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Results: 1 to 20 of 24

1.

Clinical Significance

A finding that has treatment or management implications for a patient's condition. [from NCI]

MedGen UID:
417419
Concept ID:
C2826293
Finding
2.

Atazanavir

A synthetic antiviral agent. As a symmetric azapeptide agent structurally different from other HIV protease inhibitors, atazanavir selectively binds to and inhibits human immunodeficiency virus (HIV) protease, thereby preventing cleavage of the gag-pol viral polyprotein and resulting in the release of immature, noninfectious virions. This agent does not elevate serum lipids, a common problem with other protease inhibitors. (NCI04) [from NCI]

MedGen UID:
218840
Concept ID:
C1145759
Pharmacologic Substance
3.

emtricitabine

A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group). [from NCI]

MedGen UID:
178568
Concept ID:
C0909839
Pharmacologic Substance
4.

lopinavir

An antiretroviral drug of the protease inhibitor class used as a fixed-dose combination with RITONAVIR. [from MeSH]

MedGen UID:
145897
Concept ID:
C0674432
Pharmacologic Substance
5.

Ritonavir

An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. [from MeSH]

MedGen UID:
132886
Concept ID:
C0292818
Pharmacologic Substance
6.

Tenofovir

A synthetic antiviral acyclic nucleotide analogue of adenosine 5-monophosphate. Tenofovir is incorporated into human immunodeficiency viral DNA instead of the natural substrate deoxyadenosine 5-triphosphate, thereby inhibiting HIV-1 reverse transcriptase (RT), an RNA-dependent DNA polymerase, and resulting in DNA chain termination and impairment of viral replication and propagation. This agent prevents HIV from reproducing in uninfected cells only. Tenofovir exhibits activity against the hepatitis B virus (HBV). (NCI04) [from NCI]

MedGen UID:
94499
Concept ID:
C0384228
Pharmacologic Substance
7.

Viral Load result

The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression. [from MeSH]

MedGen UID:
84035
Concept ID:
C0376705
Finding
8.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
9.

Lopinavir+ritonavir

A combination of the drugs ritonavir and lopinavir. It is used to treat infection with HIV (the virus that causes AIDS). It is also being studied in the treatment of some types of cancer. Lopinavir/ritonavir blocks the ability of HIV to make copies of itself and may help other anticancer drugs work better or may block the growth of cancer cells. Ritonavir blocks the breakdown of lopinavir. Lopinavir/ritonavir is a type of anti-HIV agent and a type of protease inhibitor. [from NCI]

MedGen UID:
215250
Concept ID:
C0939237
Pharmacologic Substance
10.

Viral disease

Viruses are capsules with genetic material inside. They are very tiny, much smaller than bacteria. Viruses cause familiar infectious diseases such as the common cold, flu and warts. They also cause severe illnesses such as HIV/AIDS, smallpox and hemorrhagic fevers. . Viruses are like hijackers. They invade living, normal cells and use those cells to multiply and produce other viruses like themselves. This eventually kills the cells, which can make you sick. Viral infections are hard to treat because viruses live inside your body's cells. They are protected from medicines, which usually move through your bloodstream. Antibiotics do not work for viral infections. There are a few antiviral medicines available. Vaccines can help prevent you from getting many viral diseases. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

MedGen UID:
53027
Concept ID:
C0042769
Disease or Syndrome
11.

Sexually Transmitted Diseases, Viral

Viral diseases which are transmitted or propagated by sexual conduct. [from MeSH]

MedGen UID:
48646
Concept ID:
C0036918
Disease or Syndrome
12.

Disease due to Retroviridae

Virus diseases caused by the RETROVIRIDAE. [from MeSH]

MedGen UID:
48440
Concept ID:
C0035369
Disease or Syndrome
13.

Disease due to Lentivirus

Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection. [from MeSH]

MedGen UID:
38233
Concept ID:
C0079680
Disease or Syndrome
14.

Sexually transmitted infectious disease

Sexually transmitted diseases (STDs) are infections that you can get from having sex with someone who has the infection. The causes of STDs are bacteria, parasites and viruses. There are more than 20 types of STDs, including : -Chlamydia. -Gonorrhea. -Genital herpes. -HIV/AIDS . -HPV. -Syphilis. -Trichomoniasis. Most STDs affect both men and women, but in many cases the health problems they cause can be more severe for women. If a pregnant woman has an STD, it can cause serious health problems for the baby. If you have an STD caused by bacteria or parasites, your health care provider can treat it with antibiotics or other medicines. If you have an STD caused by a virus, there is no cure. Sometimes medicines can keep the disease under control. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading STDs. Centers for Disease Control and Prevention.  [from MedlinePlus]

MedGen UID:
11402
Concept ID:
C0036916
Disease or Syndrome
15.

RNA Virus Infections

MedGen UID:
11250
Concept ID:
C0035690
Disease or Syndrome
16.

Immunodeficiency disorder

Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral. [from MeSH]

MedGen UID:
7034
Concept ID:
C0021051
Disease or Syndrome
17.

Disorder of immune system

Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these foreign invaders. Then its job is to keep them out, or if it can't, to find and destroy them. If your immune system cannot do its job, the results can be serious. Disorders of the immune system include: -Allergy and asthma - immune responses to substances that are usually not harmful. -Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts. -Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

MedGen UID:
5759
Concept ID:
C0021053
Disease or Syndrome
18.

Human immunodeficiency virus infection

An infection caused by the human immunodeficiency virus. [from NCI]

MedGen UID:
5583
Concept ID:
C0019693
Disease or Syndrome
19.

Reyataz

MedGen UID:
263524
Concept ID:
C1258207
Pharmacologic Substance
20.

BMS-232632-05

MedGen UID:
258477
Concept ID:
C1174044
Pharmacologic Substance

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