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Results: 4

1.

rosuvastatin

A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades. [from NCI]

MedGen UID:
193021
Concept ID:
C0965129
Pharmacologic Substance
2.

sildenafil

A drug used to treat erectile dysfunction. Sildenafil relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase inhibitor. [from NCI]

MedGen UID:
102095
Concept ID:
C0529793
Pharmacologic Substance
3.

Rhabdomyolysis

Necrosis or disintegration of skeletal muscle often followed by myoglobinuria. [from MeSH]

MedGen UID:
19775
Concept ID:
C0035410
Pathologic Function
4.

Rhabdomyolysis

Breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream. [from HPO]

MedGen UID:
505480
Concept ID:
CN002889
Finding

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