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Nicotine

MedGen UID:
18039
Concept ID:
C0028040
Pharmacologic Substance
Synonyms: Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-
SNOMED CT: Nicotine (68540007); Nicotine agent (373462006); Nicotine (323283001); Nicotine - chemical (68540007)
 

Definition

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGNicotine

Recent clinical studies

Etiology

Chen EY, Sun A, Chen CS, Mintz AJ, Chin WC
Am J Physiol Lung Cell Mol Physiol 2014 Jul 15;307(2):L149-57. Epub 2014 May 16 doi: 10.1152/ajplung.00396.2012. [Epub ahead of print] PMID: 24838753Free PMC Article
Ma X, Jia Y, Zu S, Li R, Jia Y, Zhao Y, Xiao D, Dang N, Wang Y
Toxicol Appl Pharmacol 2014 Jul 15;278(2):172-9. Epub 2014 Apr 30 doi: 10.1016/j.taap.2014.04.023. [Epub ahead of print] PMID: 24793809
Wolters A, de Wert G, van Schayck O, Horstman K
Soc Sci Med 2014 Mar;104:116-23. Epub 2013 Dec 18 doi: 10.1016/j.socscimed.2013.12.011. [Epub ahead of print] PMID: 24581069
Balmes JR, Cisternas M, Quinlan PJ, Trupin L, Lurmann FW, Katz PP, Blanc PD
Environ Res 2014 Feb;129:1-10. Epub 2014 Jan 11 doi: 10.1016/j.envres.2013.12.007. [Epub ahead of print] PMID: 24528996
Mishriky BM, Habib AS
Anesth Analg 2014 Aug;119(2):268-75. doi: 10.1213/ANE.0b013e3182a8fa7b. PMID: 24384863

Diagnosis

Mishriky BM, Habib AS
Anesth Analg 2014 Aug;119(2):268-75. doi: 10.1213/ANE.0b013e3182a8fa7b. PMID: 24384863
Earla R, Ande A, McArthur C, Kumar A, Kumar S
Drug Metab Dispos 2014 Feb;42(2):282-93. Epub 2013 Dec 3 doi: 10.1124/dmd.113.055186. [Epub ahead of print] PMID: 24301609Free PMC Article
Taki FA, Pan X, Zhang B
J Cell Physiol 2014 Jan;229(1):79-89. doi: 10.1002/jcp.24419. PMID: 23765240Free PMC Article
Evans S, Dowell NG, Tabet N, Tofts PS, King SL, Gray M, Rusted JM
J Psychopharmacol 2013 Nov;27(11):1007-14. Epub 2013 Aug 19 doi: 10.1177/0269881113499828. [Epub ahead of print] PMID: 23958867
Dempsey DA, St Helen G, Jacob P 3rd, Tyndale RF, Benowitz NL
Clin Pharmacol Ther 2013 Dec;94(6):687-94. Epub 2013 Aug 9 doi: 10.1038/clpt.2013.159. [Epub ahead of print] PMID: 23933970Free PMC Article

Therapy

Prescrire Int 2014 May;23(149):126-8. PMID: 24926513
Grando SA
Nat Rev Cancer 2014 Jun;14(6):419-29. Epub 2014 May 15 doi: 10.1038/nrc3725. [Epub ahead of print] PMID: 24827506
Wolters A, de Wert G, van Schayck O, Horstman K
Soc Sci Med 2014 Mar;104:116-23. Epub 2013 Dec 18 doi: 10.1016/j.socscimed.2013.12.011. [Epub ahead of print] PMID: 24581069
Balmes JR, Cisternas M, Quinlan PJ, Trupin L, Lurmann FW, Katz PP, Blanc PD
Environ Res 2014 Feb;129:1-10. Epub 2014 Jan 11 doi: 10.1016/j.envres.2013.12.007. [Epub ahead of print] PMID: 24528996
Mishriky BM, Habib AS
Anesth Analg 2014 Aug;119(2):268-75. doi: 10.1213/ANE.0b013e3182a8fa7b. PMID: 24384863

Prognosis

Iglesias V, Erazo M, Droppelmann A, Steenland K, Aceituno P, Orellana C, Acuña M, Peruga A, Breysse PN, Navas-Acien A
Environ Res 2014 Jul;132:206-11. Epub 2014 May 8 doi: 10.1016/j.envres.2014.03.044. [Epub ahead of print] PMID: 24813578
Wolters A, de Wert G, van Schayck O, Horstman K
Soc Sci Med 2014 Mar;104:116-23. Epub 2013 Dec 18 doi: 10.1016/j.socscimed.2013.12.011. [Epub ahead of print] PMID: 24581069
Zengin MO, Cinar E, Kucukerdonmez C
Br J Ophthalmol 2014 Feb;98(2):233-7. Epub 2013 Nov 13 doi: 10.1136/bjophthalmol-2013-304044. [Epub ahead of print] PMID: 24227806
Dickson PE, Miller MM, Rogers TD, Blaha CD, Mittleman G
Addict Biol 2014 Jan;19(1):37-48. Epub 2012 Sep 17 doi: 10.1111/j.1369-1600.2012.00496.x. [Epub ahead of print] PMID: 22978678Free PMC Article
Allen AM, Kleppinger A, Lando H, Oncken C
Eat Behav 2013 Dec;14(4):420-3. Epub 2013 Jul 21 doi: 10.1016/j.eatbeh.2013.07.007. [Epub ahead of print] PMID: 24183127Free PMC Article

Clinical prediction guides

Iglesias V, Erazo M, Droppelmann A, Steenland K, Aceituno P, Orellana C, Acuña M, Peruga A, Breysse PN, Navas-Acien A
Environ Res 2014 Jul;132:206-11. Epub 2014 May 8 doi: 10.1016/j.envres.2014.03.044. [Epub ahead of print] PMID: 24813578
Mishriky BM, Habib AS
Anesth Analg 2014 Aug;119(2):268-75. doi: 10.1213/ANE.0b013e3182a8fa7b. PMID: 24384863
Dickson PE, Miller MM, Rogers TD, Blaha CD, Mittleman G
Addict Biol 2014 Jan;19(1):37-48. Epub 2012 Sep 17 doi: 10.1111/j.1369-1600.2012.00496.x. [Epub ahead of print] PMID: 22978678Free PMC Article
Dinicola S, Morini V, Coluccia P, Proietti S, D'Anselmi F, Pasqualato A, Masiello MG, Palombo A, De Toma G, Bizzarri M, Cucina A
Toxicol In Vitro 2013 Dec;27(8):2256-63. Epub 2013 Oct 2 doi: 10.1016/j.tiv.2013.09.020. [Epub ahead of print] PMID: 24095863
Oliveira SC, Santarino IB, Enache TA, Nunes C, Laranjinha J, Barbosa RM, Oliveira-Brett AM
Bioelectrochemistry 2013 Dec;94:30-8. Epub 2013 May 30 doi: 10.1016/j.bioelechem.2013.05.004. [Epub ahead of print] PMID: 23774106

Recent systematic reviews

Mishriky BM, Habib AS
Anesth Analg 2014 Aug;119(2):268-75. doi: 10.1213/ANE.0b013e3182a8fa7b. PMID: 24384863
Bam TS, Bellew W, Berezhnova I, Jackson-Morris A, Jones A, Latif E, Molinari MA, Quan G, Singh RJ, Wisotzky M; Tobacco Control Department International Union Against Tuberculosis and Lung Disease
Int J Tuberc Lung Dis 2014 Jan;18(1):5-7. doi: 10.5588/ijtld.13.0815. PMID: 24365545
Stead LF, Perera R, Bullen C, Mant D, Hartmann-Boyce J, Cahill K, Lancaster T
Cochrane Database Syst Rev 2012 Nov 14;11:CD000146. doi: 10.1002/14651858.CD000146.pub4. PMID: 23152200
Brunzell DH
Nicotine Tob Res 2012 Nov;14(11):1258-69. Epub 2012 Apr 6 doi: 10.1093/ntr/nts089. [Epub ahead of print] PMID: 22492084Free PMC Article
Caldwell B, Sumner W, Crane J
Nicotine Tob Res 2012 Oct;14(10):1127-39. Epub 2012 Feb 29 doi: 10.1093/ntr/nts009. [Epub ahead of print] PMID: 22377934

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