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Maalox

MedGen UID:
32424
Concept ID:
C0065461
Pharmacologic Substance
 

Definition

An oral suspension with antacid effects. Maalox, a combination of aluminum hydroxide and magnesium hydroxide, neutralizes or reduces gastric acid, thereby relieving symptoms associated with indigestion, gastritis, and gastroesophageal disease (GERD). Combined with other liquid ingredients (such as lidocaine and diphenhydramine), this antacid provides relief for painful stomatitis, mucositis, and esophagitis associated with both chemotherapy and radiation therapy. Maalox is also available as a chewable tablet containing calcium carbonate. [from NCI]

Recent clinical studies

Etiology

Tighe M, Afzal NA, Bevan A, Hayen A, Munro A, Beattie RM
Cochrane Database Syst Rev 2014 Nov 24;11:CD008550. doi: 10.1002/14651858.CD008550.pub2. PMID: 25419906
Wilner KD, Hansen RA, Folger CJ, Geoffroy P
Br J Clin Pharmacol 2000;49 Suppl 1:57S-60S. PMID: 10771455Free PMC Article
Faaij RA, Van Gerven JM, Jolivet-Landreau I, Masclee AA, Vendrig EM, Schoemaker RC, Jacobs LD, Cohen AF
Aliment Pharmacol Ther 1999 Dec;13(12):1605-10. PMID: 10594395
Johnston DA, Marks IN, Young GO, Tigler-Wybrandi NA, Bridger S, Zak J
Am J Med 1991 Aug 8;91(2A):91S-94S. PMID: 1882910
Bardhan KD, Hunter JO, Miller JP, Thomson AB, Graham DY, Russell RI, Sontag S, Hines C, Martin T, Gaussen L
Gut 1988 Dec;29(12):1748-54. PMID: 3065157Free PMC Article

Diagnosis

Faden H
Pediatr Emerg Care 2006 Apr;22(4):268-9. doi: 10.1097/01.pec.0000218982.46225.f5. PMID: 16651921
Fujishiro M, Ono H, Gotoda T, Yamaguchi H, Kondo H, Saito D
Endoscopy 2001 Feb;33(2):196. PMID: 11272228
Moghadam BK, Gier R, Thurlow T
Cutis 1999 Aug;64(2):131-4. PMID: 10467509
Ernst O, Sergent G, L'Hermine C
J Magn Reson Imaging 1997 May-Jun;7(3):495-8. PMID: 9170033
Johnston DA, Marks IN, Young GO, Tigler-Wybrandi NA, Bridger S, Zak J
Am J Med 1991 Aug 8;91(2A):91S-94S. PMID: 1882910

Therapy

Faaij RA, Van Gerven JM, Jolivet-Landreau I, Masclee AA, Vendrig EM, Schoemaker RC, Jacobs LD, Cohen AF
Aliment Pharmacol Ther 1999 Dec;13(12):1605-10. PMID: 10594395
Allen A, Vousden M, Porter A, Lewis A
Chemotherapy 1999 Nov-Dec;45(6):504-11. PMID: 10567782
Reigner B, Clive S, Cassidy J, Jodrell D, Schulz R, Goggin T, Banken L, Roos B, Utoh M, Mulligan T, Weidekamm E
Cancer Chemother Pharmacol 1999;43(4):309-15. doi: 10.1007/s002800050900. PMID: 10071982
Johnson RD, Dorr MB, Talbot GH, Caille G
Clin Ther 1998 Nov-Dec;20(6):1149-58. PMID: 9916608
Hürlimann S, Michel K, Inauen W, Halter F
Am J Gastroenterol 1996 Jun;91(6):1173-80. PMID: 8651166

Prognosis

Tighe M, Afzal NA, Bevan A, Hayen A, Munro A, Beattie RM
Cochrane Database Syst Rev 2014 Nov 24;11:CD008550. doi: 10.1002/14651858.CD008550.pub2. PMID: 25419906
Barry JD, Hennessy R, McManus JG Jr
Prehosp Emerg Care 2008 Oct-Dec;12(4):432-7. doi: 10.1080/10903120802290786. PMID: 18924005
Chandra R, Liu P, Breen JD, Fisher J, Xie C, LaBadie R, Benner RJ, Benincosa LJ, Sharma A
Clin Pharmacokinet 2007;46(3):247-59. doi: 10.2165/00003088-200746030-00005. PMID: 17328583
Miyata K, Ohtani H, Tsujimoto M, Sawada Y
Int J Clin Pharmacol Ther 2007 Jan;45(1):63-70. PMID: 17256452
Faden H
Pediatr Emerg Care 2006 Apr;22(4):268-9. doi: 10.1097/01.pec.0000218982.46225.f5. PMID: 16651921

Clinical prediction guides

Faaij RA, Van Gerven JM, Jolivet-Landreau I, Masclee AA, Vendrig EM, Schoemaker RC, Jacobs LD, Cohen AF
Aliment Pharmacol Ther 1999 Dec;13(12):1605-10. PMID: 10594395
Reigner B, Clive S, Cassidy J, Jodrell D, Schulz R, Goggin T, Banken L, Roos B, Utoh M, Mulligan T, Weidekamm E
Cancer Chemother Pharmacol 1999;43(4):309-15. doi: 10.1007/s002800050900. PMID: 10071982
Mück W, Ritter W, Dietrich H, Frey R, Kuhlmann J
Int J Clin Pharmacol Ther 1997 Jun;35(6):261-4. PMID: 9208343
Hürlimann S, Michel K, Inauen W, Halter F
Am J Gastroenterol 1996 Jun;91(6):1173-80. PMID: 8651166
Florent C, Desaint B, Legendre C, Chappuis P, Galle C, Giboudeau J, de Meynard C
J Clin Gastroenterol 1991;13 Suppl 1:S139-44. PMID: 1940188

Recent systematic reviews

Tighe M, Afzal NA, Bevan A, Hayen A, Munro A, Beattie RM
Cochrane Database Syst Rev 2014 Nov 24;11:CD008550. doi: 10.1002/14651858.CD008550.pub2. PMID: 25419906
Sewing KF
J Clin Gastroenterol 1991;13 Suppl 1:S134-8. PMID: 1834730

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