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Antidepressive Agents

MedGen UID:
1588
Concept ID:
C0003289
Pharmacologic Substance
Synonyms: Agents, Antidepressive; Antidepressant Drugs; Antidepressants; Drugs, Antidepressant
SNOMED CT: Antidepressant (372720008); Antidepressant (36236003)
 

Definition

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several monoamine oxidase inhibitors are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents also appear to act through brain catecholamine systems. A third group is a diverse group of drugs including some that act specifically on serotonergic systems. (MeSH) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGAntidepressive Agents

Recent clinical studies

Etiology

Huybrechts KF, Palmsten K, Avorn J, Cohen LS, Holmes LB, Franklin JM, Mogun H, Levin R, Kowal M, Setoguchi S, Hernández-Díaz S
N Engl J Med 2014 Jun 19;370(25):2397-407. doi: 10.1056/NEJMoa1312828. PMID: 24941178Free PMC Article
Guaiana G, Gupta S, Chiodo D, Davies SJ, Haederle K, Koesters M
Cochrane Database Syst Rev 2013 Dec 17;12:CD008851. doi: 10.1002/14651858.CD008851.pub2. PMID: 24343836
Tsai CJ, Loh el-W, Lin CH, Yu TM, Chan CH, Lan TH
Nephrology (Carlton) 2012 May;17(4):390-7. doi: 10.1111/j.1440-1797.2012.01571.x. PMID: 22260522
Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R, Furukawa TA
Cochrane Database Syst Rev 2011 Dec 7;(12):CD006528. doi: 10.1002/14651858.CD006528.pub2. PMID: 22161405
Nakagawa A, Watanabe N, Omori IM, Barbui C, Cipriani A, McGuire H, Churchill R, Furukawa TA
Cochrane Database Syst Rev 2009 Jul 8;(3):CD006529. doi: 10.1002/14651858.CD006529.pub2. PMID: 19588396

Diagnosis

Magni LR, Purgato M, Gastaldon C, Papola D, Furukawa TA, Cipriani A, Barbui C
Cochrane Database Syst Rev 2013 Jul 17;7:CD004185. PMID: 24353997
Chang HH, Chi MH, Lee IH, Tsai HC, Gean PW, Yang YK, Lu RB, Chen PS
J Affect Disord 2013 Sep 5;150(2):295-9. Epub 2013 May 9 doi: 10.1016/j.jad.2013.04.008. [Epub ahead of print] PMID: 23664565
Bschor T, Uhr M, Baethge C, Lewitzka U, Ising M, Erbe S, Winkelmann P, Ritter D
J Clin Psychopharmacol 2013 Feb;33(1):38-44. doi: 10.1097/JCP.0b013e31827b9495. PMID: 23277245
Vestergaard P, Prieto-Alhambra D, Javaid MK, Cooper C
Osteoporos Int 2013 Feb;24(2):671-80. Epub 2012 Jun 6 doi: 10.1007/s00198-012-2043-5. [Epub ahead of print] PMID: 22669469Free PMC Article
Tsai CJ, Loh el-W, Lin CH, Yu TM, Chan CH, Lan TH
Nephrology (Carlton) 2012 May;17(4):390-7. doi: 10.1111/j.1440-1797.2012.01571.x. PMID: 22260522

Therapy

Huybrechts KF, Palmsten K, Avorn J, Cohen LS, Holmes LB, Franklin JM, Mogun H, Levin R, Kowal M, Setoguchi S, Hernández-Díaz S
N Engl J Med 2014 Jun 19;370(25):2397-407. doi: 10.1056/NEJMoa1312828. PMID: 24941178Free PMC Article
Guaiana G, Gupta S, Chiodo D, Davies SJ, Haederle K, Koesters M
Cochrane Database Syst Rev 2013 Dec 17;12:CD008851. doi: 10.1002/14651858.CD008851.pub2. PMID: 24343836
Huang CC, Wei IH, Huang CL, Chen KT, Tsai MH, Tsai P, Tun R, Huang KH, Chang YC, Lane HY, Tsai GE
Biol Psychiatry 2013 Nov 15;74(10):734-41. Epub 2013 Apr 3 doi: 10.1016/j.biopsych.2013.02.020. [Epub ahead of print] PMID: 23562005
Tsai CJ, Loh el-W, Lin CH, Yu TM, Chan CH, Lan TH
Nephrology (Carlton) 2012 May;17(4):390-7. doi: 10.1111/j.1440-1797.2012.01571.x. PMID: 22260522
Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R, Furukawa TA
Cochrane Database Syst Rev 2011 Dec 7;(12):CD006528. doi: 10.1002/14651858.CD006528.pub2. PMID: 22161405

Prognosis

Vataire AL, Aballéa S, Antonanzas F, Roijen LH, Lam RW, McCrone P, Persson U, Toumi M
Value Health 2014 Mar;17(2):183-95. doi: 10.1016/j.jval.2013.11.012. PMID: 24636376
Huang CC, Wei IH, Huang CL, Chen KT, Tsai MH, Tsai P, Tun R, Huang KH, Chang YC, Lane HY, Tsai GE
Biol Psychiatry 2013 Nov 15;74(10):734-41. Epub 2013 Apr 3 doi: 10.1016/j.biopsych.2013.02.020. [Epub ahead of print] PMID: 23562005
Nordenskjöld A, von Knorring L, Ljung T, Carlborg A, Brus O, Engström I
J ECT 2013 Jun;29(2):86-92. doi: 10.1097/YCT.0b013e318276591f. PMID: 23303421
Bschor T, Uhr M, Baethge C, Lewitzka U, Ising M, Erbe S, Winkelmann P, Ritter D
J Clin Psychopharmacol 2013 Feb;33(1):38-44. doi: 10.1097/JCP.0b013e31827b9495. PMID: 23277245
Tsai CJ, Loh el-W, Lin CH, Yu TM, Chan CH, Lan TH
Nephrology (Carlton) 2012 May;17(4):390-7. doi: 10.1111/j.1440-1797.2012.01571.x. PMID: 22260522

Clinical prediction guides

Huybrechts KF, Palmsten K, Avorn J, Cohen LS, Holmes LB, Franklin JM, Mogun H, Levin R, Kowal M, Setoguchi S, Hernández-Díaz S
N Engl J Med 2014 Jun 19;370(25):2397-407. doi: 10.1056/NEJMoa1312828. PMID: 24941178Free PMC Article
Magni LR, Purgato M, Gastaldon C, Papola D, Furukawa TA, Cipriani A, Barbui C
Cochrane Database Syst Rev 2013 Jul 17;7:CD004185. PMID: 24353997
Chua EW, Foulds J, Miller AL, Kennedy MA
Pharmacogenet Genomics 2013 Sep;23(9):494-7. doi: 10.1097/FPC.0b013e328363688d. PMID: 23799451
Huang CC, Wei IH, Huang CL, Chen KT, Tsai MH, Tsai P, Tun R, Huang KH, Chang YC, Lane HY, Tsai GE
Biol Psychiatry 2013 Nov 15;74(10):734-41. Epub 2013 Apr 3 doi: 10.1016/j.biopsych.2013.02.020. [Epub ahead of print] PMID: 23562005
Tsai CJ, Loh el-W, Lin CH, Yu TM, Chan CH, Lan TH
Nephrology (Carlton) 2012 May;17(4):390-7. doi: 10.1111/j.1440-1797.2012.01571.x. PMID: 22260522

Recent systematic reviews

Guaiana G, Gupta S, Chiodo D, Davies SJ, Haederle K, Koesters M
Cochrane Database Syst Rev 2013 Dec 17;12:CD008851. doi: 10.1002/14651858.CD008851.pub2. PMID: 24343836
Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R, Furukawa TA
Cochrane Database Syst Rev 2011 Dec 7;(12):CD006528. doi: 10.1002/14651858.CD006528.pub2. PMID: 22161405
Cipriani A, La Ferla T, Furukawa TA, Signoretti A, Nakagawa A, Churchill R, McGuire H, Barbui C
Cochrane Database Syst Rev 2010 Apr 14;(4):CD006117. doi: 10.1002/14651858.CD006117.pub4. PMID: 20393946
Cipriani A, La Ferla T, Furukawa TA, Signoretti A, Nakagawa A, Churchill R, McGuire H, Barbui C
Cochrane Database Syst Rev 2010 Jan 20;(1):CD006117. doi: http://dx.doi.org/10.1002/14651858.CD006117. PMID: 20091586
Nakagawa A, Watanabe N, Omori IM, Barbui C, Cipriani A, McGuire H, Churchill R, Furukawa TA
Cochrane Database Syst Rev 2009 Jul 8;(3):CD006529. doi: 10.1002/14651858.CD006529.pub2. PMID: 19588396

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