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Triclosan

MedGen UID:
11910
Concept ID:
C0040958
Pharmacologic Substance
Synonyms: 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether; 2-Hydroxy-2',4,4'-trichlorodiphenyl Ether; Cliniclean; Pharmachem Brand of Triclosan; Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-; Reckitt Brand of Triclosan; Sapoderm; Triclosan Pharmachem Brand; Triclosan Reckitt Brand
SNOMED CT: Triclosan product (125577003); Triclosan (387054001); Triclosan (125577003)
 

Definition

A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGTriclosan

Recent clinical studies

Etiology

Ros-Llor I, Lopez-Jornet P
Environ Res 2014 Jul;132:140-5. Epub 2014 Apr 25 doi: 10.1016/j.envres.2014.03.032. [Epub ahead of print] PMID: 24769563
Diener MK, Knebel P, Kieser M, Schüler P, Schiergens TS, Atanassov V, Neudecker J, Stein E, Thielemann H, Kunz R, von Frankenberg M, Schernikau U, Bunse J, Jansen-Winkeln B, Partecke LI, Prechtl G, Pochhammer J, Bouchard R, Hodina R, Beckurts KT, Leißner L, Lemmens HP, Kallinowski F, Thomusch O, Seehofer D, Simon T, Hyhlik-Dürr A, Seiler CM, Hackert T, Reissfelder C, Hennig R, Doerr-Harim C, Klose C, Ulrich A, Büchler MW
Lancet 2014 Jul 12;384(9938):142-52. Epub 2014 Apr 7 doi: 10.1016/S0140-6736(14)60238-5. [Epub ahead of print] PMID: 24718270
He T, Barker ML, Biesbrock AR, Eynon H, Milleman JL, Milleman KR, Putt MS, Wintergerst AM
Am J Dent 2013 Dec;26(6):303-6. PMID: 24640432
Riley P, Lamont T
Cochrane Database Syst Rev 2013 Dec 5;12:CD010514. doi: 10.1002/14651858.CD010514.pub2. PMID: 24310847
Thimour-Bergström L, Roman-Emanuel C, Scherstén H, Friberg Ö, Gudbjartsson T, Jeppsson A
Eur J Cardiothorac Surg 2013 Nov;44(5):931-8. Epub 2013 Feb 22 doi: 10.1093/ejcts/ezt063. [Epub ahead of print] PMID: 23435526Free PMC Article

Diagnosis

Provencher G, Bérubé R, Dumas P, Bienvenu JF, Gaudreau E, Bélanger P, Ayotte P
J Chromatogr A 2014 Jun 27;1348:97-104. Epub 2014 Apr 28 doi: 10.1016/j.chroma.2014.04.072. [Epub ahead of print] PMID: 24835763
Asimakopoulos AG, Wang L, Thomaidis NS, Kannan K
J Chromatogr A 2014 Jan 10;1324:141-8. Epub 2013 Nov 21 doi: 10.1016/j.chroma.2013.11.031. [Epub ahead of print] PMID: 24315674
Bertelsen RJ, Longnecker MP, Løvik M, Calafat AM, Carlsen KH, London SJ, Lødrup Carlsen KC
Allergy 2013 Jan;68(1):84-91. Epub 2012 Nov 12 doi: 10.1111/all.12058. [Epub ahead of print] PMID: 23146048Free PMC Article
Pera C, Ueda P, Casarin RC, Ribeiro FV, Pimentel SP, Casati MZ, Cirano FR
J Periodontol 2012 Jul;83(7):909-16. Epub 2011 Nov 16 doi: 10.1902/jop.2011.110348. [Epub ahead of print] PMID: 22087803
Baracs J, Huszár O, Sajjadi SG, Horváth OP
Surg Infect (Larchmt) 2011 Dec;12(6):483-9. Epub 2011 Dec 5 doi: 10.1089/sur.2011.001. [Epub ahead of print] PMID: 22142314

Therapy

Ros-Llor I, Lopez-Jornet P
Environ Res 2014 Jul;132:140-5. Epub 2014 Apr 25 doi: 10.1016/j.envres.2014.03.032. [Epub ahead of print] PMID: 24769563
Diener MK, Knebel P, Kieser M, Schüler P, Schiergens TS, Atanassov V, Neudecker J, Stein E, Thielemann H, Kunz R, von Frankenberg M, Schernikau U, Bunse J, Jansen-Winkeln B, Partecke LI, Prechtl G, Pochhammer J, Bouchard R, Hodina R, Beckurts KT, Leißner L, Lemmens HP, Kallinowski F, Thomusch O, Seehofer D, Simon T, Hyhlik-Dürr A, Seiler CM, Hackert T, Reissfelder C, Hennig R, Doerr-Harim C, Klose C, Ulrich A, Büchler MW
Lancet 2014 Jul 12;384(9938):142-52. Epub 2014 Apr 7 doi: 10.1016/S0140-6736(14)60238-5. [Epub ahead of print] PMID: 24718270
He T, Barker ML, Biesbrock AR, Eynon H, Milleman JL, Milleman KR, Putt MS, Wintergerst AM
Am J Dent 2013 Dec;26(6):303-6. PMID: 24640432
Riley P, Lamont T
Cochrane Database Syst Rev 2013 Dec 5;12:CD010514. doi: 10.1002/14651858.CD010514.pub2. PMID: 24310847
Thimour-Bergström L, Roman-Emanuel C, Scherstén H, Friberg Ö, Gudbjartsson T, Jeppsson A
Eur J Cardiothorac Surg 2013 Nov;44(5):931-8. Epub 2013 Feb 22 doi: 10.1093/ejcts/ezt063. [Epub ahead of print] PMID: 23435526Free PMC Article

Prognosis

He T, Barker ML, Biesbrock A, Miner M, Amini P, Goyal CR, Qaqish J
Am J Dent 2013 Aug;26(4):175-9. PMID: 24693625
He T, Barker ML, Biesbrock AR, Eynon H, Milleman JL, Milleman KR, Putt MS, Wintergerst AM
Am J Dent 2013 Dec;26(6):303-6. PMID: 24640432
Sharma N, He T, Barker ML, Biesbrock AR
J Clin Dent 2013;24(1):31-6. PMID: 23547492
Perez AL, De Sylor MA, Slocombe AJ, Lew MG, Unice KM, Donovan EP
Environ Toxicol Chem 2013 Jul;32(7):1479-87. Epub 2013 May 29 doi: 10.1002/etc.2217. [Epub ahead of print] PMID: 23471841
Kumar S, Patel S, Tadakamadla J, Tibdewal H, Duraiswamy P, Kulkarni S
Int J Dent Hyg 2013 Feb;11(1):35-40. Epub 2012 Jun 4 doi: 10.1111/j.1601-5037.2012.00560.x. [Epub ahead of print] PMID: 22672130

Clinical prediction guides

Ros-Llor I, Lopez-Jornet P
Environ Res 2014 Jul;132:140-5. Epub 2014 Apr 25 doi: 10.1016/j.envres.2014.03.032. [Epub ahead of print] PMID: 24769563
Asimakopoulos AG, Thomaidis NS, Kannan K
Sci Total Environ 2014 Feb 1;470-471:1243-9. Epub 2013 Nov 16 doi: 10.1016/j.scitotenv.2013.10.089. [Epub ahead of print] PMID: 24246946
He T, Barker ML, Biesbrock A, Miner M, Amini P, Goyal CR, Qaqish J
Am J Dent 2013 Aug;26(4):175-9. PMID: 24693625
Kumar S, Patel S, Tadakamadla J, Tibdewal H, Duraiswamy P, Kulkarni S
Int J Dent Hyg 2013 Feb;11(1):35-40. Epub 2012 Jun 4 doi: 10.1111/j.1601-5037.2012.00560.x. [Epub ahead of print] PMID: 22672130
Henry ND, Fair PA
J Appl Toxicol 2013 Apr;33(4):265-72. Epub 2011 Sep 21 doi: 10.1002/jat.1736. [Epub ahead of print] PMID: 21935973

Recent systematic reviews

Riley P, Lamont T
Cochrane Database Syst Rev 2013 Dec 5;12:CD010514. doi: 10.1002/14651858.CD010514.pub2. PMID: 24310847
Edmiston CE Jr, Daoud FC, Leaper D
Surgery 2013 Jul;154(1):89-100. doi: 10.1016/j.surg.2013.03.008. PMID: 23809487
Trombelli L, Farina R
Minerva Stomatol 2013 Mar;62(3):71-88. PMID: 23518778
Perez AL, De Sylor MA, Slocombe AJ, Lew MG, Unice KM, Donovan EP
Environ Toxicol Chem 2013 Jul;32(7):1479-87. Epub 2013 May 29 doi: 10.1002/etc.2217. [Epub ahead of print] PMID: 23471841
Chang WK, Srinivasa S, Morton R, Hill AG
Ann Surg 2012 May;255(5):854-9. doi: 10.1097/SLA.0b013e31824e7005. PMID: 22470067

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