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Results: 4

1.

Atazanavir

A synthetic antiviral agent. As a symmetric azapeptide agent structurally different from other HIV protease inhibitors, atazanavir selectively binds to and inhibits human immunodeficiency virus (HIV) protease, thereby preventing cleavage of the gag-pol viral polyprotein and resulting in the release of immature, noninfectious virions. This agent does not elevate serum lipids, a common problem with other protease inhibitors. (NCI04) [from NCI]

MedGen UID:
218840
Concept ID:
C1145759
Pharmacologic Substance
2.

An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. [from MeSH]

MedGen UID:
132886
Concept ID:
C0292818
3.

Tenofovir disoproxil fumarate

A pro-drug, a fumaric acid salt of tenofovir and an acyclic nucleoside phosphonate diester analog with antiviral property. In vivo tenofovir disoproxil fumarate is converted into tenofovir by diester hydrolysis in the intestinal lumen and plasma, followed by internalization into cells by endocytosis and subsequent phosphorylation into tenofovir diphosphate. Tenofovir diphosphate competes with the natural substrate dATP for incorporation into viral DNA by reverse transcriptase of human immunodeficiency virus (HIV). The substituted DNA-tenofovir diphosphate molecule prevents further DNA elongation, and consequently impairs viral replication and propagation. This agent prevents HIV from reproducing in uninfected cells only. Tenofovir also exhibits activity against the hepatitis B virus (HBV). [from NCI]

MedGen UID:
204740
Concept ID:
C1099776
Pharmacologic Substance
4.

MedGen UID:
192561
Concept ID:
C0963398

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