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Influenza

MedGen UID:
9466
Concept ID:
C0021400
Disease or Syndrome
Synonyms: Flu, Human; Grippe; Human Flu; Human Influenza; Human Influenzas; Influenza in Human; Influenza in Humans; Influenza, Human; Influenzas; Influenzas, Human
SNOMED CT: Influenza (6142004); Flu (6142004); Grippe (6142004)
 
Gene: IFITM3
Cytogenetic location: 11p15.5
OMIM: 614680

Definition

An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia. [from MeSH]

Recent clinical studies

Etiology

Falsey AR, McElhaney JE, Beran J, van Essen GA, Duval X, Esen M, Galtier F, Gervais P, Hwang SJ, Kremsner P, Launay O, Leroux-Roels G, McNeil SA, Nowakowski A, Richardus JH, Ruiz-Palacios G, St Rose S, Devaster JM, Oostvogels L, Durviaux S, Taylor S
J Infect Dis 2014 Jun 15;209(12):1873-81. Epub 2014 Jan 29 doi: 10.1093/infdis/jit839. [Epub ahead of print] PMID: 24482398Free PMC Article
Fowlkes A, Giorgi A, Erdman D, Temte J, Goodin K, Di Lonardo S, Sun Y, Martin K, Feist M, Linz R, Boulton R, Bancroft E, McHugh L, Lojo J, Filbert K, Finelli L; IISP Working Group
J Infect Dis 2014 Jun 1;209(11):1715-25. Epub 2013 Dec 12 doi: 10.1093/infdis/jit806. [Epub ahead of print] PMID: 24338352
Zhong W, Reed C, Blair PJ, Katz JM, Hancock K; Influenza Serology Working Group
J Infect Dis 2014 Apr 1;209(7):986-94. Epub 2013 Dec 10 doi: 10.1093/infdis/jit811. [Epub ahead of print] PMID: 24325965
Takashita E, Fujisaki S, Kishida N, Xu H, Imai M, Tashiro M, Odagiri T; Influenza Virus Surveillance Group of Japan
Influenza Other Respir Viruses 2013 Nov;7(6):1390-9. Epub 2013 Jun 8 doi: 10.1111/irv.12132. [Epub ahead of print] PMID: 23745712
Kennedy ED, Roy M, Norris J, Fry AM, Kanzaria M, Blau DM, Shieh WJ, Zaki SR, Waller K, Kamimoto L, Finelli L, Jhung MA; 2009 Pandemic H1N1 Influenza-Associated Lower Respiratory Tract Hemorrhage Working Group
Influenza Other Respir Viruses 2013 Sep;7(5):761-5. Epub 2012 Dec 20 doi: 10.1111/irv.12026. [Epub ahead of print] PMID: 23279922

Diagnosis

Yang H, Chang JC, Guo Z, Carney PJ, Shore DA, Donis RO, Cox NJ, Villanueva JM, Klimov AI, Stevens J
J Virol 2014 May;88(9):4828-38. Epub 2014 Feb 12 doi: 10.1128/JVI.02278-13. [Epub ahead of print] PMID: 24522930Free PMC Article
Sadreameli SC, Reller ME, Bundy DG, Casella JF, Strouse JJ
Pediatr Blood Cancer 2014 May;61(5):875-8. Epub 2014 Jan 31 doi: 10.1002/pbc.24887. [Epub ahead of print] PMID: 24481883
Ning J
Trop Doct 2014 Apr;44(2):69-70. Epub 2014 Jan 10 doi: 10.1177/0049475513517230. [Epub ahead of print] PMID: 24414043
Chen Y, Zhang J, Qiao C, Wang J, Yang H, Chen H
Arch Virol 2014 Jun;159(6):1413-9. Epub 2014 Jan 3 doi: 10.1007/s00705-013-1955-5. [Epub ahead of print] PMID: 24385157
Kennedy ED, Roy M, Norris J, Fry AM, Kanzaria M, Blau DM, Shieh WJ, Zaki SR, Waller K, Kamimoto L, Finelli L, Jhung MA; 2009 Pandemic H1N1 Influenza-Associated Lower Respiratory Tract Hemorrhage Working Group
Influenza Other Respir Viruses 2013 Sep;7(5):761-5. Epub 2012 Dec 20 doi: 10.1111/irv.12026. [Epub ahead of print] PMID: 23279922

Therapy

Talaat KR, Luke CJ, Khurana S, Manischewitz J, King LR, McMahon BA, Karron RA, Lewis KD, Qin J, Follmann DA, Golding H, Neuzil KM, Subbarao K
J Infect Dis 2014 Jun 15;209(12):1860-9. Epub 2014 Mar 5 doi: 10.1093/infdis/jiu123. [Epub ahead of print] PMID: 24604819
Falsey AR, McElhaney JE, Beran J, van Essen GA, Duval X, Esen M, Galtier F, Gervais P, Hwang SJ, Kremsner P, Launay O, Leroux-Roels G, McNeil SA, Nowakowski A, Richardus JH, Ruiz-Palacios G, St Rose S, Devaster JM, Oostvogels L, Durviaux S, Taylor S
J Infect Dis 2014 Jun 15;209(12):1873-81. Epub 2014 Jan 29 doi: 10.1093/infdis/jit839. [Epub ahead of print] PMID: 24482398Free PMC Article
Ottóffy G, Horváth P, Muth L, Sólyom A, Garami M, Kovács G, Nyári T, Molnár D, Pauler G, Jankovics I
Pediatr Blood Cancer 2014 Jun;61(6):1013-6. Epub 2014 Jan 3 doi: 10.1002/pbc.24893. [Epub ahead of print] PMID: 24395342
Delgado-Rodríguez M, Castilla J, Godoy P, Martín V, Soldevila N, Alonso J, Astray J, Baricot M, Galán JC, Castro A, Gónzález-Candelas F, Mayoral JM, Quintana JM, Pumarola T, Tamames S, Sáez M, Domínguez A; CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain
Influenza Other Respir Viruses 2013 Nov;7(6):1336-42. Epub 2013 May 4 doi: 10.1111/irv.12119. [Epub ahead of print] PMID: 23647645
Kennedy ED, Roy M, Norris J, Fry AM, Kanzaria M, Blau DM, Shieh WJ, Zaki SR, Waller K, Kamimoto L, Finelli L, Jhung MA; 2009 Pandemic H1N1 Influenza-Associated Lower Respiratory Tract Hemorrhage Working Group
Influenza Other Respir Viruses 2013 Sep;7(5):761-5. Epub 2012 Dec 20 doi: 10.1111/irv.12026. [Epub ahead of print] PMID: 23279922

Prognosis

Patterson-Lomba O, Van Noort S, Cowling BJ, Wallinga J, Gomes MG, Lipsitch M, Goldstein E
Am J Epidemiol 2014 Jun 1;179(11):1394-401. Epub 2014 Apr 18 doi: 10.1093/aje/kwu061. [Epub ahead of print] PMID: 24748609Free PMC Article
Sadreameli SC, Reller ME, Bundy DG, Casella JF, Strouse JJ
Pediatr Blood Cancer 2014 May;61(5):875-8. Epub 2014 Jan 31 doi: 10.1002/pbc.24887. [Epub ahead of print] PMID: 24481883
Fowlkes A, Giorgi A, Erdman D, Temte J, Goodin K, Di Lonardo S, Sun Y, Martin K, Feist M, Linz R, Boulton R, Bancroft E, McHugh L, Lojo J, Filbert K, Finelli L; IISP Working Group
J Infect Dis 2014 Jun 1;209(11):1715-25. Epub 2013 Dec 12 doi: 10.1093/infdis/jit806. [Epub ahead of print] PMID: 24338352
Delgado-Rodríguez M, Castilla J, Godoy P, Martín V, Soldevila N, Alonso J, Astray J, Baricot M, Galán JC, Castro A, Gónzález-Candelas F, Mayoral JM, Quintana JM, Pumarola T, Tamames S, Sáez M, Domínguez A; CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain
Influenza Other Respir Viruses 2013 Nov;7(6):1336-42. Epub 2013 May 4 doi: 10.1111/irv.12119. [Epub ahead of print] PMID: 23647645
Kennedy ED, Roy M, Norris J, Fry AM, Kanzaria M, Blau DM, Shieh WJ, Zaki SR, Waller K, Kamimoto L, Finelli L, Jhung MA; 2009 Pandemic H1N1 Influenza-Associated Lower Respiratory Tract Hemorrhage Working Group
Influenza Other Respir Viruses 2013 Sep;7(5):761-5. Epub 2012 Dec 20 doi: 10.1111/irv.12026. [Epub ahead of print] PMID: 23279922

Clinical prediction guides

Talaat KR, Luke CJ, Khurana S, Manischewitz J, King LR, McMahon BA, Karron RA, Lewis KD, Qin J, Follmann DA, Golding H, Neuzil KM, Subbarao K
J Infect Dis 2014 Jun 15;209(12):1860-9. Epub 2014 Mar 5 doi: 10.1093/infdis/jiu123. [Epub ahead of print] PMID: 24604819
Vellozzi C, Iqbal S, Stewart B, Tokars J, DeStefano F
Am J Public Health 2014 Apr;104(4):696-701. Epub 2014 Feb 13 doi: 10.2105/AJPH.2013.301651. [Epub ahead of print] PMID: 24524517
Yang H, Chang JC, Guo Z, Carney PJ, Shore DA, Donis RO, Cox NJ, Villanueva JM, Klimov AI, Stevens J
J Virol 2014 May;88(9):4828-38. Epub 2014 Feb 12 doi: 10.1128/JVI.02278-13. [Epub ahead of print] PMID: 24522930Free PMC Article
Falsey AR, McElhaney JE, Beran J, van Essen GA, Duval X, Esen M, Galtier F, Gervais P, Hwang SJ, Kremsner P, Launay O, Leroux-Roels G, McNeil SA, Nowakowski A, Richardus JH, Ruiz-Palacios G, St Rose S, Devaster JM, Oostvogels L, Durviaux S, Taylor S
J Infect Dis 2014 Jun 15;209(12):1873-81. Epub 2014 Jan 29 doi: 10.1093/infdis/jit839. [Epub ahead of print] PMID: 24482398Free PMC Article
Fowlkes A, Dasgupta S, Chao E, Lemmings J, Goodin K, Harris M, Martin K, Feist M, Wu W, Boulton R, Temte J, Brammer L, Finelli L
Influenza Other Respir Viruses 2013 Sep;7(5):694-700. Epub 2012 Sep 18 doi: 10.1111/irv.12014. [Epub ahead of print] PMID: 22984820

Recent systematic reviews

Heneghan CJ, Onakpoya I, Thompson M, Spencer EA, Jones M, Jefferson T
BMJ 2014 Apr 9;348:g2547. PMID: 24811412Free PMC Article
Wong VW, Cowling BJ, Aiello AE
Epidemiol Infect 2014 May;142(5):922-32. Epub 2014 Jan 24 doi: 10.1017/S095026881400003X. [Epub ahead of print] PMID: 24572643
Beck CR, McKenzie BC, Hashim AB, Harris RC, Zanuzdana A, Agboado G, Orton E, Béchard-Evans L, Morgan G, Stevenson C, Weston R, Mukaigawara M, Enstone J, Augustine G, Butt M, Kim S, Puleston R, Dabke G, Howard R, O'Boyle J, O'Brien M, Ahyow L, Denness H, Farmer S, Figureroa J, Fisher P, Greaves F, Haroon M, Haroon S, Hird C, Isba R, Ishola DA, Kerac M, Parish V, Roberts J, Rosser J, Theaker S, Wallace D, Wigglesworth N, Lingard L, Vinogradova Y, Horiuchi H, Peñalver J, Nguyen-Van-Tam JS
Influenza Other Respir Viruses 2013 Sep;7 Suppl 2:72-5. doi: 10.1111/irv.12084. PMID: 24034488
Kayali G, Webby RJ, Samhouri D, Mafi AR, Bassili A
Influenza Other Respir Viruses 2013 Nov;7(6):914-21. Epub 2013 Jun 30 doi: 10.1111/irv.12136. [Epub ahead of print] PMID: 23809648
Savy V, Ciapponi A, Bardach A, Glujovsky D, Aruj P, Mazzoni A, Gibbons L, Ortega-Barría E, Colindres RE
Influenza Other Respir Viruses 2013 Nov;7(6):1017-32. Epub 2012 Dec 5 doi: 10.1111/irv.12036. [Epub ahead of print] PMID: 23210504

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