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Fetal alcohol syndrome

MedGen UID:
8820
Concept ID:
C0015923
Disease or Syndrome
Synonyms: Fetal Alcohol Syndrome; Fetal Alcohol Syndromes; Syndrome, Fetal Alcohol
SNOMED CT: Foetal alcohol syndrome (205788004); FAS - Foetal alcohol syndrome (205788004); Fetal alcohol syndrome (205788004); FAS - Fetal alcohol syndrome (205788004)
 
Orphanet: ORPHA1915

Definition

Alcohol can harm your baby at any stage during a pregnancy. That includes the earliest stages before you even know you are pregnant. Drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (FASDs). Effects can include physical and behavioral problems such as trouble with. -Learning and remembering. -Understanding and following directions. -Controlling emotions. -Communicating and socializing. -Daily life skills, such as feeding and bathing. Fetal alcohol syndrome is the most serious type of FASD. People with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. FASDs last a lifetime. There is no cure for FASDs. Treatments can help. These include medicines to help with some symptoms and behavior therapy. No one treatment is right for every child. Centers for Disease Control and Prevention.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal alcohol syndrome
Follow this link to review classifications for Fetal alcohol syndrome in Orphanet.

Recent clinical studies

Etiology

O'Leary LA, Ortiz L, Montgomery A, Fox DJ, Cunniff C, Ruttenber M, Breen A, Pettygrove S, Klumb D, Druschel C, Frías JL, Robinson LK, Bertrand J, Ferrara K, Kelly M, Gilboa SM, Meaney FJ; FASSNetII
Birth Defects Res A Clin Mol Teratol 2015 Mar;103(3):196-202. Epub 2015 Mar 12 doi: 10.1002/bdra.23335. [Epub ahead of print] PMID: 25761572Free PMC Article
Rangmar J, Sandberg AD, Aronson M, Fahlke C
Nord J Psychiatry 2015 Aug;69(6):472-8. Epub 2015 Feb 20 doi: 10.3109/08039488.2015.1009487. [Epub ahead of print] PMID: 25697067
Rangmar J, Hjern A, Vinnerljung B, Strömland K, Aronson M, Fahlke C
Pediatrics 2015 Jan;135(1):e52-8. Epub 2014 Dec 22 doi: 10.1542/peds.2014-1915. [Epub ahead of print] PMID: 25535260
Moberg DP, Bowser J, Burd L, Elliott AJ, Punyko J, Wilton G; Fetal Alcohol Syndrome Surveillance Program-FASSLink Team
Birth Defects Res A Clin Mol Teratol 2014 Sep;100(9):663-9. Epub 2014 Apr 16 doi: 10.1002/bdra.23245. [Epub ahead of print] PMID: 24737611Free PMC Article
Hansen C, Adams M, Fox DJ, O'Leary LA, Frías JL, Freiman H, Meaney FJ
Birth Defects Res A Clin Mol Teratol 2014 Feb;100(2):67-78. Epub 2014 Feb 12 doi: 10.1002/bdra.23207. [Epub ahead of print] PMID: 24591358Free PMC Article

Diagnosis

Rangmar J, Sandberg AD, Aronson M, Fahlke C
Nord J Psychiatry 2015 Aug;69(6):472-8. Epub 2015 Feb 20 doi: 10.3109/08039488.2015.1009487. [Epub ahead of print] PMID: 25697067
Fox DJ, Pettygrove S, Cunniff C, O'Leary LA, Gilboa SM, Bertrand J, Druschel CM, Breen A, Robinson L, Ortiz L, Frías JL, Ruttenber M, Klumb D, Meaney FJ; Centers for Disease Control and Prevention (CDC)
MMWR Morb Mortal Wkly Rep 2015 Jan 30;64(3):54-7. PMID: 25632951
Rangmar J, Hjern A, Vinnerljung B, Strömland K, Aronson M, Fahlke C
Pediatrics 2015 Jan;135(1):e52-8. Epub 2014 Dec 22 doi: 10.1542/peds.2014-1915. [Epub ahead of print] PMID: 25535260
Moberg DP, Bowser J, Burd L, Elliott AJ, Punyko J, Wilton G; Fetal Alcohol Syndrome Surveillance Program-FASSLink Team
Birth Defects Res A Clin Mol Teratol 2014 Sep;100(9):663-9. Epub 2014 Apr 16 doi: 10.1002/bdra.23245. [Epub ahead of print] PMID: 24737611Free PMC Article
Hansen C, Adams M, Fox DJ, O'Leary LA, Frías JL, Freiman H, Meaney FJ
Birth Defects Res A Clin Mol Teratol 2014 Feb;100(2):67-78. Epub 2014 Feb 12 doi: 10.1002/bdra.23207. [Epub ahead of print] PMID: 24591358Free PMC Article

Therapy

Joya X, Garcia-Algar O, Salat-Batlle J, Pujades C, Vall O
Birth Defects Res A Clin Mol Teratol 2015 Mar;103(3):163-77. Epub 2014 Aug 18 doi: 10.1002/bdra.23290. [Epub ahead of print] PMID: 25131946
Smith SM, Garic A, Flentke GR, Berres ME
Birth Defects Res C Embryo Today 2014 Sep;102(3):210-20. Epub 2014 Sep 15 doi: 10.1002/bdrc.21078. [Epub ahead of print] PMID: 25219761
Larcher V, Brierley J
Arch Dis Child 2014 Nov;99(11):969-70. Epub 2014 Jul 8 doi: 10.1136/archdischild-2014-306774. [Epub ahead of print] PMID: 25005521Free PMC Article
Feltes BC, de Faria Poloni J, Nunes IJ, Bonatto D
OMICS 2014 Jun;18(6):344-63. Epub 2014 May 9 doi: 10.1089/omi.2013.0144. [Epub ahead of print] PMID: 24816220Free PMC Article
May PA, Tabachnick BG, Gossage JP, Kalberg WO, Marais AS, Robinson LK, Manning M, Buckley D, Hoyme HE
Drug Alcohol Depend 2011 Dec 1;119(1-2):18-27. Epub 2011 Jun 11 doi: 10.1016/j.drugalcdep.2011.05.009. [Epub ahead of print] PMID: 21658862Free PMC Article

Prognosis

Rangmar J, Hjern A, Vinnerljung B, Strömland K, Aronson M, Fahlke C
Pediatrics 2015 Jan;135(1):e52-8. Epub 2014 Dec 22 doi: 10.1542/peds.2014-1915. [Epub ahead of print] PMID: 25535260
Stoos C, Nelsen L, Schissler KA, Elliott AJ, Kinney HC
J Child Neurol 2015 Apr;30(5):601-5. Epub 2014 Feb 20 doi: 10.1177/0883073814520976. [Epub ahead of print] PMID: 24563476
Agarwal R, Mehta C, Kumar A, Maqbool M
Pediatr Neurol 2014 Aug;51(2):282-3. Epub 2014 Apr 1 doi: 10.1016/j.pediatrneurol.2014.03.026. [Epub ahead of print] PMID: 25079579
Gummel K, Ygge J
Eur J Ophthalmol 2013 Nov-Dec;23(6):823-30. Epub 2013 May 3 doi: 10.5301/ejo.5000296. [Epub ahead of print] PMID: 23661538
May PA, Tabachnick BG, Gossage JP, Kalberg WO, Marais AS, Robinson LK, Manning M, Buckley D, Hoyme HE
Drug Alcohol Depend 2011 Dec 1;119(1-2):18-27. Epub 2011 Jun 11 doi: 10.1016/j.drugalcdep.2011.05.009. [Epub ahead of print] PMID: 21658862Free PMC Article

Clinical prediction guides

Rangmar J, Sandberg AD, Aronson M, Fahlke C
Nord J Psychiatry 2015 Aug;69(6):472-8. Epub 2015 Feb 20 doi: 10.3109/08039488.2015.1009487. [Epub ahead of print] PMID: 25697067
Joya X, Garcia-Algar O, Salat-Batlle J, Pujades C, Vall O
Birth Defects Res A Clin Mol Teratol 2015 Mar;103(3):163-77. Epub 2014 Aug 18 doi: 10.1002/bdra.23290. [Epub ahead of print] PMID: 25131946
Petković G, Barišić I
Int J Environ Res Public Health 2013 Apr 16;10(4):1547-61. doi: 10.3390/ijerph10041547. PMID: 23591786Free PMC Article
Douzgou S, Breen C, Crow YJ, Chandler K, Metcalfe K, Jones E, Kerr B, Clayton-Smith J
Arch Dis Child 2012 Sep;97(9):812-7. Epub 2012 Jul 14 doi: 10.1136/archdischild-2012-302125. [Epub ahead of print] PMID: 22798695
May PA, Tabachnick BG, Gossage JP, Kalberg WO, Marais AS, Robinson LK, Manning M, Buckley D, Hoyme HE
Drug Alcohol Depend 2011 Dec 1;119(1-2):18-27. Epub 2011 Jun 11 doi: 10.1016/j.drugalcdep.2011.05.009. [Epub ahead of print] PMID: 21658862Free PMC Article

Recent systematic reviews

Landgraf MN, Nothacker M, Kopp IB, Heinen F
Dtsch Arztebl Int 2013 Oct;110(42):703-10. Epub 2013 Oct 18 doi: 10.3238/arztebl.2013.0703. PMID: 24223670Free PMC Article
Landgraf MN, Nothacker M, Heinen F
Eur J Paediatr Neurol 2013 Sep;17(5):437-46. Epub 2013 Apr 22 doi: 10.1016/j.ejpn.2013.03.008. [Epub ahead of print] PMID: 23618613
Bertrand J, Floyd LL, Weber MK; Fetal Alcohol Syndrome Prevention Team, Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC)
MMWR Recomm Rep 2005 Oct 28;54(RR-11):1-14. PMID: 16251866
Eustace LW, Kang DH, Coombs D
J Obstet Gynecol Neonatal Nurs 2003 Mar-Apr;32(2):215-21. PMID: 12685673
Burd L, Moffatt ME
Public Health Rep 1994 Sep-Oct;109(5):688-93. PMID: 7938391Free PMC Article

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