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Results: 9

1.

Gastroesophageal reflux disease

Gastroesophageal reflux (GER) is characterized by the retrograde movement of stomach contents into the esophagus. In its most severe form, GER results in extensive tissue damage caused by acid reflux. In adolescents and adults, and even infrequently in children, chronic GER is associated with the risk of developing Barrett metaplasia (614266), a premalignant lesion of the esophageal mucosa (Hu et al., 2000). In turn, Barrett metaplasia is correlated with the development of adenocarcinoma of the esophagus (see 614266), estimated as the fifth most prevalent neoplasia in the Western world (Lagergren et al., 1999). [from OMIM]

MedGen UID:
6553
Concept ID:
C0017168
Disease or Syndrome
2.

Disease

Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. [from NCI]

MedGen UID:
4347
Concept ID:
C0012634
Disease or Syndrome
3.

disease

MedGen UID:
798428
Concept ID:
CN204926
Disease or Syndrome
4.

Gastroesophageal reflux

A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter. [from HPO]

MedGen UID:
505057
Concept ID:
CN001828
Finding
5.

Limonene, (+/-)-

A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes. [from NCI]

MedGen UID:
406483
Concept ID:
C1880232
Pharmacologic Substance
6.

Limonene, (+)-

A terpene with two isoprene units forming a ring. The chemical structure is CC1=CCC(CC1)C(=C)C. [from NCI]

MedGen UID:
183800
Concept ID:
C0950252
Pharmacologic Substance
7.

Reflux

The term used when liquid backs up into the esophagus from the stomach. [from NCI]

MedGen UID:
66675
Concept ID:
C0232483
Pathologic Function
8.

Drugs, Non-Prescription

Medicines that can be sold legally without a DRUG PRESCRIPTION. [from MeSH]

MedGen UID:
4409
Concept ID:
C0013231
Pharmacologic Substance
9.

Esophageal stricture

A pathological narrowing of the esophagus that is caused by the development of a ring of scar tissue that constricts the esophageal lumen. [from HPO]

MedGen UID:
505068
Concept ID:
CN001847
Finding

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