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Serine/Threonine Kinase Inhibitor

MedGen UID:
407971
Concept ID:
C1883005
Pharmacologic Substance
Synonyms: Serine Threonine Kinase Inhibitor
 

Definition

Any substance that inhibits serine/threonine protein kinase, an enzyme that phosphorylates the hydroxyl group of serine or threonine on various proteins in various signaling cascades. Inhibition of serine/threonine protein kinase can inhibit cell proliferation and induce apoptosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGSerine/Threonine Kinase Inhibitor

Recent clinical studies

Etiology

Vergote IB, Chekerov R, Amant F, Harter P, Casado A, Emerich J, Bauknecht T, Mansouri K, Myrand SP, Nguyen TS, Shi P, Sehouli J
J Clin Oncol 2013 Sep 1;31(25):3127-32. Epub 2013 Jul 29 doi: 10.1200/JCO.2012.44.9116. [Epub ahead of print] PMID: 23897968
Clément-Duchêne C, Natale RB, Jahan T, Krupitskaya Y, Osarogiagbon R, Sanborn RE, Bernstein ED, Dudek AZ, Latz JE, Shi P, Wakelee HA
Lung Cancer 2012 Oct;78(1):57-62. Epub 2012 Jul 17 doi: 10.1016/j.lungcan.2012.06.003. [Epub ahead of print] PMID: 22809813
Dreicer R, Garcia J, Hussain M, Rini B, Vogelzang N, Srinivas S, Somer B, Zhao YD, Kania M, Raghavan D
Invest New Drugs 2011 Dec;29(6):1441-8. Epub 2010 Apr 6 doi: 10.1007/s10637-010-9428-0. [Epub ahead of print] PMID: 20369375
Oh Y, Herbst RS, Burris H, Cleverly A, Musib L, Lahn M, Bepler G
J Clin Oncol 2008 Mar 1;26(7):1135-41. doi: 10.1200/JCO.2007.14.3685. PMID: 18309949
Sato T, Asamitsu K, Yang JP, Takahashi N, Tetsuka T, Yoneyama A, Kanagawa A, Okamoto T
AIDS Res Hum Retroviruses 1998 Mar 1;14(4):293-8. PMID: 9519889

Diagnosis

Vergote IB, Chekerov R, Amant F, Harter P, Casado A, Emerich J, Bauknecht T, Mansouri K, Myrand SP, Nguyen TS, Shi P, Sehouli J
J Clin Oncol 2013 Sep 1;31(25):3127-32. Epub 2013 Jul 29 doi: 10.1200/JCO.2012.44.9116. [Epub ahead of print] PMID: 23897968
Oh Y, Herbst RS, Burris H, Cleverly A, Musib L, Lahn M, Bepler G
J Clin Oncol 2008 Mar 1;26(7):1135-41. doi: 10.1200/JCO.2007.14.3685. PMID: 18309949
Hanauske AR, Eismann U, Oberschmidt O, Pospisil H, Hanauske-Abel HM, Blatter J, Ma D, Chen V, Lahn M
Invest New Drugs 2008 Jun;26(3):215-22. Epub 2007 Nov 14 doi: 10.1007/s10637-007-9095-y. [Epub ahead of print] PMID: 18000644
Crepaldi L, Silveri L, Calzetti F, Pinardi C, Cassatella MA
Int Immunol 2002 Oct;14(10):1145-53. PMID: 12356680
Symes A, Gearan T, Eby J, Fink JS
J Biol Chem 1997 Apr 11;272(15):9648-54. PMID: 9092493

Therapy

Jourdan E, Leblond V, Maisonneuve H, Benhadji KA, Hossain AM, Nguyen TS, Wooldridge JE, Moreau P
Leuk Lymphoma 2014 Sep;55(9):2013-7. Epub 2014 May 2 doi: 10.3109/10428194.2013.861066. [Epub ahead of print] PMID: 24180331
Vergote IB, Chekerov R, Amant F, Harter P, Casado A, Emerich J, Bauknecht T, Mansouri K, Myrand SP, Nguyen TS, Shi P, Sehouli J
J Clin Oncol 2013 Sep 1;31(25):3127-32. Epub 2013 Jul 29 doi: 10.1200/JCO.2012.44.9116. [Epub ahead of print] PMID: 23897968
Dreicer R, Garcia J, Rini B, Vogelzang N, Srinivas S, Somer B, Shi P, Kania M, Raghavan D
Invest New Drugs 2013 Aug;31(4):1044-50. Epub 2013 Feb 24 doi: 10.1007/s10637-013-9940-0. [Epub ahead of print] PMID: 23435622
Clément-Duchêne C, Natale RB, Jahan T, Krupitskaya Y, Osarogiagbon R, Sanborn RE, Bernstein ED, Dudek AZ, Latz JE, Shi P, Wakelee HA
Lung Cancer 2012 Oct;78(1):57-62. Epub 2012 Jul 17 doi: 10.1016/j.lungcan.2012.06.003. [Epub ahead of print] PMID: 22809813
Oh Y, Herbst RS, Burris H, Cleverly A, Musib L, Lahn M, Bepler G
J Clin Oncol 2008 Mar 1;26(7):1135-41. doi: 10.1200/JCO.2007.14.3685. PMID: 18309949

Prognosis

Tanai C, Yamamoto N, Ohe Y, Takahashi T, Kunitoh H, Murakami H, Yamamoto N, Nakamura Y, Nokihara H, Shukuya T, Baldwin JR, Koshiji M, Tamura T
J Thorac Oncol 2010 Jul;5(7):1068-74. doi: 10.1097/JTO.0b013e3181da3899. PMID: 20453691
Spindler KL, Lindebjerg J, Lahn M, Kjaer-Frifeldt S, Jakobsen A
Int J Colorectal Dis 2009 Jun;24(6):641-5. Epub 2009 Mar 10 doi: 10.1007/s00384-009-0680-8. [Epub ahead of print] PMID: 19277684
Oh Y, Herbst RS, Burris H, Cleverly A, Musib L, Lahn M, Bepler G
J Clin Oncol 2008 Mar 1;26(7):1135-41. doi: 10.1200/JCO.2007.14.3685. PMID: 18309949
Hanauske AR, Eismann U, Oberschmidt O, Pospisil H, Hanauske-Abel HM, Blatter J, Ma D, Chen V, Lahn M
Invest New Drugs 2008 Jun;26(3):215-22. Epub 2007 Nov 14 doi: 10.1007/s10637-007-9095-y. [Epub ahead of print] PMID: 18000644
Morschhauser F, Seymour JF, Kluin-Nelemans HC, Grigg A, Wolf M, Pfreundschuh M, Tilly H, Raemaekers J, van 't Veer MB, Milpied N, Cartron G, Pezzutto A, Spencer A, Reyes F, Dreyling M
Ann Oncol 2008 Feb;19(2):247-53. Epub 2007 Sep 28 doi: 10.1093/annonc/mdm463. [Epub ahead of print] PMID: 17906297

Clinical prediction guides

Jourdan E, Leblond V, Maisonneuve H, Benhadji KA, Hossain AM, Nguyen TS, Wooldridge JE, Moreau P
Leuk Lymphoma 2014 Sep;55(9):2013-7. Epub 2014 May 2 doi: 10.3109/10428194.2013.861066. [Epub ahead of print] PMID: 24180331
Ghobrial IM, Moreau P, Harris B, Poon T, Jourdan E, Maisonneuve H, Benhadji KA, Hossain AM, Nguyen TS, Wooldridge JE, Leblond V
Clin Cancer Res 2012 Sep 15;18(18):5043-50. Epub 2012 Aug 9 doi: 10.1158/1078-0432.CCR-12-0181. [Epub ahead of print] PMID: 22879385
Jemaà M, Vitale I, Kepp O, Berardinelli F, Galluzzi L, Senovilla L, Mariño G, Malik SA, Rello-Varona S, Lissa D, Antoccia A, Tailler M, Schlemmer F, Harper F, Pierron G, Castedo M, Kroemer G
EMBO Mol Med 2012 Jun;4(6):500-14. Epub 2012 Mar 21 doi: 10.1002/emmm.201200228. [Epub ahead of print] PMID: 22438244Free PMC Article
Dreicer R, Garcia J, Hussain M, Rini B, Vogelzang N, Srinivas S, Somer B, Zhao YD, Kania M, Raghavan D
Invest New Drugs 2011 Dec;29(6):1441-8. Epub 2010 Apr 6 doi: 10.1007/s10637-010-9428-0. [Epub ahead of print] PMID: 20369375
Oh Y, Herbst RS, Burris H, Cleverly A, Musib L, Lahn M, Bepler G
J Clin Oncol 2008 Mar 1;26(7):1135-41. doi: 10.1200/JCO.2007.14.3685. PMID: 18309949

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