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Results: 7

1.

A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic domain of the histone deacetylases (HDACs). This allows the hydroxamic moiety to chelate zinc ion located in the catalytic pockets of HDAC, thereby inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Hyperacetylation of histone proteins results in the upregulation of the cyclin-dependant kinase p21, followed by G1 arrest. Hyperacetylation of non-histone proteins such as tumor suppressor p53, alpha tubulin, and heat-shock protein 90 produces additional anti-proliferative effects. This agent also induces apoptosis and sensitizes tumor cells to cell death processes. Vorinostat crosses the blood-brain barrier. [from NCI]

MedGen UID:
151315
Concept ID:
C0672708
2.

Tamoxifen

syntactic hormone used in breast cancer treatment [from CHV]

MedGen UID:
52642
Concept ID:
C0039286
Pharmacologic Substance
3.

Malignant tumor of breast

A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males. [from NCI]

MedGen UID:
651
Concept ID:
C0006142
Neoplastic Process
4.

Tamoxifen

MedGen UID:
450034
Concept ID:
CN077559
Pharmacologic Substance
5.

Breast carcinoma

The presence of a `carcinoma` (MPATH:549) of the `breast` (FMA:9601). [from HPO]

MedGen UID:
428324
Concept ID:
CN002714
Finding
6.

Histone deacetylase inhibitor

A substance that causes a chemical change that stops tumor cells from dividing. HDAC inhibitors are being studied in the treatment of cancer. [from NCI]

MedGen UID:
268200
Concept ID:
C1512474
Pharmacologic Substance
7.

Neoplasm of breast

Tumors or cancer of the human BREAST. [from MeSH]

MedGen UID:
264172
Concept ID:
C1458155
Neoplastic Process

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