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Results: 1 to 20 of 30

1.

Buprenorphine

A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use. [from MeSH]

MedGen UID:
14252
Concept ID:
C0006405
Pharmacologic Substance
2.

Methadone

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3) [from MeSH]

MedGen UID:
6335
Concept ID:
C0025605
Pharmacologic Substance
3.

Opioid Receptor Agonist

Any agent that binds to and activates any of the opioid receptor subtypes. Opioid receptor agonists mimic the actions of endogenous opioid peptides. [from NCI]

MedGen UID:
760844
Concept ID:
C3537230
Pharmacologic Substance
4.

Indicated

MedGen UID:
731837
Concept ID:
C1444656
Finding
5.

Agonist

An agent that has affinity for a receptor and intrinsic activity at that receptor. [from NCI]

MedGen UID:
459858
Concept ID:
C2987634
Pharmacologic Substance
6.

Carney complex, type 1

Carney complex (CNC) is characterized by skin pigmentary abnormalities, myxomas, endocrine tumors or overactivity, and schwannomas. Pale brown to black lentigines are the most common presenting feature of CNC and typically increase in number at puberty. Cardiac myxomas occur at a young age, may occur in any or all cardiac chambers, and manifest as intracardiac obstruction of blood flow, embolic phenomena, and/or heart failure. Other sites for myxomas include the skin, breast, oropharynx, and female genital tract. Primary pigmented nodular adrenocortical disease (PPNAD), which causes Cushing syndrome, is the most frequently observed endocrine tumor in CNC, occurring in approximately 25% of affected individuals. Large-cell calcifying Sertoli cell tumors (LCCSCTs) are observed in one third of affected males within the first decade and in almost all adult males. Up to 75% of individuals with CNC have multiple thyroid nodules, most of which are thyroid follicular adenomas. Clinically evident acromegaly from a growth hormone (GH)-producing adenoma is evident in approximately 10% of adults. Psammomatous melanotic schwannoma (PMS), a rare tumor of the nerve sheath, occurs in an estimated 10% of affected individuals. The median age of diagnosis is 20 years. [from GeneReviews]

MedGen UID:
388559
Concept ID:
C2607929
Disease or Syndrome
7.

Opioid Agonist [EPC]

MedGen UID:
365319
Concept ID:
C1883695
Pharmacologic Substance
8.

Caronte

MedGen UID:
349004
Concept ID:
C1858724
9.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
10.

Dependence

The psychological or physiological need to take a substance in oder to experience its effects or to avoid the effects of its absence. [from NCI]

MedGen UID:
141006
Concept ID:
C0439857
Mental or Behavioral Dysfunction
11.

agonists

Used with chemicals, drugs, and endogenous substances to indicate substances or agents that have affinity for a receptor and intrinsic activity at that receptor. (From Textbook of Pharmacology, 1991, p.16) [from MeSH]

MedGen UID:
116746
Concept ID:
C0243192
Pharmacologic Substance
12.

Opioid dependence

MedGen UID:
99372
Concept ID:
C0524662
Mental or Behavioral Dysfunction
13.

Opiate agonist

A family of synthetic drugs used to treat moderate to severe pain. They are similar to opiates such as morphine and codeine. [from NCI]

MedGen UID:
66892
Concept ID:
C0242402
Pharmacologic Substance
14.

Prefin

MedGen UID:
260900
Concept ID:
C1450937
Pharmacologic Substance
15.

6029-M

MedGen UID:
196432
Concept ID:
C0729137
Pharmacologic Substance
16.

Buprenex

MedGen UID:
152319
Concept ID:
C0701441
Pharmacologic Substance
17.

Revivon

MedGen UID:
84327
Concept ID:
C0282146
Pharmacologic Substance
18.

Sensory System Agents

Drugs that act on neuronal sensory receptors resulting in an increase, decrease, or modification of afferent nerve activity. (From Smith and Reynard, Textbook of Pharmacology, 1991, p367) [from MeSH]

MedGen UID:
67054
Concept ID:
C0243058
Pharmacologic Substance
19.

Peripheral Nervous System Agents

Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75) [from MeSH]

MedGen UID:
67048
Concept ID:
C0243049
Pharmacologic Substance
20.

Opiate Alkaloids

Alkaloids found in OPIUM from PAPAVER that induce analgesic and narcotic effects by action upon OPIOID RECEPTORS. [from MeSH]

MedGen UID:
66385
Concept ID:
C0221793
Pharmacologic Substance

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