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Cysteamine

MedGen UID:
41390
Concept ID:
C0010648
Pharmacologic Substance
Synonyms: 2 Aminoethanethiol; 2-Aminoethanethiol; beta Mercaptoethylamine; beta-Mercaptoethylamine; Cysteinamine; Ethanethiol, 2-amino-; Mercamine; Mercaptamine
SNOMED CT: Cysteamine (373457005); Mercaptamine (109109007); Cysteamine (109109007); Mercaptamine (373457005)
 

Definition

A radiation-protective agent that oxidizes in air to form CYSTAMINE. It can be given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGCysteamine

Recent clinical studies

Etiology

Rahmat D, Müller C, Shahnaz G, Leithner K, Laffleur F, Khan MI, Martien R, Bernkop Schnürch A
Drug Dev Ind Pharm 2013 Sep;39(9):1338-45. Epub 2012 Aug 20 doi: 10.3109/03639045.2012.711834. [Epub ahead of print] PMID: 22901004
Sezgintürk MK, Uygun ZO
Anal Biochem 2012 Apr 15;423(2):277-85. Epub 2012 Jan 8 doi: 10.1016/j.ab.2011.12.049. [Epub ahead of print] PMID: 22266295
Rahmat D, Sakloetsakun D, Shahnaz G, Sarti F, Laffleur F, Schnürch AB
Int J Pharm 2012 Jan 17;422(1-2):40-6. Epub 2011 Oct 17 doi: 10.1016/j.ijpharm.2011.10.024. [Epub ahead of print] PMID: 22027393
Brodin-Sartorius A, Tête MJ, Niaudet P, Antignac C, Guest G, Ottolenghi C, Charbit M, Moyse D, Legendre C, Lesavre P, Cochat P, Servais A
Kidney Int 2012 Jan;81(2):179-89. Epub 2011 Sep 7 doi: 10.1038/ki.2011.277. [Epub ahead of print] PMID: 21900880
Noh HB, Rahman MA, Yang JE, Shim YB
Biosens Bioelectron 2011 Jul 15;26(11):4429-35. Epub 2011 May 6 doi: 10.1016/j.bios.2011.04.058. [Epub ahead of print] PMID: 21616656

Diagnosis

Karimi-Maleh H, Biparva P, Hatami M
Biosens Bioelectron 2013 Oct 15;48:270-5. Epub 2013 Apr 30 doi: 10.1016/j.bios.2013.04.029. [Epub ahead of print] PMID: 23707873
Dohil R, Cabrera BL
Pediatr Nephrol 2013 Mar;28(3):507-10. Epub 2012 Sep 25 doi: 10.1007/s00467-012-2315-5. [Epub ahead of print] PMID: 23001048
Besouw M, Tangerman A, Cornelissen E, Rioux P, Levtchenko E
Mol Genet Metab 2012 Sep;107(1-2):234-6. Epub 2012 Jul 6 doi: 10.1016/j.ymgme.2012.06.017. [Epub ahead of print] PMID: 22832073
Brodin-Sartorius A, Tête MJ, Niaudet P, Antignac C, Guest G, Ottolenghi C, Charbit M, Moyse D, Legendre C, Lesavre P, Cochat P, Servais A
Kidney Int 2012 Jan;81(2):179-89. Epub 2011 Sep 7 doi: 10.1038/ki.2011.277. [Epub ahead of print] PMID: 21900880
Shin YJ, Seo JM, Chung TY, Hyon JY, Wee WR
Curr Eye Res 2011 Oct;36(10):910-7. doi: 10.3109/02713683.2011.593726. PMID: 21950696

Therapy

Besouw MT, Schneider J, Janssen MC, Greco M, Emma F, Cornelissen EA, Desmet K, Skovby F, Nobili F, Lilien MR, De Paepe A, Malfait F, Symoens S, van den Heuvel LP, Levtchenko EN
J Pediatr 2013 Sep;163(3):754-60. Epub 2013 May 4 doi: 10.1016/j.jpeds.2013.03.078. [Epub ahead of print] PMID: 23651769
Besouw M, Masereeuw R, van den Heuvel L, Levtchenko E
Drug Discov Today 2013 Aug;18(15-16):785-92. Epub 2013 Feb 14 doi: 10.1016/j.drudis.2013.02.003. [Epub ahead of print] PMID: 23416144
Dohil R, Cabrera BL
Pediatr Nephrol 2013 Mar;28(3):507-10. Epub 2012 Sep 25 doi: 10.1007/s00467-012-2315-5. [Epub ahead of print] PMID: 23001048
Rahmat D, Müller C, Shahnaz G, Leithner K, Laffleur F, Khan MI, Martien R, Bernkop Schnürch A
Drug Dev Ind Pharm 2013 Sep;39(9):1338-45. Epub 2012 Aug 20 doi: 10.3109/03639045.2012.711834. [Epub ahead of print] PMID: 22901004
Dohil R, Meyer L, Schmeltzer S, Cabrera BL, Lavine JE, Phillips SA
J Pediatr 2012 Oct;161(4):639-45.e1. Epub 2012 May 24 doi: 10.1016/j.jpeds.2012.04.011. [Epub ahead of print] PMID: 22633783

Prognosis

Gonzalez-Gutierrez G, Lukk T, Agarwal V, Papke D, Nair SK, Grosman C
Proc Natl Acad Sci U S A 2012 Apr 17;109(16):6331-6. Epub 2012 Apr 2 doi: 10.1073/pnas.1119268109. [Epub ahead of print] PMID: 22474383Free PMC Article
Brodin-Sartorius A, Tête MJ, Niaudet P, Antignac C, Guest G, Ottolenghi C, Charbit M, Moyse D, Legendre C, Lesavre P, Cochat P, Servais A
Kidney Int 2012 Jan;81(2):179-89. Epub 2011 Sep 7 doi: 10.1038/ki.2011.277. [Epub ahead of print] PMID: 21900880
Rocha S, Martins LS, Vizcaíno R, Dias L, Almeida M, Pedroso S, Vidinha J, Rocha M, Rocha G, Mota C, Henriques A, Cabrita A
Transplant Proc 2011 Jul-Aug;43(6):2265-8. doi: 10.1016/j.transproceed.2011.05.009. PMID: 21839252
Greco M, Brugnara M, Zaffanello M, Taranta A, Pastore A, Emma F
Pediatr Nephrol 2010 Dec;25(12):2459-67. Epub 2010 Aug 29 doi: 10.1007/s00467-010-1641-8. [Epub ahead of print] PMID: 20803298
Krischock L, Horsfield C, D'Cruz D, Rigden SP
Nephrol Dial Transplant 2009 Jun;24(6):1997-9. Epub 2009 Mar 26 doi: 10.1093/ndt/gfp128. [Epub ahead of print] PMID: 19324914

Clinical prediction guides

Besouw M, Tangerman A, Cornelissen E, Rioux P, Levtchenko E
Mol Genet Metab 2012 Sep;107(1-2):234-6. Epub 2012 Jul 6 doi: 10.1016/j.ymgme.2012.06.017. [Epub ahead of print] PMID: 22832073
Rocha S, Martins LS, Vizcaíno R, Dias L, Almeida M, Pedroso S, Vidinha J, Rocha M, Rocha G, Mota C, Henriques A, Cabrita A
Transplant Proc 2011 Jul-Aug;43(6):2265-8. doi: 10.1016/j.transproceed.2011.05.009. PMID: 21839252
Dohil R, Schmeltzer S, Cabrera BL, Wang T, Durelle J, Duke KB, Schwimmer JB, Lavine JE
Aliment Pharmacol Ther 2011 May;33(9):1036-44. Epub 2011 Mar 13 doi: 10.1111/j.1365-2036.2011.04626.x. [Epub ahead of print] PMID: 21395631
Wilmer MJ, Kluijtmans LA, van der Velden TJ, Willems PH, Scheffer PG, Masereeuw R, Monnens LA, van den Heuvel LP, Levtchenko EN
Biochim Biophys Acta 2011 Jun;1812(6):643-51. Epub 2011 Feb 28 doi: 10.1016/j.bbadis.2011.02.010. [Epub ahead of print] PMID: 21371554
Gibrat C, Cicchetti F
Prog Neuropsychopharmacol Biol Psychiatry 2011 Mar 30;35(2):380-9. Epub 2010 Nov 24 doi: 10.1016/j.pnpbp.2010.11.023. [Epub ahead of print] PMID: 21111020

Recent systematic reviews

Brok J, Buckley N, Gluud C
Cochrane Database Syst Rev 2006 Apr 19;(2):CD003328. doi: 10.1002/14651858.CD003328.pub2. PMID: 16625578
Brok J, Buckley N, Gluud C
Cochrane Database Syst Rev 2002;(3):CD003328. doi: 10.1002/14651858.CD003328. PMID: 12137690

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