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Heparin-induced thrombocytopenia

MedGen UID:
124423
Concept ID:
C0272285
Disease or Syndrome
Synonyms: HAT; Heparin Induced Thrombocytopenia; Heparin induced thrombocytopenia; Heparin-associated thrombocytopenia; Heparin-Induced Thrombocytopenia; Heparin-induced thrombocytopenia type 2; HIT
SNOMED CT: Heparin-induced thrombocytopenia (73397007); Heparin induced thrombocytopenia (73397007)
 
HPO: HP:0011874
Orphanet: ORPHA3325

Definition

Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeparin-induced thrombocytopenia
Follow this link to review classifications for Heparin-induced thrombocytopenia in Orphanet.

Recent clinical studies

Etiology

Vo QA, Lin JK, Tong LM
Ann Pharmacother 2015 Feb;49(2):178-84. Epub 2014 Dec 16 doi: 10.1177/1060028014562949. [Epub ahead of print] PMID: 25515865
Pericleous A, Sadek M, Fitzmaurice M, Caldwell C, Natividad K, Plestis KA
Tex Heart Inst J 2014 Dec;41(6):645-8. Epub 2014 Dec 1 doi: 10.14503/THIJ-13-3631. PMID: 25593533Free PMC Article
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. [Epub ahead of print] PMID: 24844576
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. [Epub ahead of print] PMID: 24726205
Benken ST, Tillman N, Dajani S, Shah A, Thomas T
J Cardiothorac Surg 2014 Mar 21;9:55. doi: 10.1186/1749-8090-9-55. [Epub ahead of print] PMID: 24656312Free PMC Article

Diagnosis

Vianello F, Sambado L, Scarparo P, Lombardi A, Bernardi D, Plebani M, Fabris F
Clin Chem Lab Med 2015 Feb;53(2):257-63. doi: 10.1515/cclm-2014-0809. PMID: 25324455
Jourdy Y, Nougier C, Rugeri L, Bordet JC, Sobas F, Negrier C
Int J Lab Hematol 2015 Apr;37(2):244-52. Epub 2014 Jul 15 doi: 10.1111/ijlh.12275. [Epub ahead of print] PMID: 25041633
Pericleous A, Sadek M, Fitzmaurice M, Caldwell C, Natividad K, Plestis KA
Tex Heart Inst J 2014 Dec;41(6):645-8. Epub 2014 Dec 1 doi: 10.14503/THIJ-13-3631. PMID: 25593533Free PMC Article
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. [Epub ahead of print] PMID: 24844576
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. [Epub ahead of print] PMID: 24726205

Therapy

Yuan SM
Pak J Pharm Sci 2015 Sep;28(5):1793-6. PMID: 26408899
Miyares MA, Davis KA
Ann Pharmacother 2015 Jun;49(6):735-9. Epub 2015 Apr 8 doi: 10.1177/1060028015579424. [Epub ahead of print] PMID: 25855702
Vianello F, Furian L, Nordio M, Treleani M, Fabris F
Hematology 2015 Jan;20(1):48-9. Epub 2014 Feb 28 doi: 10.1179/1607845414Y.0000000157. [Epub ahead of print] PMID: 24580134
Pericleous A, Sadek M, Fitzmaurice M, Caldwell C, Natividad K, Plestis KA
Tex Heart Inst J 2014 Dec;41(6):645-8. Epub 2014 Dec 1 doi: 10.14503/THIJ-13-3631. PMID: 25593533Free PMC Article
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. [Epub ahead of print] PMID: 24844576

Prognosis

Miyares MA, Davis KA
Ann Pharmacother 2015 Jun;49(6):735-9. Epub 2015 Apr 8 doi: 10.1177/1060028015579424. [Epub ahead of print] PMID: 25855702
Sharifi M, Bay C, Vajo Z, Freeman W, Sharifi M, Schwartz F
Thromb Res 2015 Apr;135(4):607-9. Epub 2015 Jan 10 doi: 10.1016/j.thromres.2015.01.009. [Epub ahead of print] PMID: 25613925
Leroux D, Hezard N, Lebreton A, Bauters A, Suchon P, de Maistre E, Biron C, Huisse MG, Ternisien C, Voisin S, Gruel Y, Pouplard C
Br J Haematol 2014 Sep;166(5):774-82. Epub 2014 May 12 doi: 10.1111/bjh.12939. [Epub ahead of print] PMID: 24815503
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. [Epub ahead of print] PMID: 24726205
Benken ST, Tillman N, Dajani S, Shah A, Thomas T
J Cardiothorac Surg 2014 Mar 21;9:55. doi: 10.1186/1749-8090-9-55. [Epub ahead of print] PMID: 24656312Free PMC Article

Clinical prediction guides

Miyares MA, Davis KA
Ann Pharmacother 2015 Jun;49(6):735-9. Epub 2015 Apr 8 doi: 10.1177/1060028015579424. [Epub ahead of print] PMID: 25855702
Vianello F, Sambado L, Scarparo P, Lombardi A, Bernardi D, Plebani M, Fabris F
Clin Chem Lab Med 2015 Feb;53(2):257-63. doi: 10.1515/cclm-2014-0809. PMID: 25324455
Jourdy Y, Nougier C, Rugeri L, Bordet JC, Sobas F, Negrier C
Int J Lab Hematol 2015 Apr;37(2):244-52. Epub 2014 Jul 15 doi: 10.1111/ijlh.12275. [Epub ahead of print] PMID: 25041633
Leroux D, Hezard N, Lebreton A, Bauters A, Suchon P, de Maistre E, Biron C, Huisse MG, Ternisien C, Voisin S, Gruel Y, Pouplard C
Br J Haematol 2014 Sep;166(5):774-82. Epub 2014 May 12 doi: 10.1111/bjh.12939. [Epub ahead of print] PMID: 24815503
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. [Epub ahead of print] PMID: 24726205

Recent systematic reviews

Miyares MA, Davis KA
Ann Pharmacother 2015 Jun;49(6):735-9. Epub 2015 Apr 8 doi: 10.1177/1060028015579424. [Epub ahead of print] PMID: 25855702
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. [Epub ahead of print] PMID: 24726205
Tessler O, Vorstenbosch J, Jones D, Lalonde S, Zadeh T
Microsurgery 2014 Feb;34(2):157-63. Epub 2013 Oct 21 doi: 10.1002/micr.22190. [Epub ahead of print] PMID: 24142745
Bhatt VR, Aryal MR, Shrestha R, Armitage JO
Eur J Haematol 2013 Nov;91(5):437-41. Epub 2013 Aug 20 doi: 10.1111/ejh.12179. [Epub ahead of print] PMID: 23905719
Avila ML, Shah V, Brandão LR
J Thromb Haemost 2013 Apr;11(4):660-9. doi: 10.1111/jth.12153. PMID: 23350790

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