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Tenofovir

MedGen UID:
94499
Concept ID:
C0384228
Pharmacologic Substance
Synonyms: 9-(2-phosphonomethoxypropyl)adenine; 9-(2-phosphonylmethoxypropyl)adenine; 9-PMPA; 9-PMPA (tenofovir); tenofovir
SNOMED CT: Tenofovir (395264002); 9(2-(phosphonomethoxy)propyl)adenine (395264002); PMPA (395264002); Tenofovir (422091007)
 

Definition

A nucleoside reverse transcriptase inhibitor analog of adenosine. [from NCI]

Recent clinical studies

Etiology

Baeten JM, Donnell D, Mugo NR, Ndase P, Thomas KK, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, Ronald A, Tumwesigye E, Were E, Fife KH, Kiarie J, Farquhar C, John-Stewart G, Kidoguchi L, Coombs RW, Hendrix C, Marzinke MA, Frenkel L, Haberer JE, Bangsberg D, Celum C; Partners PrEP Study Team
Lancet Infect Dis 2014 Nov;14(11):1055-64. Epub 2014 Oct 7 doi: 10.1016/S1473-3099(14)70937-5. [Epub ahead of print] PMID: 25300863Free PMC Article
Arribas JR, Pialoux G, Gathe J, Di Perri G, Reynes J, Tebas P, Nguyen T, Ebrahimi R, White K, Piontkowsky D
Lancet Infect Dis 2014 Jul;14(7):581-9. Epub 2014 Jun 5 doi: 10.1016/S1473-3099(14)70782-0. [Epub ahead of print] PMID: 24908551
Young J, Wang Q, Fux CA, Bernasconi E, Furrer H, Vernazza P, Calmy A, Cavassini M, Weber R, Battegay M, Bucher HC; Swiss HIV Cohort Study
HIV Med 2014 Sep;15(8):505-10. Epub 2014 Mar 18 doi: 10.1111/hiv.12149. [Epub ahead of print] PMID: 24641488
Brennan AT, Shearer K, Maskew M, Long L, Sanne I, Fox MP
Trop Med Int Health 2014 May;19(5):490-8. Epub 2014 Mar 3 doi: 10.1111/tmi.12285. [Epub ahead of print] PMID: 24589363
Bloch M, Tong WW, Hoy J, Baker D, Lee FJ, Richardson R, Carr A; TROP (Switch from Tenofovir to Raltegravir for Low Bone Density) study team
HIV Med 2014 Jul;15(6):373-80. Epub 2014 Jan 26 doi: 10.1111/hiv.12123. [Epub ahead of print] PMID: 24460797

Diagnosis

Celum C, Morrow RA, Donnell D, Hong T, Hendrix CW, Thomas KK, Fife KH, Nakku-Joloba E, Mujugira A, Baeten JM; Partners PrEP Study Team
Ann Intern Med 2014 Jul 1;161(1):11-9. doi: 10.7326/M13-2471. PMID: 24979446
Donnell D, Baeten JM, Bumpus NN, Brantley J, Bangsberg DR, Haberer JE, Mujugira A, Mugo N, Ndase P, Hendrix C, Celum C
J Acquir Immune Defic Syndr 2014 Jul 1;66(3):340-8. doi: 10.1097/QAI.0000000000000172. PMID: 24784763Free PMC Article
Krishna MM, Subbalaxmi MV, Uppin M, Radhika S
Indian J Pharmacol 2014 Mar-Apr;46(2):230-1. doi: 10.4103/0253-7613.129330. PMID: 24741201Free PMC Article
Wei X, Hunt G, Abdool Karim SS, Naranbhai V, Sibeko S, Abdool Karim Q, Li JF, Kashuba AD, Werner L, Passmore JA, Morris L, Heneine W, Johnson JA
J Infect Dis 2014 Jun 15;209(12):1916-20. Epub 2014 Jan 16 doi: 10.1093/infdis/jiu026. [Epub ahead of print] PMID: 24436453Free PMC Article
Paliwal N, Jain P, Dubey N, Sharma S, Khurana S, Kumar Paliwal S
Drug Res (Stuttg) 2014 Jun;64(6):306-12. Epub 2013 Dec 5 doi: 10.1055/s-0033-1361090. [Epub ahead of print] PMID: 24310362

Therapy

Kamkuemah M, Kaplan R, Bekker LG, Little F, Myer L
Trop Med Int Health 2015 Apr;20(4):518-26. Epub 2014 Dec 12 doi: 10.1111/tmi.12446. [Epub ahead of print] PMID: 25442109
Garrett NJ, Werner L, Naicker N, Naranbhai V, Sibeko S, Samsunder N, Gray C, Williamson C, Morris L, Abdool-Karim Q, Abdool-Karim SS
J Acquir Immune Defic Syndr 2015 Jan 1;68(1):55-61. doi: 10.1097/QAI.0000000000000367. PMID: 25247433Free PMC Article
Baeten JM, Donnell D, Mugo NR, Ndase P, Thomas KK, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, Ronald A, Tumwesigye E, Were E, Fife KH, Kiarie J, Farquhar C, John-Stewart G, Kidoguchi L, Coombs RW, Hendrix C, Marzinke MA, Frenkel L, Haberer JE, Bangsberg D, Celum C; Partners PrEP Study Team
Lancet Infect Dis 2014 Nov;14(11):1055-64. Epub 2014 Oct 7 doi: 10.1016/S1473-3099(14)70937-5. [Epub ahead of print] PMID: 25300863Free PMC Article
Young J, Wang Q, Fux CA, Bernasconi E, Furrer H, Vernazza P, Calmy A, Cavassini M, Weber R, Battegay M, Bucher HC; Swiss HIV Cohort Study
HIV Med 2014 Sep;15(8):505-10. Epub 2014 Mar 18 doi: 10.1111/hiv.12149. [Epub ahead of print] PMID: 24641488
Bloch M, Tong WW, Hoy J, Baker D, Lee FJ, Richardson R, Carr A; TROP (Switch from Tenofovir to Raltegravir for Low Bone Density) study team
HIV Med 2014 Jul;15(6):373-80. Epub 2014 Jan 26 doi: 10.1111/hiv.12123. [Epub ahead of print] PMID: 24460797

Prognosis

Kamkuemah M, Kaplan R, Bekker LG, Little F, Myer L
Trop Med Int Health 2015 Apr;20(4):518-26. Epub 2014 Dec 12 doi: 10.1111/tmi.12446. [Epub ahead of print] PMID: 25442109
Celum C, Morrow RA, Donnell D, Hong T, Hendrix CW, Thomas KK, Fife KH, Nakku-Joloba E, Mujugira A, Baeten JM; Partners PrEP Study Team
Ann Intern Med 2014 Jul 1;161(1):11-9. doi: 10.7326/M13-2471. PMID: 24979446
Scherzer R, Gandhi M, Estrella MM, Tien PC, Deeks SG, Grunfeld C, Peralta CA, Shlipak MG
AIDS 2014 Jun 1;28(9):1289-95. doi: 10.1097/QAD.0000000000000258. PMID: 24922479Free PMC Article
Brennan AT, Shearer K, Maskew M, Long L, Sanne I, Fox MP
Trop Med Int Health 2014 May;19(5):490-8. Epub 2014 Mar 3 doi: 10.1111/tmi.12285. [Epub ahead of print] PMID: 24589363
Landman R, Koulla-Shiro S, Sow PS, Ngolle M, Diallo MB, Guèye NF, Le Moing V, Eymard-Duvernay S, Benalycherif A, Charpentier C, Peytavin G, Delaporte E, Girard PM; DAYANA Study Group
Antivir Ther 2014;19(1):51-9. Epub 2013 Aug 23 doi: 10.3851/IMP2675. [Epub ahead of print] PMID: 23970206

Clinical prediction guides

Kamkuemah M, Kaplan R, Bekker LG, Little F, Myer L
Trop Med Int Health 2015 Apr;20(4):518-26. Epub 2014 Dec 12 doi: 10.1111/tmi.12446. [Epub ahead of print] PMID: 25442109
Scherzer R, Gandhi M, Estrella MM, Tien PC, Deeks SG, Grunfeld C, Peralta CA, Shlipak MG
AIDS 2014 Jun 1;28(9):1289-95. doi: 10.1097/QAD.0000000000000258. PMID: 24922479Free PMC Article
Markowitz M, Zolopa A, Squires K, Ruane P, Coakley D, Kearney B, Zhong L, Wulfsohn M, Miller MD, Lee WA
J Antimicrob Chemother 2014 May;69(5):1362-9. Epub 2014 Feb 6 doi: 10.1093/jac/dkt532. [Epub ahead of print] PMID: 24508897
Bloch M, Tong WW, Hoy J, Baker D, Lee FJ, Richardson R, Carr A; TROP (Switch from Tenofovir to Raltegravir for Low Bone Density) study team
HIV Med 2014 Jul;15(6):373-80. Epub 2014 Jan 26 doi: 10.1111/hiv.12123. [Epub ahead of print] PMID: 24460797
Herold BC, Dezzutti CS, Richardson BA, Marrazzo J, Mesquita PM, Carpenter C, Huber A, Louissaint N, Marzinke MA, Hillier SL, Hendrix CW
J Acquir Immune Defic Syndr 2014 May 1;66(1):65-73. doi: 10.1097/QAI.0000000000000110. PMID: 24457633Free PMC Article

Recent systematic reviews

Winston J, Chonchol M, Gallant J, Durr J, Canada RB, Liu H, Martin P, Patel K, Hindman J, Piontkowsky D
HIV Clin Trials 2014 Nov-Dec;15(6):231-45. doi: 10.1310/hct1506-231. PMID: 25433663
Jafari A, Khalili H, Dashti-Khavidaki S
Eur J Clin Pharmacol 2014 Sep;70(9):1029-40. Epub 2014 Jun 25 doi: 10.1007/s00228-014-1712-z. [Epub ahead of print] PMID: 24958564
Ke W, Liu L, Zhang C, Ye X, Gao Y, Zhou S, Yang Y
PLoS One 2014;9(6):e98865. Epub 2014 Jun 6 doi: 10.1371/journal.pone.0098865. PMID: 24905092Free PMC Article
Wang L, Kourtis AP, Ellington S, Legardy-Williams J, Bulterys M
Clin Infect Dis 2013 Dec;57(12):1773-81. Epub 2013 Sep 17 doi: 10.1093/cid/cit601. [Epub ahead of print] PMID: 24046310
Price H, Dunn D, Pillay D, Bani-Sadr F, de Vries-Sluijs T, Jain MK, Kuzushita N, Mauss S, Núñez M, Nüesch R, Peters M, Reiberger T, Stephan C, Tan L, Gilson R
PLoS One 2013;8(7):e68152. Epub 2013 Jul 10 doi: 10.1371/journal.pone.0068152. PMID: 23874527Free PMC Article

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