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Results: 3

1.

Histiocytosis

a rare blood disease [from CHV]

MedGen UID:
6845
Concept ID:
C0019618
Pathologic Function
2.

Langerhans cell histiocytosis, multifocal

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the dysregulated proliferation of Langerhans cells and subsequent organ infiltration. Clinical manifestations range from a spontaneously healing isolated osteolytic lesion to a lymphoma-like syndrome with fatal multiorgan failure, in the absence of any cellular evidence of malignancy. Although the disease can present at any age, the peak age at diagnosis is between 1 and 3 years (summary by Arico et al., 1999). Egeler and D'Angio (1995) presented a classification of histiocytosis syndromes in children: class I, Langerhans cell histiocytosis (LCH); class II, histiocytosis of mononuclear macrophages other than Langerhans cells, including familial hemophagocytic lymphohistiocytosis (267700); and class III, malignant histiocytic disorders, including histiocytic lymphoma. [from OMIM]

MedGen UID:
5568
Concept ID:
C0019621
Neoplastic Process
3.

Bone lesion

MedGen UID:
116074
Concept ID:
C0238792
Disease or Syndrome

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