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Metaiodobenzylguanidine

MedGen UID:
12998
Concept ID:
C0047506
Pharmacologic Substance
Synonyms: 3 Iodobenzylguanidine; 3-Iodobenzylguanidine; Iobenguane; m Iodobenzylguanidine; m-Iodobenzylguanidine; meta Iodobenzylguanidine; meta-Iodobenzylguanidine; MIBG
SNOMED CT: Metaiodobenzylguanidine (395786000); Iobenguane (395786000)
 

Definition

A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase. [from MeSH]

Recent clinical studies

Etiology

Clement SC, Kraal KC, van Eck-Smit BL, van den Bos C, Kremer LC, Tytgat GA, van Santen HM
J Clin Endocrinol Metab 2014 Jan;99(1):E112-6. Epub 2013 Dec 4 doi: 10.1210/jc.2013-3595. [Epub ahead of print] PMID: 24187404
Nakata T, Hashimoto A, Sugawara H
Curr Heart Fail Rep 2013 Dec;10(4):359-64. doi: 10.1007/s11897-013-0161-9. PMID: 24091807
Clement SC, van Eck-Smit BL, van Trotsenburg AS, Kremer LC, Tytgat GA, van Santen HM
Pediatr Blood Cancer 2013 Nov;60(11):1833-8. Epub 2013 Jul 6 doi: 10.1002/pbc.24681. [Epub ahead of print] PMID: 23832530
Martins da Silva MI, Vidigal Ferreira MJ, Morão Moreira AP
Rev Port Cardiol 2013 Jun;32(6):509-16. Epub 2013 Jun 2 doi: 10.1016/j.repc.2012.11.003. [Epub ahead of print] PMID: 23731734
Inoue Y, Abe Y, Itoh Y, Asano Y, Kikuchi K, Sakamoto Y, Matsunaga K, Ogino Y, Iizuka T, Mochizuki H
J Nucl Med 2013 May;54(5):707-13. Epub 2013 Mar 27 doi: 10.2967/jnumed.112.111955. [Epub ahead of print] PMID: 23536225

Diagnosis

Clement SC, Kraal KC, van Eck-Smit BL, van den Bos C, Kremer LC, Tytgat GA, van Santen HM
J Clin Endocrinol Metab 2014 Jan;99(1):E112-6. Epub 2013 Dec 4 doi: 10.1210/jc.2013-3595. [Epub ahead of print] PMID: 24187404
Clement SC, van Eck-Smit BL, van Trotsenburg AS, Kremer LC, Tytgat GA, van Santen HM
Pediatr Blood Cancer 2013 Nov;60(11):1833-8. Epub 2013 Jul 6 doi: 10.1002/pbc.24681. [Epub ahead of print] PMID: 23832530
Miyoshi F, Ogawa T, Kitao SI, Kitayama M, Shinohara Y, Takasugi M, Fujii S, Kaminou T
AJNR Am J Neuroradiol 2013 Nov-Dec;34(11):2113-8. Epub 2013 Jun 6 doi: 10.3174/ajnr.A3567. [Epub ahead of print] PMID: 23744697
Martins da Silva MI, Vidigal Ferreira MJ, Morão Moreira AP
Rev Port Cardiol 2013 Jun;32(6):509-16. Epub 2013 Jun 2 doi: 10.1016/j.repc.2012.11.003. [Epub ahead of print] PMID: 23731734
Asayama S, Wate R, Kaneko S, Asayama T, Oki M, Tsuge A, Nagashima M, Morita J, Nakamura S, Nakamura M, Nishii M, Fujita K, Saito A, Nakano S, Ito H, Kusaka H
Acta Neurol Scand 2013 Sep;128(3):160-5. Epub 2013 Feb 15 doi: 10.1111/ane.12104. [Epub ahead of print] PMID: 23410225

Therapy

Clement SC, Kraal KC, van Eck-Smit BL, van den Bos C, Kremer LC, Tytgat GA, van Santen HM
J Clin Endocrinol Metab 2014 Jan;99(1):E112-6. Epub 2013 Dec 4 doi: 10.1210/jc.2013-3595. [Epub ahead of print] PMID: 24187404
Bleeker G, Schoot RA, Caron HN, de Kraker J, Hoefnagel CA, van Eck BL, Tytgat GA
Eur J Nucl Med Mol Imaging 2013 Oct;40(11):1711-7. Epub 2013 Aug 7 doi: 10.1007/s00259-013-2510-z. [Epub ahead of print] PMID: 23921531Free PMC Article
Clement SC, van Eck-Smit BL, van Trotsenburg AS, Kremer LC, Tytgat GA, van Santen HM
Pediatr Blood Cancer 2013 Nov;60(11):1833-8. Epub 2013 Jul 6 doi: 10.1002/pbc.24681. [Epub ahead of print] PMID: 23832530
Miyoshi F, Ogawa T, Kitao SI, Kitayama M, Shinohara Y, Takasugi M, Fujii S, Kaminou T
AJNR Am J Neuroradiol 2013 Nov-Dec;34(11):2113-8. Epub 2013 Jun 6 doi: 10.3174/ajnr.A3567. [Epub ahead of print] PMID: 23744697
Asayama S, Wate R, Kaneko S, Asayama T, Oki M, Tsuge A, Nagashima M, Morita J, Nakamura S, Nakamura M, Nishii M, Fujita K, Saito A, Nakano S, Ito H, Kusaka H
Acta Neurol Scand 2013 Sep;128(3):160-5. Epub 2013 Feb 15 doi: 10.1111/ane.12104. [Epub ahead of print] PMID: 23410225

Prognosis

Clement SC, Kraal KC, van Eck-Smit BL, van den Bos C, Kremer LC, Tytgat GA, van Santen HM
J Clin Endocrinol Metab 2014 Jan;99(1):E112-6. Epub 2013 Dec 4 doi: 10.1210/jc.2013-3595. [Epub ahead of print] PMID: 24187404
Nakata T, Hashimoto A, Sugawara H
Curr Heart Fail Rep 2013 Dec;10(4):359-64. doi: 10.1007/s11897-013-0161-9. PMID: 24091807
Martins da Silva MI, Vidigal Ferreira MJ, Morão Moreira AP
Rev Port Cardiol 2013 Jun;32(6):509-16. Epub 2013 Jun 2 doi: 10.1016/j.repc.2012.11.003. [Epub ahead of print] PMID: 23731734
Nakae I, Hayashi H, Mitsunami K, Horie M
Ann Nucl Med 2013 Oct;27(8):737-47. Epub 2013 Jun 1 doi: 10.1007/s12149-013-0741-5. [Epub ahead of print] PMID: 23728513
Asayama S, Wate R, Kaneko S, Asayama T, Oki M, Tsuge A, Nagashima M, Morita J, Nakamura S, Nakamura M, Nishii M, Fujita K, Saito A, Nakano S, Ito H, Kusaka H
Acta Neurol Scand 2013 Sep;128(3):160-5. Epub 2013 Feb 15 doi: 10.1111/ane.12104. [Epub ahead of print] PMID: 23410225

Clinical prediction guides

Clement SC, Kraal KC, van Eck-Smit BL, van den Bos C, Kremer LC, Tytgat GA, van Santen HM
J Clin Endocrinol Metab 2014 Jan;99(1):E112-6. Epub 2013 Dec 4 doi: 10.1210/jc.2013-3595. [Epub ahead of print] PMID: 24187404
Nakata T, Hashimoto A, Sugawara H
Curr Heart Fail Rep 2013 Dec;10(4):359-64. doi: 10.1007/s11897-013-0161-9. PMID: 24091807
De Rosa A, Pappatà S, Pellegrino T, De Leva MF, Maddaluno G, Fiumara G, Carotenuto R, Petretta M, Filla A, De Michele G, Cuocolo A
Eur J Nucl Med Mol Imaging 2013 Dec;40(12):1914-21. Epub 2013 Aug 9 doi: 10.1007/s00259-013-2524-6. [Epub ahead of print] PMID: 23929432
Bleeker G, Schoot RA, Caron HN, de Kraker J, Hoefnagel CA, van Eck BL, Tytgat GA
Eur J Nucl Med Mol Imaging 2013 Oct;40(11):1711-7. Epub 2013 Aug 7 doi: 10.1007/s00259-013-2510-z. [Epub ahead of print] PMID: 23921531Free PMC Article
Asayama S, Wate R, Kaneko S, Asayama T, Oki M, Tsuge A, Nagashima M, Morita J, Nakamura S, Nakamura M, Nishii M, Fujita K, Saito A, Nakano S, Ito H, Kusaka H
Acta Neurol Scand 2013 Sep;128(3):160-5. Epub 2013 Feb 15 doi: 10.1111/ane.12104. [Epub ahead of print] PMID: 23410225

Recent systematic reviews

Castellani MR, Aktolun C, Buzzoni R, Seregni E, Chiesa C, Maccauro M, Aliberti GL, Vellani C, Lorenzoni A, Bombardieri E
Q J Nucl Med Mol Imaging 2013 Jun;57(2):146-52. PMID: 23822990
Rufini V, Treglia G, Castaldi P, Perotti G, Giordano A
Q J Nucl Med Mol Imaging 2013 Jun;57(2):122-33. PMID: 23822989
van Hulsteijn LT, Corssmit EP, van der Hiel B, Smit JW, Stokkel MP
Clin Nucl Med 2012 Nov;37(11):1083-8. doi: 10.1097/RLU.0b013e318266cb3d. PMID: 22996242
Treglia G, Stefanelli A, Cason E, Cocciolillo F, Di Giuda D, Giordano A
Clin Neurol Neurosurg 2011 Dec;113(10):823-9. Epub 2011 Oct 2 doi: 10.1016/j.clineuro.2011.09.004. [Epub ahead of print] PMID: 21962800
Flotats A, Carrió I, Agostini D, Le Guludec D, Marcassa C, Schäfers M, Somsen GA, Unlu M, Verberne HJ; EANM Cardiovascular Committee; European Council of Nuclear Cardiology
Eur J Nucl Med Mol Imaging 2010 Aug;37(9):1802-12. doi: 10.1007/s00259-010-1491-4. PMID: 20577740

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