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Results: 4

1.

sorafenib

A synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. [from NCI]

MedGen UID:
273831
Concept ID:
C1516119
Pharmacologic Substance
2.

Acute leukemia

MedGen UID:
505251
Concept ID:
CN002259
Finding
3.

Acute

Symptoms or signs that begin and worsen quickly; not chronic. [from NCI]

MedGen UID:
61381
Concept ID:
C0205178
4.

FLT3 Internal Tandem Duplication

A genetic abnormality that arises from duplications of the juxtamembrane portion of the gene and results in constitutive activation of the FLT3 receptor tyrosine kinase protein in early hematopoietic progenitor cells. It is associated with acute myelogenous leukemia where it appears to correlate with a poor prognosis. [from NCI]

MedGen UID:
385038
Concept ID:
C2348499
Cell or Molecular Dysfunction

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