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Results: 9

1.

Eribulin mesylate

The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. [from NCI]

MedGen UID:
435853
Concept ID:
C2608038
Pharmacologic Substance
2.

eribulin

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitubulin agents. [from NCI]

MedGen UID:
379310
Concept ID:
C2350866
Pharmacologic Substance
3.

Malignant tumor of breast

A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males. [from NCI]

MedGen UID:
651
Concept ID:
C0006142
Neoplastic Process
4.

Breast carcinoma

The presence of a `carcinoma` (MPATH:549) of the `breast` (FMA:9601). [from HPO]

MedGen UID:
428324
Concept ID:
CN002714
Finding
5.

Tubulin Modulators

Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. [from MeSH]

MedGen UID:
288802
Concept ID:
C1563757
Pharmacologic Substance
6.

Neoplasm of breast

Tumors or cancer of the human BREAST. [from MeSH]

MedGen UID:
264172
Concept ID:
C1458155
Neoplastic Process
7.

larotaxel

A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier. [from NCI]

MedGen UID:
380627
Concept ID:
C2603883
Pharmacologic Substance
8.

A bi-fluorinated derivative of the semi-synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis. Compared to other vinca alkaloids, this agent binds weakly to the vinca-binding site, indicating that vinflunine may exhibit reduced neurotoxicity. [from NCI]

MedGen UID:
145717
Concept ID:
C0672663
9.

halichondrin B

A complex macrolide polyether from marine sponge genera, such as Halichondria, Axinella, Phakellia, and Lissodendoryx that binds to tubulin, thereby inhibiting mitosis. (NCI) [from NCI]

MedGen UID:
92590
Concept ID:
C0120715
Pharmacologic Substance

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