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Parkinson disease(PD)

MedGen UID:
10590
Concept ID:
C0030567
Disease or Syndrome
Synonyms: PD
SNOMED CT: Idiopathic Parkinson's disease (49049000); Parkinson disease (49049000); PD - Parkinson's disease (49049000); Parkinsons disease (49049000); Primary Parkinsonism (49049000); Idiopathic Parkinsonism (49049000); Parkinson's disease (49049000); Paralysis agitans (49049000); Idiopathic parkinsonism (49049000); Primary parkinsonism (49049000); Shaking palsy (49049000)
 
OMIM®: 168600; 516000

Disease characteristics

Excerpted from the GeneReview: Parkinson Disease Overview
Parkinsonism refers to all clinical states characterized by tremor, muscle rigidity, slowed movement (bradykinesia) and often postural instability. Parkinson disease is the primary and most common form of parkinsonism. Psychiatric manifestations, which include depression and visual hallucinations, are common but not uniformly present. Dementia eventually occurs in at least 20% of cases. The most common sporadic form of Parkinson disease manifests around age 60; however, young-onset and even juvenile presentations are seen. [from GeneReviews]
Full text of GeneReview (by section):
Summary  |  Definition  |  Causes  |  Evaluation Strategy  |  Genetic Counseling  |  Resources  |  Management  |  References  |  Chapter Notes
Authors:
Janice Farlow  |  Nathan D Pankratz  |  Joanne Wojcieszek, et. al.   view full author information

Term Hierarchy

Recent clinical studies

Etiology

Liu FC, Huang WY, Lin TY, Shen CH, Chou YC, Lin CL, Lin KT, Kao CH
Medicine (Baltimore) 2015 Nov;94(46):e2097. doi: 10.1097/MD.0000000000002097. PMID: 26579824Free PMC Article
Connolly JG, Bykov K, Gagne JJ
Am J Epidemiol 2015 Dec 1;182(11):936-44. Epub 2015 Oct 22 doi: 10.1093/aje/kwv109. [Epub ahead of print] PMID: 26493264Free PMC Article
Schroeder JE, Hughes A, Sama A, Weinstein J, Kaplan L, Cammisa FP, Girardi FP
J Bone Joint Surg Am 2015 Oct 21;97(20):1661-6. doi: 10.2106/JBJS.N.01049. PMID: 26491130
Joutsa J, Johansson J, Seppänen M, Noponen T, Kaasinen V
J Nucl Med 2015 Jul;56(7):1036-41. Epub 2015 May 7 doi: 10.2967/jnumed.115.153734. [Epub ahead of print] PMID: 25952735
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS, Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills AM
JAMA 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120. PMID: 25668262Free PMC Article

Diagnosis

Liu FC, Huang WY, Lin TY, Shen CH, Chou YC, Lin CL, Lin KT, Kao CH
Medicine (Baltimore) 2015 Nov;94(46):e2097. doi: 10.1097/MD.0000000000002097. PMID: 26579824Free PMC Article
Connolly JG, Bykov K, Gagne JJ
Am J Epidemiol 2015 Dec 1;182(11):936-44. Epub 2015 Oct 22 doi: 10.1093/aje/kwv109. [Epub ahead of print] PMID: 26493264Free PMC Article
Murakami Y, Kakeda S, Watanabe K, Ueda I, Ogasawara A, Moriya J, Ide S, Futatsuya K, Sato T, Okada K, Uozumi T, Tsuji S, Liu T, Wang Y, Korogi Y
AJNR Am J Neuroradiol 2015 Jun;36(6):1102-8. Epub 2015 Mar 12 doi: 10.3174/ajnr.A4260. [Epub ahead of print] PMID: 25767187
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS, Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills AM
JAMA 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120. PMID: 25668262Free PMC Article
Cosottini M, Frosini D, Pesaresi I, Donatelli G, Cecchi P, Costagli M, Biagi L, Ceravolo R, Bonuccelli U, Tosetti M
AJNR Am J Neuroradiol 2015 Mar;36(3):461-6. Epub 2014 Nov 6 doi: 10.3174/ajnr.A4158. [Epub ahead of print] PMID: 25376811

Therapy

Liu FC, Huang WY, Lin TY, Shen CH, Chou YC, Lin CL, Lin KT, Kao CH
Medicine (Baltimore) 2015 Nov;94(46):e2097. doi: 10.1097/MD.0000000000002097. PMID: 26579824Free PMC Article
Connolly JG, Bykov K, Gagne JJ
Am J Epidemiol 2015 Dec 1;182(11):936-44. Epub 2015 Oct 22 doi: 10.1093/aje/kwv109. [Epub ahead of print] PMID: 26493264Free PMC Article
Johnson KE
Prim Care 2015 Jun;42(2):205-15. Epub 2015 Mar 5 doi: 10.1016/j.pop.2015.01.005. [Epub ahead of print] PMID: 25979582
Mahler LA, Ramig LO, Fox C
Curr Opin Otolaryngol Head Neck Surg 2015 Jun;23(3):209-15. doi: 10.1097/MOO.0000000000000151. PMID: 25943966
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS, Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills AM
JAMA 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120. PMID: 25668262Free PMC Article

Prognosis

Liu FC, Huang WY, Lin TY, Shen CH, Chou YC, Lin CL, Lin KT, Kao CH
Medicine (Baltimore) 2015 Nov;94(46):e2097. doi: 10.1097/MD.0000000000002097. PMID: 26579824Free PMC Article
Johnson KE
Prim Care 2015 Jun;42(2):205-15. Epub 2015 Mar 5 doi: 10.1016/j.pop.2015.01.005. [Epub ahead of print] PMID: 25979582
Joutsa J, Johansson J, Seppänen M, Noponen T, Kaasinen V
J Nucl Med 2015 Jul;56(7):1036-41. Epub 2015 May 7 doi: 10.2967/jnumed.115.153734. [Epub ahead of print] PMID: 25952735
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS, Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills AM
JAMA 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120. PMID: 25668262Free PMC Article
Kotagal V, Albin RL, Müller ML, Koeppe RA, Studenski S, Frey KA, Bohnen NI
J Gerontol A Biol Sci Med Sci 2014 Dec;69(12):1569-75. Epub 2014 May 26 doi: 10.1093/gerona/glu070. [Epub ahead of print] PMID: 24864306Free PMC Article

Clinical prediction guides

Liu FC, Huang WY, Lin TY, Shen CH, Chou YC, Lin CL, Lin KT, Kao CH
Medicine (Baltimore) 2015 Nov;94(46):e2097. doi: 10.1097/MD.0000000000002097. PMID: 26579824Free PMC Article
Connolly JG, Bykov K, Gagne JJ
Am J Epidemiol 2015 Dec 1;182(11):936-44. Epub 2015 Oct 22 doi: 10.1093/aje/kwv109. [Epub ahead of print] PMID: 26493264Free PMC Article
Schroeder JE, Hughes A, Sama A, Weinstein J, Kaplan L, Cammisa FP, Girardi FP
J Bone Joint Surg Am 2015 Oct 21;97(20):1661-6. doi: 10.2106/JBJS.N.01049. PMID: 26491130
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS, Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills AM
JAMA 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120. PMID: 25668262Free PMC Article
Cosottini M, Frosini D, Pesaresi I, Donatelli G, Cecchi P, Costagli M, Biagi L, Ceravolo R, Bonuccelli U, Tosetti M
AJNR Am J Neuroradiol 2015 Mar;36(3):461-6. Epub 2014 Nov 6 doi: 10.3174/ajnr.A4158. [Epub ahead of print] PMID: 25376811

Recent systematic reviews

Leung IH, Walton CC, Hallock H, Lewis SJ, Valenzuela M, Lampit A
Neurology 2015 Nov 24;85(21):1843-51. Epub 2015 Oct 30 doi: 10.1212/WNL.0000000000002145. [Epub ahead of print] PMID: 26519540Free PMC Article
Lertxundi U, Ruiz AI, Aspiazu MÁ, Domingo-Echaburu S, García M, Aguirre C, García-Moncó JC
Clin Neuropharmacol 2015 May-Jun;38(3):69-84. doi: 10.1097/WNF.0000000000000080. PMID: 25970275
Mahler LA, Ramig LO, Fox C
Curr Opin Otolaryngol Head Neck Surg 2015 Jun;23(3):209-15. doi: 10.1097/MOO.0000000000000151. PMID: 25943966
Cruickshank TM, Reyes AR, Ziman MR
Medicine (Baltimore) 2015 Jan;94(4):e411. doi: 10.1097/MD.0000000000000411. PMID: 25634170Free PMC Article
Liu Y, Li W, Tan C, Liu X, Wang X, Gui Y, Qin L, Deng F, Hu C, Chen L
J Neurosurg 2014 Sep;121(3):709-18. Epub 2014 Jun 6 doi: 10.3171/2014.4.JNS131711. [Epub ahead of print] PMID: 24905564

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