Med 2007 Sep;161(9):896-905. doi: 10.1001/archpedi.161.9.896. PMID: 17768291
Anthrax meningoencephalitis.
Lanska DJ
Neurology 2002 Aug 13;59(3):327-34. doi: 10.1212/wnl.59.3.327. PMID: 12177364

Clinical prediction guides

Host Cell Transcriptional Tuning with CRISPR/dCas9 to Mitigate the Effects of Toxin Exposure.
Metzger D, Miller K, Lyon W, Migliozzi R, Pangburn HA, Saldanha R
ACS Synth Biol 2022 Nov 18;11(11):3657-3668. Epub 2022 Nov 1 doi: 10.1021/acssynbio.2c00214. PMID: 36318971
Genetic diversity of Bacillus anthracis Ames lineage strains in China.
Zhang E, Zhang H, He J, Li W, Wei J
BMC Infect Dis 2020 Feb 14;20(1):140. doi: 10.1186/s12879-020-4867-5. PMID: 32059712Free PMC Article
A Biologically-Based Computational Approach to Drug Repurposing for Anthrax Infection.
Bai JP, Sakellaropoulos T, Alexopoulos LG
Toxins (Basel) 2017 Mar 10;9(3) doi: 10.3390/toxins9030099. PMID: 28287432Free PMC Article
Anthrax lethal toxin and the induction of CD4 T cell immunity.
Ascough S, Ingram RJ, Altmann DM
Toxins (Basel) 2012 Oct;4(10):878-99. Epub 2012 Oct 19 doi: 10.3390/toxins4100878. PMID: 23162703Free PMC Article
Inhalational, gastrointestinal, and cutaneous anthrax in children: a systematic review of cases: 1900 to 2005.
Bravata DM, Holty JE, Wang E, Lewis R, Wise PH, McDonald KM, Owens DK
Arch Pediatr Adolesc Med 2007 Sep;161(9):896-905. doi: 10.1001/archpedi.161.9.896. PMID: 17768291

Recent systematic reviews

Antitoxin Use in the Prevention and Treatment of Anthrax Disease: A Systematic Review.
Hesse EM, Godfred-Cato S, Bower WA
Clin Infect Dis 2022 Oct 17;75(Suppl 3):S432-S440. doi: 10.1093/cid/ciac532. PMID: 36251559Free PMC Article
Inhalational, gastrointestinal, and cutaneous anthrax in children: a systematic review of cases: 1900 to 2005.
Bravata DM, Holty JE, Wang E, Lewis R, Wise PH, McDonald KM, Owens DK
Arch Pediatr Adolesc Med 2007 Sep;161(9):896-905. doi: 10.1001/archpedi.161.9.896. PMID: 17768291
Anthrax: a systematic review of atypical presentations.
Holty JE, Kim RY, Bravata DM
Ann Emerg Med 2006 Aug;48(2):200-11. Epub 2006 Feb 21 doi: 10.1016/j.annemergmed.2005.11.035. PMID: 16857469

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