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Tuberculosis

MedGen UID:
22513
Concept ID:
C0041296
Disease or Syndrome
Synonyms: Disease, Koch's; Disease, Kochs; Koch Disease; Koch's Disease; Kochs Disease; Tuberculoses
SNOMED CT: Tuberculous (371569005); Infection due to Mycobacterium tuberculosis (373576009); TB - Tuberculosis (56717001); Tuberculosis (56717001)
 

Definition

Tuberculosis (TB) is a bacterial infection caused by a germ called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but they can also damage other parts of the body. TB spreads through the air when a person with TB of the lungs or throat coughs, sneezes or talks. If you have been exposed, you should go to your doctor for tests. You are more likely to get TB if you have a weak immune system. . Symptoms of TB in the lungs may include: - A bad cough that lasts 3 weeks or longer . - Weight loss. - Coughing up blood or mucus. - Weakness or fatigue . - Fever and chills. - Night sweats . If not treated properly, TB can be deadly. You can usually cure active TB by taking several medicines for a long period of time. People with latent TB can take medicine so that they do not develop active TB. Centers for Disease Control and Prevention.  [from MedlinePlus]

Recent clinical studies

Etiology

Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS, Hibberd ML, Kern F, Langford PR, Ling L, Mlotha R, Ottenhoff TH, Pienaar S, Pillay V, Scott JA, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley B; ILULU Consortium; KIDS TB Study Group
N Engl J Med 2014 May 1;370(18):1712-23. doi: 10.1056/NEJMoa1303657. PMID: 24785206Free PMC Article
Tientcheu LD, Sutherland JS, de Jong BC, Kampmann B, Jafali J, Adetifa IM, Antonio M, Dockrell HM, Ota MO
Eur J Immunol 2014 May;44(5):1387-98. Epub 2014 Feb 20 doi: 10.1002/eji.201343956. [Epub ahead of print] PMID: 24481948
Harris SA, Meyer J, Satti I, Marsay L, Poulton ID, Tanner R, Minassian AM, Fletcher HA, McShane H
J Infect Dis 2014 Apr 15;209(8):1259-68. Epub 2013 Nov 23 doi: 10.1093/infdis/jit647. [Epub ahead of print] PMID: 24273174Free PMC Article
Parihar SP, Guler R, Khutlang R, Lang DM, Hurdayal R, Mhlanga MM, Suzuki H, Marais AD, Brombacher F
J Infect Dis 2014 Mar 1;209(5):754-63. Epub 2013 Oct 16 doi: 10.1093/infdis/jit550. [Epub ahead of print] PMID: 24133190
Naranbhai V, Hill AV, Abdool Karim SS, Naidoo K, Abdool Karim Q, Warimwe GM, McShane H, Fletcher H
J Infect Dis 2014 Feb 15;209(4):500-9. Epub 2013 Sep 16 doi: 10.1093/infdis/jit494. [Epub ahead of print] PMID: 24041796Free PMC Article

Diagnosis

Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS, Hibberd ML, Kern F, Langford PR, Ling L, Mlotha R, Ottenhoff TH, Pienaar S, Pillay V, Scott JA, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley B; ILULU Consortium; KIDS TB Study Group
N Engl J Med 2014 May 1;370(18):1712-23. doi: 10.1056/NEJMoa1303657. PMID: 24785206Free PMC Article
Weiner J 3rd, Kaufmann SH
J Intern Med 2014 May;275(5):467-80. doi: 10.1111/joim.12212. PMID: 24635488
Theron G, Peter J, Dowdy D, Langley I, Squire SB, Dheda K
Lancet Infect Dis 2014 Jun;14(6):527-32. Epub 2014 Jan 15 doi: 10.1016/S1473-3099(13)70360-8. [Epub ahead of print] PMID: 24438820
Naranbhai V, Hill AV, Abdool Karim SS, Naidoo K, Abdool Karim Q, Warimwe GM, McShane H, Fletcher H
J Infect Dis 2014 Feb 15;209(4):500-9. Epub 2013 Sep 16 doi: 10.1093/infdis/jit494. [Epub ahead of print] PMID: 24041796Free PMC Article
Harapan H, Fitra F, Ichsan I, Mulyadi M, Miotto P, Hasan NA, Calado M, Cirillo DM
Tuberculosis (Edinb) 2013 Nov;93(6):596-605. Epub 2013 Aug 15 doi: 10.1016/j.tube.2013.08.004. [Epub ahead of print] PMID: 24025365

Therapy

Tientcheu LD, Sutherland JS, de Jong BC, Kampmann B, Jafali J, Adetifa IM, Antonio M, Dockrell HM, Ota MO
Eur J Immunol 2014 May;44(5):1387-98. Epub 2014 Feb 20 doi: 10.1002/eji.201343956. [Epub ahead of print] PMID: 24481948
Theron G, Peter J, Dowdy D, Langley I, Squire SB, Dheda K
Lancet Infect Dis 2014 Jun;14(6):527-32. Epub 2014 Jan 15 doi: 10.1016/S1473-3099(13)70360-8. [Epub ahead of print] PMID: 24438820
Harris SA, Meyer J, Satti I, Marsay L, Poulton ID, Tanner R, Minassian AM, Fletcher HA, McShane H
J Infect Dis 2014 Apr 15;209(8):1259-68. Epub 2013 Nov 23 doi: 10.1093/infdis/jit647. [Epub ahead of print] PMID: 24273174Free PMC Article
Parihar SP, Guler R, Khutlang R, Lang DM, Hurdayal R, Mhlanga MM, Suzuki H, Marais AD, Brombacher F
J Infect Dis 2014 Mar 1;209(5):754-63. Epub 2013 Oct 16 doi: 10.1093/infdis/jit550. [Epub ahead of print] PMID: 24133190
Naranbhai V, Hill AV, Abdool Karim SS, Naidoo K, Abdool Karim Q, Warimwe GM, McShane H, Fletcher H
J Infect Dis 2014 Feb 15;209(4):500-9. Epub 2013 Sep 16 doi: 10.1093/infdis/jit494. [Epub ahead of print] PMID: 24041796Free PMC Article

Prognosis

Agrawal R, Saini DK
Biochem Biophys Res Commun 2014 Apr 18;446(4):1172-8. Epub 2014 Mar 22 doi: 10.1016/j.bbrc.2014.03.066. [Epub ahead of print] PMID: 24667597
Churchyard GJ, Fielding KL, Lewis JJ, Coetzee L, Corbett EL, Godfrey-Faussett P, Hayes RJ, Chaisson RE, Grant AD; Thibela TB Study Team
N Engl J Med 2014 Jan 23;370(4):301-10. doi: 10.1056/NEJMoa1214289. PMID: 24450889
Naranbhai V, Hill AV, Abdool Karim SS, Naidoo K, Abdool Karim Q, Warimwe GM, McShane H, Fletcher H
J Infect Dis 2014 Feb 15;209(4):500-9. Epub 2013 Sep 16 doi: 10.1093/infdis/jit494. [Epub ahead of print] PMID: 24041796Free PMC Article
Harapan H, Fitra F, Ichsan I, Mulyadi M, Miotto P, Hasan NA, Calado M, Cirillo DM
Tuberculosis (Edinb) 2013 Nov;93(6):596-605. Epub 2013 Aug 15 doi: 10.1016/j.tube.2013.08.004. [Epub ahead of print] PMID: 24025365
Khurshid S, Khalid R, Afzal M, Waheed Akhtar M
Tuberculosis (Edinb) 2013 Nov;93(6):654-9. Epub 2013 Aug 11 doi: 10.1016/j.tube.2013.07.005. [Epub ahead of print] PMID: 23978525

Clinical prediction guides

Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS, Hibberd ML, Kern F, Langford PR, Ling L, Mlotha R, Ottenhoff TH, Pienaar S, Pillay V, Scott JA, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley B; ILULU Consortium; KIDS TB Study Group
N Engl J Med 2014 May 1;370(18):1712-23. doi: 10.1056/NEJMoa1303657. PMID: 24785206Free PMC Article
Reba SM, Li Q, Onwuzulike S, Ding X, Karim AF, Hernandez Y, Fulton SA, Harding CV, Lancioni CL, Nagy N, Rodriguez ME, Wearsch PA, Rojas RE
Eur J Immunol 2014 May;44(5):1410-21. Epub 2014 Mar 14 doi: 10.1002/eji.201344100. [Epub ahead of print] PMID: 24497180
Naranbhai V, Hill AV, Abdool Karim SS, Naidoo K, Abdool Karim Q, Warimwe GM, McShane H, Fletcher H
J Infect Dis 2014 Feb 15;209(4):500-9. Epub 2013 Sep 16 doi: 10.1093/infdis/jit494. [Epub ahead of print] PMID: 24041796Free PMC Article
Harapan H, Fitra F, Ichsan I, Mulyadi M, Miotto P, Hasan NA, Calado M, Cirillo DM
Tuberculosis (Edinb) 2013 Nov;93(6):596-605. Epub 2013 Aug 15 doi: 10.1016/j.tube.2013.08.004. [Epub ahead of print] PMID: 24025365
Khurshid S, Khalid R, Afzal M, Waheed Akhtar M
Tuberculosis (Edinb) 2013 Nov;93(6):654-9. Epub 2013 Aug 11 doi: 10.1016/j.tube.2013.07.005. [Epub ahead of print] PMID: 23978525

Recent systematic reviews

Reves R, Schluger NW
Am J Respir Crit Care Med 2014 Apr 15;189(8):894-8. doi: 10.1164/rccm.201402-0210UP. PMID: 24735031
Jiang D, Zhang Q, Zheng Q, Zhou H, Jin J, Zhou W, Bartlam M, Rao Z
FEBS J 2014 Jan;281(1):331-41. Epub 2013 Dec 2 doi: 10.1111/febs.12600. [Epub ahead of print] PMID: 24299297
Soares P, Alves RJ, Abecasis AB, Penha-Gonçalves C, Gomes MG, Pereira-Leal JB
BMC Bioinformatics 2013 Aug 30;14:264. doi: 10.1186/1471-2105-14-264. [Epub ahead of print] PMID: 24001185Free PMC Article
Yin X, Zheng L, Lin L, Hu Y, Zheng F, Hu Y, Wang Q
J Infect 2013 Nov;67(5):369-77. Epub 2013 Jun 22 doi: 10.1016/j.jinf.2013.06.009. [Epub ahead of print] PMID: 23796870
Pasipanodya JG, Gumbo T
Clin Infect Dis 2013 Jul;57(1):21-31. Epub 2013 Mar 13 doi: 10.1093/cid/cit167. [Epub ahead of print] PMID: 23487389Free PMC Article

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