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Tocolytic drug

MedGen UID:
11836
Concept ID:
C0040349
Pharmacologic Substance
Synonyms: Agents, Tocolytic; Tocolytic Agents; Tocolytics
SNOMED CT: Tocolytic drug (262212007)
 

Definition

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGTocolytic drug

Recent clinical studies

Etiology

Urquhart C, Currell R, Harlow F, Callow L
Cochrane Database Syst Rev 2012 May 16;5:CD006172. doi: 10.1002/14651858.CD006172.pub2. PMID: 22592709
Fabry I, De Paepe P, Kips J, Vermeersch S, Van Bortel L
Eur J Clin Pharmacol 2011 Jan;67(1):11-7. Epub 2010 Nov 16 doi: 10.1007/s00228-010-0926-y. [Epub ahead of print] PMID: 21079937
Luewan S, Mahathep R, Tongsong T
Arch Gynecol Obstet 2011 Sep;284(3):527-30. Epub 2010 Sep 16 doi: 10.1007/s00404-010-1674-z. [Epub ahead of print] PMID: 20844887
Lin CH, Lin SY, Shyu MK, Chen SU, Lee CN
J Formos Med Assoc 2009 Jun;108(6):493-501. doi: 10.1016/S0929-6646(09)60097-8. PMID: 19515630
Miller DD
J Intraven Nurs 1995 Sep-Oct;18(5):223-8. PMID: 7562221

Diagnosis

Urquhart C, Currell R, Harlow F, Callow L
Cochrane Database Syst Rev 2012 May 16;5:CD006172. doi: 10.1002/14651858.CD006172.pub2. PMID: 22592709
Helmer H, Brunbauer M, Rohrmeister K
BJOG 2003 Apr;110 Suppl 20:113-5. PMID: 12763126
Leszczynska-Gorzelak B, Laskowska M, Marciniak B, Oleszczuk J
Int J Gynaecol Obstet 2001 Jun;73(3):201-6. PMID: 11376665
Mueller L
J Obstet Gynecol Neonatal Nurs 1991 Jul-Aug;20(4):284-9. PMID: 1941290
Rayburn WF, Fontana ME
Am J Obstet Gynecol 1981 Sep 1;141(1):9-11. PMID: 7270625

Therapy

Urquhart C, Currell R, Harlow F, Callow L
Cochrane Database Syst Rev 2012 May 16;5:CD006172. doi: 10.1002/14651858.CD006172.pub2. PMID: 22592709
Fabry I, De Paepe P, Kips J, Vermeersch S, Van Bortel L
Eur J Clin Pharmacol 2011 Jan;67(1):11-7. Epub 2010 Nov 16 doi: 10.1007/s00228-010-0926-y. [Epub ahead of print] PMID: 21079937
Luewan S, Mahathep R, Tongsong T
Arch Gynecol Obstet 2011 Sep;284(3):527-30. Epub 2010 Sep 16 doi: 10.1007/s00404-010-1674-z. [Epub ahead of print] PMID: 20844887
Lin CH, Lin SY, Shyu MK, Chen SU, Lee CN
J Formos Med Assoc 2009 Jun;108(6):493-501. doi: 10.1016/S0929-6646(09)60097-8. PMID: 19515630
Keirse MJ
Br J Obstet Gynaecol 1984 May;91(5):424-30. PMID: 6144322

Prognosis

Urquhart C, Currell R, Harlow F, Callow L
Cochrane Database Syst Rev 2012 May 16;5:CD006172. doi: 10.1002/14651858.CD006172.pub2. PMID: 22592709
Van De Water M, Kessel ET, De Kleine MJ, Oei SG
Acta Obstet Gynecol Scand 2008;87(3):340-5. doi: 10.1080/00016340801913189. PMID: 18307075
Doyle NM, Gardner MO, Wells L, Qualls C, Papile LA
J Perinatol 2005 May;25(5):336-40. doi: 10.1038/sj.jp.7211256. PMID: 15861198
Leszczynska-Gorzelak B, Laskowska M, Marciniak B, Oleszczuk J
Int J Gynaecol Obstet 2001 Jun;73(3):201-6. PMID: 11376665
Catanzarite VA, Willms DC, Holdy KE, Gardner SE, Ludwig DM, Cousins LM
Am J Perinatol 1997 Aug;14(7):431-4. doi: 10.1055/s-2007-994175. PMID: 9263566

Clinical prediction guides

Van De Water M, Kessel ET, De Kleine MJ, Oei SG
Acta Obstet Gynecol Scand 2008;87(3):340-5. doi: 10.1080/00016340801913189. PMID: 18307075
Weintraub Z, Solovechick M, Reichman B, Rotschild A, Waisman D, Davkin O, Lusky A, Bental Y; Israel Neonatal Network
Arch Dis Child Fetal Neonatal Ed 2001 Jul;85(1):F13-7. PMID: 11420315Free PMC Article
Leszczynska-Gorzelak B, Laskowska M, Marciniak B, Oleszczuk J
Int J Gynaecol Obstet 2001 Jun;73(3):201-6. PMID: 11376665
Knock GA, Aaronson PI
Br J Pharmacol 1999 Jul;127(6):1470-8. doi: 10.1038/sj.bjp.0702685. PMID: 10455298Free PMC Article
Aarimaa T, Ekblad U, Erkkola R, Kanto J, Kero P
Gynecol Obstet Invest 1987;23(3):160-6. PMID: 3110023

Recent systematic reviews

Urquhart C, Currell R, Harlow F, Callow L
Cochrane Database Syst Rev 2012 May 16;5:CD006172. doi: 10.1002/14651858.CD006172.pub2. PMID: 22592709

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