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Results: 20

1.

Leukopenia

an abnormally low white blood cell count [from CHV]

MedGen UID:
6073
Concept ID:
C0023530
Disease or Syndrome
2.

Leukopenia

A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen. [from NCI]

MedGen UID:
777040
Concept ID:
C0750394
Finding
3.

Error occurred: cannot get document summary

ID:
775793

4.

Leukopenia

An abnormal decreased number of leukocytes in the blood. [from HPO]

MedGen UID:
504985
Concept ID:
CN001702
Finding
5.

Chronic

A disease or condition that persists or progresses over a long period of time. [from NCI_NCI-GLOSS]

MedGen UID:
104657
Concept ID:
C0205191
6.

Source

Where something is available or from where it originates. [from NCI]

MedGen UID:
99076
Concept ID:
C0449416
Finding
7.

Thiopurine methyltransferase deficiency

The thiopurines include azathioprine (a pro-drug for mercaptopurine), mercaptopurine and thioguanine. They are used to treat a variety of immunological disorders such as rheumatoid arthritis, non- Hodgkin lymphoma and ulcerative colitis. Both mercaptopurine and thioguanine can exert cytotoxic effects through the formation of thioguanine nucleotides (TGNs), active metabolites that incorporate into DNA. Mercaptopurine and thioguanine are directly inactivated by thiopurine S-methyltransferase (TPMT). Individuals with two nonfunctional TPMT alleles are at 100% risk of potentially fatal myelosuppression, due to an increased buildup of toxic TGNs. Alternative agents or a drastically reduced dose are recommended for patients with this genotype. Patients heterozygous for a nonfunctional TPMT allele are at increased risk of myelosuppression, and reduced dosing is recommended for these individuals. These dosing guidelines have been published in Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and are available on the PharmGKB website (http://www.pharmgkb.org/gene/PA356) [from PharmGKB]

MedGen UID:
83352
Concept ID:
C0342801
Disease or Syndrome
8.

Disease Attributes

Clinical characteristics of disease or illness. [from MeSH]

MedGen UID:
199876
Concept ID:
C0752357
Disease or Syndrome
9.

Purinethol

A drug used to treat acute lymphatic leukemia. It belongs to the family of drugs called antimetabolites. [from NCI]

MedGen UID:
196307
Concept ID:
C0722911
Pharmacologic Substance
10.

Purimethol

MedGen UID:
182436
Concept ID:
C0917847
Pharmacologic Substance
11.

Leupurin

MedGen UID:
149060
Concept ID:
C0729100
Pharmacologic Substance
12.

Pathological Conditions, Signs and Symptoms

Abnormal anatomical or physiological conditions and objective or subjective manifestations of disease, not classified as disease or syndrome. [from MeSH]

MedGen UID:
21047
Concept ID:
C0039058
Sign or Symptom
13.

Pathologic Processes

The abnormal mechanisms and forms involved in the dysfunctions of tissues and organs. [from MeSH]

MedGen UID:
18325
Concept ID:
C0030660
Pathologic Function
14.

Mercaptopurine

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. [from MeSH]

MedGen UID:
7793
Concept ID:
C0000618
Pharmacologic Substance
15.

Inflammation

A microscopic finding indicating the presence of acute, subacute or chronic inflammation in a tissue sample. [from NCI]

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
16.

Chronic disease

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed) [from MeSH]

MedGen UID:
3453
Concept ID:
C0008679
Disease or Syndrome
17.

Mercaptopurina Wellcome

MedGen UID:
288851
Concept ID:
C1563962
Pharmacologic Substance
18.

Chronic disease absent

MedGen UID:
759750
Concept ID:
C3532637
Finding
19.

Deficiency of methyltransferase

MedGen UID:
713729
Concept ID:
C1291425
Disease or Syndrome
20.

No drug therapy prescribed

MedGen UID:
600035
Concept ID:
C0420222
Finding

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