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palivizumab

MedGen UID:
151303
Concept ID:
C0672596
Pharmacologic Substance
Synonyms: PALIVIZUMAB; Palivizumab
SNOMED CT: Palivizumab (386900007); Palivizumab (108725001)
 

Definition

A humanized monoclonal antibody against the fusion protein (F protein) of human respiratory syncytial virus (RSV), with prophylactic application in respiratory syncytial virus infections. RSV F protein, a small envelop glycoprotein, is not only required for cytopathic syncytia resulting from cell-to-cell fusion, but is also necessary for viral spreading and evading neutralizing antibody. Palivizumab neutralizes and inhibits fusion activity of RSV, thereby preventing syncytia formation. Administration of this antibody does not interfere with other immunizations. [from NCI]

Recent clinical studies

Etiology

Yoshihara S, Kusuda S, Mochizuki H, Okada K, Nishima S, Simões EA; C-CREW Investigators
Pediatrics 2013 Nov;132(5):811-8. Epub 2013 Oct 14 doi: 10.1542/peds.2013-0982. [Epub ahead of print] PMID: 24127479
Ohler KH, Pham JT
Am J Health Syst Pharm 2013 Aug 1;70(15):1342-6. doi: 10.2146/ajhp120526. PMID: 23867491
Robinson KA, Odelola OA, Saldanha IJ, McKoy NA
Cochrane Database Syst Rev 2013 Jun 5;6:CD007743. doi: 10.1002/14651858.CD007743.pub4. PMID: 23737087
La Via WV, Notario GF, Yu XQ, Sharma S, Noertersheuser PA, Robbie GJ
Pulm Pharmacol Ther 2013 Dec;26(6):666-71. Epub 2013 Mar 19 doi: 10.1016/j.pupt.2013.03.007. [Epub ahead of print] PMID: 23523663
Lundeen K, Pfeiffenberger T, Jacobson Vann J, O'Brien T, Sampson C, Wegner S
J Manag Care Pharm 2013 Mar;19(2):115-24. PMID: 23461427

Diagnosis

Yoshihara S, Kusuda S, Mochizuki H, Okada K, Nishima S, Simões EA; C-CREW Investigators
Pediatrics 2013 Nov;132(5):811-8. Epub 2013 Oct 14 doi: 10.1542/peds.2013-0982. [Epub ahead of print] PMID: 24127479
Deming DJ, Patel N, McCarthy MP, Mishra L, Shapiro AM, Suzich JA
Pediatr Infect Dis J 2013 Oct;32(10):1144-6. doi: 10.1097/INF.0b013e31829561dd. PMID: 23584584
Lundeen K, Pfeiffenberger T, Jacobson Vann J, O'Brien T, Sampson C, Wegner S
J Manag Care Pharm 2013 Mar;19(2):115-24. PMID: 23461427
Winterstein AG, Eworuke E, Xu D, Schuler P
Pediatr Pulmonol 2013 Sep;48(9):874-84. Epub 2012 Nov 8 doi: 10.1002/ppul.22711. [Epub ahead of print] PMID: 23139089
Santos RP, Chao J, Nepo AG, Butt S, Stellrecht KA, Pearce JM, Lepow ML
Pediatrics 2012 Dec;130(6):e1695-9. Epub 2012 Nov 12 doi: 10.1542/peds.2011-1768. [Epub ahead of print] PMID: 23147965

Therapy

Yoshihara S, Kusuda S, Mochizuki H, Okada K, Nishima S, Simões EA; C-CREW Investigators
Pediatrics 2013 Nov;132(5):811-8. Epub 2013 Oct 14 doi: 10.1542/peds.2013-0982. [Epub ahead of print] PMID: 24127479
Ohler KH, Pham JT
Am J Health Syst Pharm 2013 Aug 1;70(15):1342-6. doi: 10.2146/ajhp120526. PMID: 23867491
Robinson KA, Odelola OA, Saldanha IJ, McKoy NA
Cochrane Database Syst Rev 2013 Jun 5;6:CD007743. doi: 10.1002/14651858.CD007743.pub4. PMID: 23737087
La Via WV, Notario GF, Yu XQ, Sharma S, Noertersheuser PA, Robbie GJ
Pulm Pharmacol Ther 2013 Dec;26(6):666-71. Epub 2013 Mar 19 doi: 10.1016/j.pupt.2013.03.007. [Epub ahead of print] PMID: 23523663
Lundeen K, Pfeiffenberger T, Jacobson Vann J, O'Brien T, Sampson C, Wegner S
J Manag Care Pharm 2013 Mar;19(2):115-24. PMID: 23461427

Prognosis

Yi H, Lanctôt KL, Bont L, Bloemers BL, Weijerman M, Broers C, Li A, Kiss A, Mitchell I, Paes B; CARESS investigators
Pediatrics 2014 Jun;133(6):1031-7. Epub 2014 May 5 doi: 10.1542/peds.2013-3916. [Epub ahead of print] PMID: 24799541
Yoshihara S, Kusuda S, Mochizuki H, Okada K, Nishima S, Simões EA; C-CREW Investigators
Pediatrics 2013 Nov;132(5):811-8. Epub 2013 Oct 14 doi: 10.1542/peds.2013-0982. [Epub ahead of print] PMID: 24127479
Winterstein AG, Hampp C, Saidi A
Pharmacoepidemiol Drug Saf 2012 Jan;21(1):53-60. Epub 2011 Sep 15 doi: 10.1002/pds.2246. [Epub ahead of print] PMID: 21919115
Wang D, Bayliss S, Meads C
Health Technol Assess 2011 Jan;15(5):iii-iv, 1-124. doi: 10.3310/hta15050. PMID: 21281564
Chang SG, Park MS, Yu JE
J Korean Med Sci 2010 Feb;25(2):251-6. Epub 2010 Jan 19 doi: 10.3346/jkms.2010.25.2.251. PMID: 20119579Free PMC Article

Clinical prediction guides

Yoshihara S, Kusuda S, Mochizuki H, Okada K, Nishima S, Simões EA; C-CREW Investigators
Pediatrics 2013 Nov;132(5):811-8. Epub 2013 Oct 14 doi: 10.1542/peds.2013-0982. [Epub ahead of print] PMID: 24127479
La Via WV, Notario GF, Yu XQ, Sharma S, Noertersheuser PA, Robbie GJ
Pulm Pharmacol Ther 2013 Dec;26(6):666-71. Epub 2013 Mar 19 doi: 10.1016/j.pupt.2013.03.007. [Epub ahead of print] PMID: 23523663
Lundeen K, Pfeiffenberger T, Jacobson Vann J, O'Brien T, Sampson C, Wegner S
J Manag Care Pharm 2013 Mar;19(2):115-24. PMID: 23461427
Winterstein AG, Eworuke E, Xu D, Schuler P
Pediatr Pulmonol 2013 Sep;48(9):874-84. Epub 2012 Nov 8 doi: 10.1002/ppul.22711. [Epub ahead of print] PMID: 23139089
Hussman JM, Lanctôt KL, Paes B
J Med Econ 2013;16(1):115-24. Epub 2012 Oct 10 doi: 10.3111/13696998.2012.734886. [Epub ahead of print] PMID: 23016567

Recent systematic reviews

Robinson KA, Odelola OA, Saldanha IJ, McKoy NA
Cochrane Database Syst Rev 2013 Jun 5;6:CD007743. doi: 10.1002/14651858.CD007743.pub4. PMID: 23737087
Hussman JM, Lanctôt KL, Paes B
J Med Econ 2013;16(1):115-24. Epub 2012 Oct 10 doi: 10.3111/13696998.2012.734886. [Epub ahead of print] PMID: 23016567
Hussman JM, Li A, Paes B, Lanctôt KL
Expert Rev Pharmacoecon Outcomes Res 2012 Oct;12(5):553-67. Epub 2012 Nov 11 doi: 10.1586/erp.12.45. [Epub ahead of print] PMID: 23140255
Robbie GJ, Zhao L, Mondick J, Losonsky G, Roskos LK
Antimicrob Agents Chemother 2012 Sep;56(9):4927-36. Epub 2012 Jul 16 doi: 10.1128/AAC.06446-11. [Epub ahead of print] PMID: 22802243Free PMC Article
Robinson KA, Odelola OA, Saldanha IJ, McKoy NA
Cochrane Database Syst Rev 2012 Feb 15;2:CD007743. doi: 10.1002/14651858.CD007743.pub3. PMID: 22336832

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