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Results: 1 to 20 of 35

1.

Cyclophosphamide

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. [from MeSH]

MedGen UID:
4107
Concept ID:
C0010583
Pharmacologic Substance
2.

Does not

MedGen UID:
721427
Concept ID:
C1299585
Finding
3.

Related

MedGen UID:
619805
Concept ID:
C0445223
Finding
4.

Graft-versus-host disease, susceptibility to

Transplantation of hematopoietic stem cells is a successful therapy for some tumors derived from bone marrow precursors, such as certain leukemias and lymphomas, and it can be used to cure some primary immunodeficiencies and inherited hematopoietic stem-cell diseases. One of the major complications of allogeneic bone marrow transplantation is graft-versus-host disease (GVHD), in which mature donor T cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease. GVHD is particularly virulent when there is a mismatch of a major major histocompatibility complex (MHC) class I or class II antigen. Most transplants are therefore undertaken only when the donor and recipient are HLA-matched sibs or, less frequently, when there is an HLA-matched unrelated donor. However, GVHD also occurs in the context of disparities between minor histocompatibility antigens, and immunosuppression must be used in every stem-cell transplant (summary by Janeway et al., 2005). At the core of the immunogenetic basis for GVHD is the diversity of HLA, killer immunoglobulin-like receptors (KIRs; see 604936), and cytokine genes. HLA class I molecules function as ligands for natural killer cell inhibitory KIRs, indicating that GVHD results from a complex interplay between innate and adaptive immune responses. Cytokines may modulate the intensity of tissue injury and inflammation in GVHD, and therefore cytokine polymorphisms in either patient or donor or both may explain individual risks of GVHD (review by Petersdorf and Malkki, 2006). [from OMIM]

MedGen UID:
482307
Concept ID:
C3280677
Finding
5.

Ability to balance

The maintenance of a stable, upright body position. [from NCI]

MedGen UID:
154340
Concept ID:
C0560184
Finding
6.

Acute

Symptoms or signs that begin and worsen quickly; not chronic. [from NCI]

MedGen UID:
61381
Concept ID:
C0205178
7.

Graft versus host disease

The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION. [from MeSH]

MedGen UID:
9082
Concept ID:
C0018133
Disease or Syndrome
8.

Cytophosphan

MedGen UID:
501178
Concept ID:
C3495431
Pharmacologic Substance
9.

Recurrence (disease attribute)

The return of a sign, symptom, or disease after a remission. [from MeSH]

MedGen UID:
416712
Concept ID:
C2825055
Pathologic Function
10.

Immunomodulators

agents of both drug and biological origin often used in immunotherapy to stimulate, potentiate, or depress the immune response; also used to inhibit or enhance specific subclasses of immunocytes. [from CRISP]

MedGen UID:
282900
Concept ID:
C1527392
Pharmacologic Substance
11.

Disease Attributes

Clinical characteristics of disease or illness. [from MeSH]

MedGen UID:
199876
Concept ID:
C0752357
Disease or Syndrome
12.

NSC-26271

MedGen UID:
196095
Concept ID:
C0701106
Pharmacologic Substance
13.

Procytox

MedGen UID:
195870
Concept ID:
C0699322
Pharmacologic Substance
14.

Endoxan

MedGen UID:
195869
Concept ID:
C0699320
Pharmacologic Substance
15.

B-518

MedGen UID:
148718
Concept ID:
C0701107
Pharmacologic Substance
16.

Sendoxan

MedGen UID:
148481
Concept ID:
C0699323
Pharmacologic Substance
17.

Neosar

MedGen UID:
148480
Concept ID:
C0699321
Pharmacologic Substance
18.

Cytoxan

A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent. [from NCI]

MedGen UID:
148479
Concept ID:
C0699319
Pharmacologic Substance
19.

Hematologic neoplasm

Cancers of the blood or bone marrow, including leukemia and lymphoma. Also called hematologic cancers. [from NCI]

MedGen UID:
138213
Concept ID:
C0376545
Neoplastic Process
20.

Nitrogen Mustard Compounds

A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens. [from MeSH]

MedGen UID:
18053
Concept ID:
C0028165
Pharmacologic Substance

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