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Results: 18

1.

Inflammation

A microscopic finding indicating the presence of acute, subacute or chronic inflammation in a tissue sample. [from NCI]

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
2.

Threonine

An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins. [from MeSH]

MedGen UID:
52734
Concept ID:
C0040005
Pharmacologic Substance
3.

Serine

A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04) [from NCI]

MedGen UID:
11382
Concept ID:
C0036720
Pharmacologic Substance
4.

Phosphorylation

A process in which a phosphate group is added to a molecule, such as a sugar or a protein. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
5.

Agonist

A drug or substance that binds to a receptor inside a cell or on its surface and causes the same action as the substance that normally binds to the receptor. [from NCI]

MedGen UID:
459858
Concept ID:
C2987634
Pharmacologic Substance
6.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
7.

Nuclear Translocation

Nuclear Translocation is a subcellular process in which activated cytoplasmic proteins are transported into the cell nucleus as part of a signal transduction pathway to modify cell function (typically gene expression) in response to a signaling event or condition. [from NCI]

MedGen UID:
273609
Concept ID:
C1518440
Molecular Function
8.

G Protein-Coupled Receptor Signaling

G Protein-Coupled Receptor (GPCR) Signaling involves interactions of agonists with seven membrane-spanning receptors that induce receptor interaction with a heterotrimeric GTP-binding (G) protein complex, activation of GDP-GTP exchange on the G protein Ga subunit, dissociation of Ga from the Gbg heterodimer, and interaction of the subunits with intracellular effectors causing signal transduction cascades. GPCRs are coupled to different G protein subtypes that can activate or inhibit adenylyl cyclase, ion channels, PLC, PKC, CaM-KII, MAPKs, Src kinases, PI(3)K, Pyk2 and/or FAK in such diverse processes as neurotransmission, cellular metabolism, cell differentiation, cell proliferation, and immune responses. [from NCI]

MedGen UID:
273354
Concept ID:
C1517377
Molecular Function
9.

Receptor Signaling

An intercellular process that involves a cellular receptor binding to a cognate ligand and results in a specific cellular response. [from NCI]

MedGen UID:
271464
Concept ID:
C1514762
Molecular Function
10.

Inflammatory Response

A part of innate immunity, the Inflammatory Response occurs when injured tissues induce release of vasodilatory, opsonizing, and chemotactic mediators that attract macrophages and leukocytes to phagocytize and destroy foreign substances; dilate local blood vessels increasing local blood flow; increase capillary permeability; produce edematous swelling; and induce pain. Plasma- and cell-derived inflammatory mediators include Prostaglandins, Leukotrines, Cytokines, Lymphokines, Monokines, PAF, Histamine, Bradykinin, Complement, and Interferons. [from NCI]

MedGen UID:
218869
Concept ID:
C1155266
Pathologic Function
11.

agonists

Used with chemicals, drugs, and endogenous substances to indicate substances or agents that have affinity for a receptor and intrinsic activity at that receptor. (From Textbook of Pharmacology, 1991, p.16) [from MeSH]

MedGen UID:
116746
Concept ID:
C0243192
Pharmacologic Substance
12.

Infiltration

morphologic abnormality [from CHV]

MedGen UID:
83059
Concept ID:
C0332448
Pathologic Function
13.

Van der Woude syndrome

IRF6-related disorders span a spectrum from isolated cleft lip and palate and Van der Woude syndrome (VWS) at the mild end to popliteal pterygium syndrome (PPS) at the more severe end. Individuals with VWS show one or more of the following anomalies: Congenital, usually bilateral, paramedian lower-lip fistulae (pits) or sometimes small mounds with a sinus tract leading from a mucous gland of the lip. Cleft lip (CL). Cleft palate (CP)?Note: Cleft lip with or without cleft palate (CL±P) is observed about twice as often as CP only. Submucous cleft palate (SMCP). The PPS phenotype includes the following: CL±P . Fistulae of the lower lip . Webbing of the skin extending from the ischial tuberosities to the heels . In males: bifid scrotum and cryptorchidism. In females: hypoplasia of the labia majora. Syndactyly of fingers and/or toes . Anomalies of the skin around the nails. A characteristic pyramidal fold of skin overlying the nail of the hallux (almost pathognomonic) . In some non-classic forms of PPS: filiform synechiae connecting the upper and lower jaws (syngnathia) or the upper and lower eyelids (ankyloblepharon) . In both VWS and PPS, growth and intelligence are normal. [from GeneReviews]

MedGen UID:
61233
Concept ID:
C0175697
Disease or Syndrome
14.

Sugar

A white crystalline carbohydrate, typically sucrose, used as a sweetener and preservative. [from NCI]

MedGen UID:
69157
Concept ID:
C0242209
Pharmacologic Substance
15.

Mediator of inflammation

The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC). [from MeSH]

MedGen UID:
66209
Concept ID:
C0243042
Pharmacologic Substance
16.

Polysaccharide

A large carbohydrate molecule. It contains many small sugar molecules that are joined chemically. [from NCI]

MedGen UID:
46014
Concept ID:
C0032594
Pharmacologic Substance
17.

Pathologic Processes

The abnormal mechanisms and forms involved in the dysfunctions of tissues and organs. [from MeSH]

MedGen UID:
18325
Concept ID:
C0030660
Pathologic Function
18.

Serine/Threonine Kinase Inhibitor XL418

A selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells. [from NCI]

MedGen UID:
384966
Concept ID:
C2348194
Pharmacologic Substance

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