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varenicline

MedGen UID:
292288
Concept ID:
C1569608
Pharmacologic Substance
Synonyms: 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)benzazepine
SNOMED CT: Varenicline (421772003); Varenicline (420507002)
 

Definition

A drug used to help people stop smoking by acting the same way nicotine acts in the brain. It is a type of nicotine receptor partial agonist. [from NCI_NCI-GLOSS]

Term Hierarchy

Recent clinical studies

Etiology

Koegelenberg CF, Noor F, Bateman ED, van Zyl-Smit RN, Bruning A, O'Brien JA, Smith C, Abdool-Gaffar MS, Emanuel S, Esterhuizen TM, Irusen EM
JAMA 2014 Jul;312(2):155-61. doi: 10.1001/jama.2014.7195. PMID: 25005652
Gonzales D, Hajek P, Pliamm L, Nackaerts K, Tseng LJ, McRae TD, Treadow J
Clin Pharmacol Ther 2014 Sep;96(3):390-6. Epub 2014 Jun 9 doi: 10.1038/clpt.2014.124. [Epub ahead of print] PMID: 24911368Free PMC Article
Suehs BT, Davis C, Galaznik A, Joshi AV, Zou KH, Patel NC
J Manag Care Spec Pharm 2014 Jun;20(6):592-600. PMID: 24856597
Hsueh KC, Hsueh SC, Chou MY, Pan LF, Tu MS, McEwen A, West R
Psychopharmacology (Berl) 2014 Jul;231(14):2819-23. Epub 2014 Feb 13 doi: 10.1007/s00213-014-3482-9. [Epub ahead of print] PMID: 24522334
Plebani JG, Lynch KG, Rennert L, Pettinati HM, O'Brien CP, Kampman KM
Drug Alcohol Depend 2013 Dec 1;133(2):754-8. Epub 2013 Jul 31 doi: 10.1016/j.drugalcdep.2013.06.019. [Epub ahead of print] PMID: 23916324Free PMC Article

Diagnosis

Leaviss J, Sullivan W, Ren S, Everson-Hock E, Stevenson M, Stevens JW, Strong M, Cantrell A
Health Technol Assess 2014 May;18(33):1-120. doi: 10.3310/hta18330. PMID: 24831822
Evins AE, Cather C, Pratt SA, Pachas GN, Hoeppner SS, Goff DC, Achtyes ED, Ayer D, Schoenfeld DA
JAMA 2014 Jan 8;311(2):145-54. doi: 10.1001/jama.2013.285113. PMID: 24399553Free PMC Article
Verrico CD, Mahoney JJ 3rd, Thompson-Lake DG, Bennett RS, Newton TF, De La Garza R 2nd
Int J Neuropsychopharmacol 2014 Feb;17(2):223-33. doi: 10.1017/S146114571300134X. PMID: 24393456
Gibbons RD, Mann JJ
Am J Psychiatry 2013 Dec;170(12):1460-7. doi: 10.1176/appi.ajp.2013.12121599. PMID: 24030388Free PMC Article
Harrison-Woolrych M, Paterson H, Tan M
Pharmacoepidemiol Drug Saf 2013 Oct;22(10):1086-92. Epub 2013 Aug 8 doi: 10.1002/pds.3489. [Epub ahead of print] PMID: 23926076

Therapy

Erwin BL, Slaton RM
Ann Pharmacother 2014 Nov;48(11):1445-55. Epub 2014 Aug 5 doi: 10.1177/1060028014545806. [Epub ahead of print] PMID: 25095786
Chengappa KN, Perkins KA, Brar JS, Schlicht PJ, Turkin SR, Hetrick ML, Levine MD, George TP
J Clin Psychiatry 2014 Jul;75(7):765-72. doi: 10.4088/JCP.13m08756. PMID: 25006684
Koegelenberg CF, Noor F, Bateman ED, van Zyl-Smit RN, Bruning A, O'Brien JA, Smith C, Abdool-Gaffar MS, Emanuel S, Esterhuizen TM, Irusen EM
JAMA 2014 Jul;312(2):155-61. doi: 10.1001/jama.2014.7195. PMID: 25005652
Gonzales D, Hajek P, Pliamm L, Nackaerts K, Tseng LJ, McRae TD, Treadow J
Clin Pharmacol Ther 2014 Sep;96(3):390-6. Epub 2014 Jun 9 doi: 10.1038/clpt.2014.124. [Epub ahead of print] PMID: 24911368Free PMC Article
Suehs BT, Davis C, Galaznik A, Joshi AV, Zou KH, Patel NC
J Manag Care Spec Pharm 2014 Jun;20(6):592-600. PMID: 24856597

Prognosis

Hsueh KC, Hsueh SC, Chou MY, Pan LF, Tu MS, McEwen A, West R
Psychopharmacology (Berl) 2014 Jul;231(14):2819-23. Epub 2014 Feb 13 doi: 10.1007/s00213-014-3482-9. [Epub ahead of print] PMID: 24522334
Evins AE, Cather C, Pratt SA, Pachas GN, Hoeppner SS, Goff DC, Achtyes ED, Ayer D, Schoenfeld DA
JAMA 2014 Jan 8;311(2):145-54. doi: 10.1001/jama.2013.285113. PMID: 24399553Free PMC Article
Cobb NK, Mays D, Graham AL
J Natl Cancer Inst Monogr 2013 Dec;2013(47):224-30. doi: 10.1093/jncimonographs/lgt020. PMID: 24395996
Harrison-Woolrych M, Paterson H, Tan M
Pharmacoepidemiol Drug Saf 2013 Oct;22(10):1086-92. Epub 2013 Aug 8 doi: 10.1002/pds.3489. [Epub ahead of print] PMID: 23926076
Nahvi S, Wu B, Richter KP, Bernstein SL, Arnsten JH
Drug Alcohol Depend 2013 Sep 1;132(1-2):47-52. Epub 2013 Jan 17 doi: 10.1016/j.drugalcdep.2012.12.026. [Epub ahead of print] PMID: 23332438Free PMC Article

Clinical prediction guides

Chengappa KN, Perkins KA, Brar JS, Schlicht PJ, Turkin SR, Hetrick ML, Levine MD, George TP
J Clin Psychiatry 2014 Jul;75(7):765-72. doi: 10.4088/JCP.13m08756. PMID: 25006684
Haber SL, Boomershine V, Raney E
J Pharm Pract 2014 Feb;27(1):65-70. Epub 2013 Sep 30 doi: 10.1177/0897190013504961. [Epub ahead of print] PMID: 24080536
Mocking RJ, Wever SA, Pflanz CP, Pringle A, Parsons E, McTavish SF, Cowen PJ, Harmer CJ, Schene AH
Psychopharmacology (Berl) 2014 Jan;231(1):143-8. Epub 2013 Jul 28 doi: 10.1007/s00213-013-3213-7. [Epub ahead of print] PMID: 23892777
Cobb NK, Mays D, Graham AL
J Natl Cancer Inst Monogr 2013 Dec;2013(47):224-30. doi: 10.1093/jncimonographs/lgt020. PMID: 24395996
Harrison-Woolrych M, Paterson H, Tan M
Pharmacoepidemiol Drug Saf 2013 Oct;22(10):1086-92. Epub 2013 Aug 8 doi: 10.1002/pds.3489. [Epub ahead of print] PMID: 23926076

Recent systematic reviews

Erwin BL, Slaton RM
Ann Pharmacother 2014 Nov;48(11):1445-55. Epub 2014 Aug 5 doi: 10.1177/1060028014545806. [Epub ahead of print] PMID: 25095786
Leaviss J, Sullivan W, Ren S, Everson-Hock E, Stevenson M, Stevens JW, Strong M, Cantrell A
Health Technol Assess 2014 May;18(33):1-120. doi: 10.3310/hta18330. PMID: 24831822
Nocente R, Vitali M, Balducci G, Enea D, Kranzler HR, Ceccanti M
Am J Addict 2013 Sep-Oct;22(5):453-9. Epub 2013 May 15 doi: 10.1111/j.1521-0391.2013.12037.x. [Epub ahead of print] PMID: 23952890
Ware JH, Vetrovec GW, Miller AB, Van Tosh A, Gaffney M, Yunis C, Arteaga C, Borer JS
Am J Ther 2013 May-Jun;20(3):235-46. doi: 10.1097/MJT.0b013e31828d455b. PMID: 23615317
Ahmed AI, Ali AN, Kramers C, Härmark LV, Burger DM, Verhoeven WM
J Clin Psychopharmacol 2013 Feb;33(1):55-62. doi: 10.1097/JCP.0b013e31827c0117. PMID: 23277249

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