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Acne inversa

MedGen UID:
57993
Concept ID:
C0162836
Disease or Syndrome
Synonyms: Acne Inversa; Acne Inversas; Hidradenitides, Suppurative; Hidradenitis Suppurativa; Hidradenitis, Suppurative; Inversa, Acne; Inversas, Acne; Suppurative Hidradenitides; Suppurative Hidradenitis
SNOMED CT: Suppurative hidradenitis (59393003); Hidradenitis suppurativa (59393003); Hidradenitis axillaris (59393003); Apocrine acne (59393003); Verneuil's disease (59393003)
 
HPO: HP:0040154

Definition

Hidradenitis suppurativa (HS) is a chronic skin disease. It can occur in one or multiple areas of your body. HS usually develops in your armpits, groin, and anal area. It causes long-term skin inflammation and can be painful. . Symptoms include . -Blackheads and red, tender bumps, called abscesses. The abscesses get bigger, break open, and leak pus. -Tunnels that form under the skin between abscesses. -Scarring. No one knows what causes HS. It is more common in women, African Americans, and people who have had acne. It usually starts after the teenage years. Treatments include antibiotics, anti-inflammatory medicines, and sometimes surgery. Losing weight or wearing looser clothing may help some patients avoid skin irritation.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcne inversa

Conditions with this feature

Hidradenitis suppurativa, familial
MedGen UID:
326766
Concept ID:
C1840560
Disease or Syndrome
Hidradenitis suppurativa, also known as acne inversa, is a chronic skin disease characterized by recurrent boil-like lumps (nodules) under the skin. The nodules become inflamed and painful. They tend to break open (rupture), causing abscesses that drain fluid and pus. As the abscesses heal, they produce significant scarring of the skin.The signs and symptoms of hidradenitis suppurativa appear after puberty, usually in a person's teens or twenties. Nodules are most likely to form in the armpits and groin. They may also develop around the anus, on the buttocks, or under the breasts. In some cases, nodules appear in other areas, such as the nape of the neck, waist, and inner thighs.The recurrent nodules and abscesses cause chronic pain and can lead to self-consciousness, social isolation, and depression. Rarely, nodules on the buttocks can develop into a type of skin cancer called squamous cell carcinoma.
Acne inversa, familial, 2
MedGen UID:
462387
Concept ID:
C3151037
Disease or Syndrome
Acne inversa is a chronic inflammatory disease of the hair follicles whose characteristic features include draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty. Familial acne inversa is genetically heterogeneous (summary by Wang et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of acne inversa, see 142690.
Acne inversa, familial, 3
MedGen UID:
462388
Concept ID:
C3151038
Disease or Syndrome
Acne inversa is a chronic inflammatory disease of the hair follicles whose characteristic features include draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty. Familial acne inversa is genetically heterogeneous (summary by Wang et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of familial acne inversa, see 142690.

Recent clinical studies

Etiology

Danby FW
J Am Acad Dermatol 2015 Nov;73(5 Suppl 1):S52-4. doi: 10.1016/j.jaad.2015.07.042. PMID: 26470617
Nikolakis G, Join-Lambert O, Karagiannidis I, Guet-Revillet H, Zouboulis CC, Nassif A
J Am Acad Dermatol 2015 Nov;73(5 Suppl 1):S12-8. doi: 10.1016/j.jaad.2015.07.041. PMID: 26470608
Zouboulis CC, Del Marmol V, Mrowietz U, Prens EP, Tzellos T, Jemec GB
Dermatology 2015;231(2):184-90. Epub 2015 Jun 30 doi: 10.1159/000431175. [Epub ahead of print] PMID: 26139027
Wang B
J Investig Dermatol Symp Proc 2015 Jul;17(1):25. doi: 10.1038/jidsymp.2015.21. PMID: 26067312
Zouboulis CC, Desai N, Emtestam L, Hunger RE, Ioannides D, Juhász I, Lapins J, Matusiak L, Prens EP, Revuz J, Schneider-Burrus S, Szepietowski JC, van der Zee HH, Jemec GB
J Eur Acad Dermatol Venereol 2015 Apr;29(4):619-44. Epub 2015 Jan 30 doi: 10.1111/jdv.12966. [Epub ahead of print] PMID: 25640693

Diagnosis

Zouboulis CC, Del Marmol V, Mrowietz U, Prens EP, Tzellos T, Jemec GB
Dermatology 2015;231(2):184-90. Epub 2015 Jun 30 doi: 10.1159/000431175. [Epub ahead of print] PMID: 26139027
Zouboulis CC, Desai N, Emtestam L, Hunger RE, Ioannides D, Juhász I, Lapins J, Matusiak L, Prens EP, Revuz J, Schneider-Burrus S, Szepietowski JC, van der Zee HH, Jemec GB
J Eur Acad Dermatol Venereol 2015 Apr;29(4):619-44. Epub 2015 Jan 30 doi: 10.1111/jdv.12966. [Epub ahead of print] PMID: 25640693
Dessinioti C, Katsambas A, Antoniou C
Clin Dermatol 2014 May-Jun;32(3):397-408. Epub 2013 Nov 22 doi: 10.1016/j.clindermatol.2013.11.006. [Epub ahead of print] PMID: 24767187
Vossen MG, Gattringer KB, Khalifeh N, Koreny M, Spertini V, Mallouhi A, Willeit M, Volc-Platzer B, Asboth F, Graninger W, Thalhammer F, Lagler H
J Clin Microbiol 2012 Mar;50(3):1109-12. Epub 2011 Dec 21 doi: 10.1128/JCM.06161-11. [Epub ahead of print] PMID: 22189120Free PMC Article
von Laffert M, Stadie V, Wohlrab J, Marsch WC
Br J Dermatol 2011 Feb;164(2):367-71. Epub 2010 Nov 23 doi: 10.1111/j.1365-2133.2010.10034.x. [Epub ahead of print] PMID: 20831631

Therapy

Nikolakis G, Join-Lambert O, Karagiannidis I, Guet-Revillet H, Zouboulis CC, Nassif A
J Am Acad Dermatol 2015 Nov;73(5 Suppl 1):S12-8. doi: 10.1016/j.jaad.2015.07.041. PMID: 26470608
Zouboulis CC, Del Marmol V, Mrowietz U, Prens EP, Tzellos T, Jemec GB
Dermatology 2015;231(2):184-90. Epub 2015 Jun 30 doi: 10.1159/000431175. [Epub ahead of print] PMID: 26139027
Savaşan S, El-Baba M
J Pediatr Gastroenterol Nutr 2013 Jan;56(1):e2-3. doi: 10.1097/MPG.0b013e3182474d78. PMID: 22197950
Vossen MG, Gattringer KB, Khalifeh N, Koreny M, Spertini V, Mallouhi A, Willeit M, Volc-Platzer B, Asboth F, Graninger W, Thalhammer F, Lagler H
J Clin Microbiol 2012 Mar;50(3):1109-12. Epub 2011 Dec 21 doi: 10.1128/JCM.06161-11. [Epub ahead of print] PMID: 22189120Free PMC Article
CESKO E, KORBER A, DISSEMOND J
Eur J Dermatol 2009 Sep-Oct;19(5):490-3. Epub 2009 Jun 15 doi: 10.1684/ejd.2009.0710. [Epub ahead of print] PMID: 19527985

Prognosis

Danby FW
J Am Acad Dermatol 2015 Nov;73(5 Suppl 1):S52-4. doi: 10.1016/j.jaad.2015.07.042. PMID: 26470617
Nikolakis G, Join-Lambert O, Karagiannidis I, Guet-Revillet H, Zouboulis CC, Nassif A
J Am Acad Dermatol 2015 Nov;73(5 Suppl 1):S12-8. doi: 10.1016/j.jaad.2015.07.041. PMID: 26470608
Kurek A, Johanne Peters EM, Sabat R, Sterry W, Schneider-Burrus S
J Dtsch Dermatol Ges 2013 Aug;11(8):743-9, 743-50. Epub 2013 Apr 9 doi: 10.1111/ddg.12067. [Epub ahead of print] PMID: 23565584
Boer J, Nazary M
Br J Dermatol 2011 Jan;164(1):170-5. doi: 10.1111/j.1365-2133.2010.10071.x. PMID: 20874789
Goertz RS, Konturek PC, Naegel A, Janka R, Amann K, Maennlein G, Wein A, Hahn EG, Boxberger F
Med Sci Monit 2009 Jan;15(1):CS14-8. PMID: 19114971

Clinical prediction guides

Danby FW
J Am Acad Dermatol 2015 Nov;73(5 Suppl 1):S52-4. doi: 10.1016/j.jaad.2015.07.042. PMID: 26470617
Kurek A, Johanne Peters EM, Sabat R, Sterry W, Schneider-Burrus S
J Dtsch Dermatol Ges 2013 Aug;11(8):743-9, 743-50. Epub 2013 Apr 9 doi: 10.1111/ddg.12067. [Epub ahead of print] PMID: 23565584
Sabat R, Chanwangpong A, Schneider-Burrus S, Metternich D, Kokolakis G, Kurek A, Philipp S, Uribe D, Wolk K, Sterry W
PLoS One 2012;7(2):e31810. Epub 2012 Feb 16 doi: 10.1371/journal.pone.0031810. PMID: 22359634Free PMC Article
Emelianov VU, Bechara FG, Gläser R, Langan EA, Taungjaruwinai WM, Schröder JM, Meyer KC, Paus R
Br J Dermatol 2012 May;166(5):1023-34. Epub 2012 Apr 4 doi: 10.1111/j.1365-2133.2011.10765.x. [Epub ahead of print] PMID: 22136668
Wollina U, Tilp M, Meseg A, Schönlebe J, Heinig B, Nowak A
Dermatol Surg 2012 Jan;38(1):110-7. Epub 2011 Sep 14 doi: 10.1111/j.1524-4725.2011.02157.x. [Epub ahead of print] PMID: 22092781

Recent systematic reviews

Woodruff CM, Charlie AM, Leslie KS
Mayo Clin Proc 2015 Dec;90(12):1679-93. doi: 10.1016/j.mayocp.2015.08.020. PMID: 26653298
Gerard AJ, Feldman SR, Strowd L
J Cutan Med Surg 2015 Jul-Aug;19(4):391-6. Epub 2015 Mar 5 doi: 10.1177/1203475415575013. [Epub ahead of print] PMID: 25775617
Scheinfeld N
Dermatol Online J 2015 Jan 15;21(1) PMID: 25612117
Haslund P, Lee RA, Jemec GB
Acta Derm Venereol 2009 Nov;89(6):595-600. doi: 10.2340/00015555-0747. PMID: 19997689

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