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Cantharidin

MedGen UID:
739
Concept ID:
C0006886
Pharmacologic Substance
Synonyms: 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aalpha,4beta,7beta,7aalpha)-; Cantharidine
SNOMED CT: Cantharidin (86218002); Cantharidin (437975006)
 

Definition

A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally. [from MeSH]

Recent clinical studies

Etiology

Lao M, Weissler A, Siegfried E
J Am Acad Dermatol 2013 Aug;69(2):e47. doi: 10.1016/j.jaad.2013.04.023. PMID: 23866889
Zhan YP, Huang XE, Cao J, Lu YY, Wu XY, Liu J, Xu X, Xu L, Xiang J, Ye LH
Asian Pac J Cancer Prev 2012;13(9):4773-6. PMID: 23167418
Kaçar N, Taşlı L, Korkmaz S, Ergin S, Erdoğan BŞ
J Eur Acad Dermatol Venereol 2012 Jul;26(7):889-93. Epub 2011 Jul 26 doi: 10.1111/j.1468-3083.2011.04186.x. [Epub ahead of print] PMID: 21790794
Dinh PH, Corraza F, Mestdagh K, Kassengera Z, Doyen V, Michel O
Br J Clin Pharmacol 2011 Dec;72(6):912-20. doi: 10.1111/j.1365-2125.2011.04020.x. PMID: 21595743Free PMC Article
Cathcart S, Coloe J, Morrell DS
Clin Pediatr (Phila) 2009 Mar;48(2):161-5. Epub 2008 Oct 20 doi: 10.1177/0009922808326085. [Epub ahead of print] PMID: 18936288

Diagnosis

Kadioglu O, Kermani NS, Kelter G, Schumacher U, Fiebig HH, Greten HJ, Efferth T
Biochem Pharmacol 2014 Feb 1;87(3):399-409. Epub 2013 Nov 11 doi: 10.1016/j.bcp.2013.10.025. [Epub ahead of print] PMID: 24231507
Moye V, Cathcart S, Burkhart CN, Morrell DS
Dermatol Ther 2013 Nov-Dec;26(6):445-51. doi: 10.1111/dth.12105. PMID: 24552407
Chen X, Zhang Y
Int J Mol Sci 2013 Oct 15;14(10):20692-703. doi: 10.3390/ijms141020692. PMID: 24132154Free PMC Article
Bonness K, Aragon IV, Rutland B, Ofori-Acquah S, Dean NM, Honkanen RE
Mol Cancer Ther 2006 Nov;5(11):2727-36. doi: 10.1158/1535-7163.MCT-06-0273. PMID: 17121919
Zhang JP, Ying K, Xiao ZY, Zhou B, Huang QS, Wu HM, Yin M, Xie Y, Mao YM, Rui YC
Int J Cancer 2004 Jan 10;108(2):212-8. doi: 10.1002/ijc.11405. PMID: 14639605

Therapy

Moye V, Cathcart S, Burkhart CN, Morrell DS
Dermatol Ther 2013 Nov-Dec;26(6):445-51. doi: 10.1111/dth.12105. PMID: 24552407
Kim JA, Kim Y, Kwon BM, Han DC
J Biol Chem 2013 Oct 4;288(40):28713-26. Epub 2013 Aug 27 doi: 10.1074/jbc.M113.488346. [Epub ahead of print] PMID: 23983126Free PMC Article
Puerto Galvis CE, Vargas Méndez LY, Kouznetsov VV
Chem Biol Drug Des 2013 Nov;82(5):477-99. Epub 2013 Aug 9 doi: 10.1111/cbdd.12180. [Epub ahead of print] PMID: 23809227
Verma AK, Prasad SB
Anticancer Agents Med Chem 2013 Sep;13(7):1096-114. PMID: 23343079
Deng LP, Dong J, Cai H, Wang W
Curr Med Chem 2013;20(2):159-66. PMID: 23210849

Prognosis

van Berge L, Hamilton EM, Linnankivi T, Uziel G, Steenweg ME, Isohanni P, Wolf NI, Krägeloh-Mann I, Brautaset NJ, Andrews PI, de Jong BA, al Ghamdi M, van Wieringen WN, Tannous BA, Hulleman E, Würdinger T, van Berkel CG, Polder E, Abbink TE, Struys EA, Scheper GC, van der Knaap MS; LBSL Research Group
Brain 2014 Apr;137(Pt 4):1019-29. Epub 2014 Feb 24 doi: 10.1093/brain/awu026. [Epub ahead of print] PMID: 24566671
Kadioglu O, Kermani NS, Kelter G, Schumacher U, Fiebig HH, Greten HJ, Efferth T
Biochem Pharmacol 2014 Feb 1;87(3):399-409. Epub 2013 Nov 11 doi: 10.1016/j.bcp.2013.10.025. [Epub ahead of print] PMID: 24231507
Zhan YP, Huang XE, Cao J, Lu YY, Wu XY, Liu J, Xu X, Xu L, Xiang J, Ye LH
Asian Pac J Cancer Prev 2012;13(9):4773-6. PMID: 23167418
Cathcart S, Coloe J, Morrell DS
Clin Pediatr (Phila) 2009 Mar;48(2):161-5. Epub 2008 Oct 20 doi: 10.1177/0009922808326085. [Epub ahead of print] PMID: 18936288
Kartal Durmazlar SP, Atacan D, Eskioglu F
J Dermatolog Treat 2009;20(2):114-9. doi: 10.1080/09546630802287546. PMID: 18821118

Clinical prediction guides

Kadioglu O, Kermani NS, Kelter G, Schumacher U, Fiebig HH, Greten HJ, Efferth T
Biochem Pharmacol 2014 Feb 1;87(3):399-409. Epub 2013 Nov 11 doi: 10.1016/j.bcp.2013.10.025. [Epub ahead of print] PMID: 24231507
Verma AK, Prasad SB
Anticancer Agents Med Chem 2013 Sep;13(7):1096-114. PMID: 23343079
Zhan YP, Huang XE, Cao J, Lu YY, Wu XY, Liu J, Xu X, Xu L, Xiang J, Ye LH
Asian Pac J Cancer Prev 2012;13(9):4773-6. PMID: 23167418
Dinh PH, Corraza F, Mestdagh K, Kassengera Z, Doyen V, Michel O
Br J Clin Pharmacol 2011 Dec;72(6):912-20. doi: 10.1111/j.1365-2125.2011.04020.x. PMID: 21595743Free PMC Article
Huang WW, Ko SW, Tsai HY, Chung JG, Chiang JH, Chen KT, Chen YC, Chen HY, Chen YF, Yang JS
Int J Oncol 2011 Apr;38(4):1067-73. Epub 2011 Jan 24 doi: 10.3892/ijo.2011.922. [Epub ahead of print] PMID: 21271215

Recent systematic reviews

Chen L, Huang GZ
Forensic Sci Int 2013 Oct 10;232(1-3):e12-23. Epub 2013 Aug 19 doi: 10.1016/j.forsciint.2013.08.013. [Epub ahead of print] PMID: 24008199
Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R
Cochrane Database Syst Rev 2012 Sep 12;9:CD001781. doi: 10.1002/14651858.CD001781.pub3. PMID: 22972052
Coloe J, Burkhart CN, Morrell DS
Pediatr Ann 2009 Jun;38(6):321-5. PMID: 19588675

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