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T-Cell Antigen Receptor Specificity

MedGen UID:
210169
Concept ID:
C1136158
Molecular Function
Synonyms: Specificity, T-Cell Receptor; T Cell Antigen Receptor Specificity; T Cell Receptor Specificity; T-Cell Receptor Specificity
 

Definition

The property of the T-CELL RECEPTOR which enables it to react with some antigens and not others. The specificity is derived from the structure of the receptor's variable region which has the ability to recognize certain antigens in conjunction with the MAJOR HISTOCOMPATIBILITY COMPLEX molecule. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGT-Cell Antigen Receptor Specificity

Recent clinical studies

Etiology

LaVoy EC, Bollard CM, Hanley PJ, Blaney JW, O'Connor DP, Bosch JA, Simpson RJ
Exerc Immunol Rev 2015;21:144-53. PMID: 25826370
Musson JA, Reynolds CJ, Rinchai D, Nithichanon A, Khaenam P, Favry E, Spink N, Chu KK, De Soyza A, Bancroft GJ, Lertmemongkolchai G, Maillere B, Boyton RJ, Altmann DM, Robinson JH
J Immunol 2014 Dec 15;193(12):6041-9. Epub 2014 Nov 12 doi: 10.4049/jimmunol.1402273. [Epub ahead of print] PMID: 25392525Free PMC Article
Conti F, Spinelli FR, Alessandri C, Pacelli M, Ceccarelli F, Marocchi E, Montali A, Capozzi A, Buttari B, Profumo E, Sorice M, Arca M, Valesini G, Riganò R
Arterioscler Thromb Vasc Biol 2014 Mar;34(3):661-8. Epub 2014 Jan 16 doi: 10.1161/ATVBAHA.113.302680. [Epub ahead of print] PMID: 24436371
van Loenen MM, de Boer R, van Liempt E, Meij P, Jedema I, Falkenburg JH, Heemskerk MH
Haematologica 2014 Apr;99(4):759-68. Epub 2013 Dec 13 doi: 10.3324/haematol.2013.093690. [Epub ahead of print] PMID: 24334296Free PMC Article
Humphreys IS, von Delft A, Brown A, Hibbert L, Collier JD, Foster GR, Rahman M, Christian A, Klenerman P, Barnes E
Gut 2012 Nov;61(11):1589-99. Epub 2012 Feb 15 doi: 10.1136/gutjnl-2011-300650. [Epub ahead of print] PMID: 22337948Free PMC Article

Diagnosis

Wang Y, Zhang WY, Han QW, Liu Y, Dai HR, Guo YL, Bo J, Fan H, Zhang Y, Zhang YJ, Chen MX, Feng KC, Wang QS, Fu XB, Han WD
Clin Immunol 2014 Dec;155(2):160-75. Epub 2014 Oct 16 doi: 10.1016/j.clim.2014.10.002. [Epub ahead of print] PMID: 25444722
Ostadkarampour M, Eklund A, Moller D, Glader P, Olgart Höglund C, Lindén A, Grunewald J, Wahlström J
Clin Exp Immunol 2014 Nov;178(2):342-52. doi: 10.1111/cei.12403. PMID: 24962673Free PMC Article
Chapuis AG, Afanasiev OK, Iyer JG, Paulson KG, Parvathaneni U, Hwang JH, Lai I, Roberts IM, Sloan HL, Bhatia S, Shibuya KC, Gooley T, Desmarais C, Koelle DM, Yee C, Nghiem P
Cancer Immunol Res 2014 Jan;2(1):27-36. doi: 10.1158/2326-6066.CIR-13-0087. PMID: 24432305Free PMC Article
Madura F, Rizkallah PJ, Miles KM, Holland CJ, Bulek AM, Fuller A, Schauenburg AJ, Miles JJ, Liddy N, Sami M, Li Y, Hossain M, Baker BM, Jakobsen BK, Sewell AK, Cole DK
J Biol Chem 2013 Jun 28;288(26):18766-75. Epub 2013 May 22 doi: 10.1074/jbc.M113.464560. [Epub ahead of print] PMID: 23698002Free PMC Article
Humphreys IS, von Delft A, Brown A, Hibbert L, Collier JD, Foster GR, Rahman M, Christian A, Klenerman P, Barnes E
Gut 2012 Nov;61(11):1589-99. Epub 2012 Feb 15 doi: 10.1136/gutjnl-2011-300650. [Epub ahead of print] PMID: 22337948Free PMC Article

Therapy

Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M
J Immunol 2015 Feb 1;194(3):911-20. Epub 2014 Dec 17 doi: 10.4049/jimmunol.1402346. [Epub ahead of print] PMID: 25520398
Wang Y, Zhang WY, Han QW, Liu Y, Dai HR, Guo YL, Bo J, Fan H, Zhang Y, Zhang YJ, Chen MX, Feng KC, Wang QS, Fu XB, Han WD
Clin Immunol 2014 Dec;155(2):160-75. Epub 2014 Oct 16 doi: 10.1016/j.clim.2014.10.002. [Epub ahead of print] PMID: 25444722
Bedke T, Iannitti RG, De Luca A, Giovannini G, Fallarino F, Berges C, Latgé JP, Einsele H, Romani L, Topp MS
Immunol Cell Biol 2014 Sep;92(8):659-70. Epub 2014 May 13 doi: 10.1038/icb.2014.34. [Epub ahead of print] PMID: 24820384Free PMC Article
Geyeregger R, Freimüller C, Stemberger J, Artwohl M, Witt V, Lion T, Fischer G, Lawitschka A, Ritter J, Hummel M, Holter W, Fritsch G, Matthes-Martin S
J Immunother 2014 May;37(4):245-9. doi: 10.1097/CJI.0000000000000034. PMID: 24714358
van Loenen MM, de Boer R, van Liempt E, Meij P, Jedema I, Falkenburg JH, Heemskerk MH
Haematologica 2014 Apr;99(4):759-68. Epub 2013 Dec 13 doi: 10.3324/haematol.2013.093690. [Epub ahead of print] PMID: 24334296Free PMC Article

Prognosis

Mata M, Vera JF, Gerken C, Rooney CM, Miller T, Pfent C, Wang LL, Wilson-Robles HM, Gottschalk S
J Immunother 2014 Oct;37(8):407-15. doi: 10.1097/CJI.0000000000000052. PMID: 25198528Free PMC Article
Ostadkarampour M, Eklund A, Moller D, Glader P, Olgart Höglund C, Lindén A, Grunewald J, Wahlström J
Clin Exp Immunol 2014 Nov;178(2):342-52. doi: 10.1111/cei.12403. PMID: 24962673Free PMC Article
Karbach J, Gnjatic S, Biskamp M, Atmaca A, Weidmann E, Brandt K, Wahle C, Bernhard H, Knuth A, Jäger E
Cancer Immunol Res 2014 May;2(5):404-9. Epub 2014 Feb 5 doi: 10.1158/2326-6066.CIR-13-0200. [Epub ahead of print] PMID: 24795353
Geyeregger R, Freimüller C, Stemberger J, Artwohl M, Witt V, Lion T, Fischer G, Lawitschka A, Ritter J, Hummel M, Holter W, Fritsch G, Matthes-Martin S
J Immunother 2014 May;37(4):245-9. doi: 10.1097/CJI.0000000000000034. PMID: 24714358
Ayasoufi K, Yu H, Fan R, Wang X, Williams J, Valujskikh A
Am J Transplant 2013 Mar;13(3):589-99. Epub 2013 Jan 17 doi: 10.1111/ajt.12068. [Epub ahead of print] PMID: 23331999Free PMC Article

Clinical prediction guides

LaVoy EC, Bollard CM, Hanley PJ, Blaney JW, O'Connor DP, Bosch JA, Simpson RJ
Exerc Immunol Rev 2015;21:144-53. PMID: 25826370
Mata M, Vera JF, Gerken C, Rooney CM, Miller T, Pfent C, Wang LL, Wilson-Robles HM, Gottschalk S
J Immunother 2014 Oct;37(8):407-15. doi: 10.1097/CJI.0000000000000052. PMID: 25198528Free PMC Article
Ostadkarampour M, Eklund A, Moller D, Glader P, Olgart Höglund C, Lindén A, Grunewald J, Wahlström J
Clin Exp Immunol 2014 Nov;178(2):342-52. doi: 10.1111/cei.12403. PMID: 24962673Free PMC Article
Klar R, Schober S, Rami M, Mall S, Merl J, Hauck SM, Ueffing M, Admon A, Slotta-Huspenina J, Schwaiger M, Stevanović S, Oostendorp RA, Busch DH, Peschel C, Krackhardt AM
Leukemia 2014 Dec;28(12):2355-66. Epub 2014 Apr 16 doi: 10.1038/leu.2014.131. [Epub ahead of print] PMID: 24736212
Plesa G, Zheng L, Medvec A, Wilson CB, Robles-Oteiza C, Liddy N, Bennett AD, Gavarret J, Vuidepot A, Zhao Y, Blazar BR, Jakobsen BK, Riley JL
Blood 2012 Apr 12;119(15):3420-30. Epub 2012 Feb 7 doi: 10.1182/blood-2011-09-377051. [Epub ahead of print] PMID: 22318202Free PMC Article

Recent systematic reviews

Lévy F, Colombetti S
Int Rev Immunol 2006 Sep-Dec;25(5-6):269-95. doi: 10.1080/08830180600992407. PMID: 17169777

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