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Poor wound healing

MedGen UID:
377525
Concept ID:
C1851789
Finding
 
HPO: HP:0001058

Definition

A reduced ability to heal cutaneous wounds. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoor wound healing

Conditions with this feature

Pituitary dependent hypercortisolism
MedGen UID:
66381
Concept ID:
C0221406
Disease or Syndrome
Cushing 'disease' is a condition associated with increased blood cortisol resulting from adrenocorticotropic hormone (ACTH)-producing pituitary tumors that are resistant to glucocorticoid negative feedback (Bilodeau et al., 2006). ACTH is formed as a precursor from the POMC gene product (176830). See also Cushing 'syndrome' (219080), in which excess cortisol secretion results from adrenocortical pathology.
Ehlers-Danlos syndrome, classic type
MedGen UID:
78660
Concept ID:
C0268335
Disease or Syndrome
Ehlers-Danlos syndrome (EDS), classic type is a connective tissue disorder characterized by skin hyperextensibility, abnormal wound healing, and joint hypermobility. It includes two previously designated subtypes (EDS type I and EDS type II) that are now recognized to form a continuum of clinical findings. The skin is smooth, velvety to the touch, and hyperelastic; i.e., it extends easily and snaps back after release (unlike lax, redundant skin, as in cutis laxa). The skin is fragile, as manifested by splitting of the dermis following relatively minor trauma, especially over pressure points (knees, elbows) and areas prone to trauma (shins, forehead, chin). Wound healing is delayed, and stretching of scars after apparently successful primary wound healing is characteristic. Complications of joint hypermobility, such as dislocations of the shoulder, patella, digits, hip, radius, and clavicle, usually resolve spontaneously or are easily managed by the affected individual. Other features include hypotonia with delayed motor development, fatigue and muscle cramps, and easy bruising. Less common findings include mitral and tricuspid valve prolapse, aortic root dilatation, and spontaneous rupture of large arteries.
Ehlers-Danlos syndrome, procollagen proteinase deficient
MedGen UID:
78662
Concept ID:
C0268345
Disease or Syndrome
EDS type VII is distinguished from the other types of EDS by the frequency of congenital hip dislocation and extreme joint laxity with recurrent joint subluxations and minimal skin involvement (Byers et al., 1997; Giunta et al., 2008). Beighton et al. (1998) reported on a revised nosology of the Ehlers-Danlos syndromes, designated the Villefranche classification. Major and minor diagnostic criteria were defined for each type and complemented whenever possible with laboratory findings. Six main descriptive types were substituted for earlier types numbered with Roman numerals: classic type (EDS I and II), hypermobility type (EDS III), vascular type (EDS IV), kyphoscoliosis type (EDS VI), arthrochalasia type (EDS VIIA and VIIB), and dermatosparaxis type (EDS VIIC). Six other forms were listed, including a category of 'unspecified forms.'
Ehlers-Danlos syndrome, type 8
MedGen UID:
82791
Concept ID:
C0268347
Congenital Abnormality
The Ehlers-Danlos syndromes (EDS) constitute a family of inherited disorders of connective tissue that share the common features of joint hypermobility and skin abnormalities. EDS type VIII is distinguished from other EDS subtypes by severe gingival recession and periodontitis leading to premature loss of permanent teeth and resorption of alveolar bone by the third decade of life, as well as lack of vascular and organ rupture (summary by Reinstein et al., 2011).
Plasma clot retraction factor, deficiency of
MedGen UID:
376656
Concept ID:
C1849778
Disease or Syndrome
Cutis laxa, autosomal dominant
MedGen UID:
120630
Concept ID:
C0268350
Disease or Syndrome
Cutis laxa is a collection of disorders that are typified by loose and/or wrinkled skin that imparts a prematurely aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The skin lacks elastic recoil, in marked contrast to the hyperelasticity apparent in classical Ehlers-Danlos syndrome (see 130000). These properties are nearly always attributable to loss, fragmentation, or severe disorganization of dermal elastic fibers (summary by Davidson and Giro, 2002). Autosomal dominant congenital cutis laxa (ADCL) is genetically heterogeneous and shows clinical variability. The characteristic loose skin may be accompanied by gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema (summary by Graul-Neumann et al., 2008). Loose, inelastic skin is a clinical feature of many disorders, e.g., geroderma osteodysplasticum (GO; 231070) and Costello syndrome (218040). For a discussion of genetic heterogeneity of autosomal recessive cutis laxa, see ARCL1A (219100). Genetic Heterogeneity of Autosomal Dominant Cutis Laxa Also see ADCL2 (614434), caused by mutation in the FBLN5 gene (604580) on chromosome 14q32, and ADCL3 (616603), caused by mutation in the ALDH18A1 gene on chromosome 10q24.
Cutis laxa, autosomal recessive
MedGen UID:
78663
Concept ID:
C0268351
Disease or Syndrome
Ehlers-Danlos-like syndrome due to tenascin-X deficiency
MedGen UID:
336244
Concept ID:
C1848029
Disease or Syndrome
Tenascin-X deficiency leads to a clinically distinct form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, hypermobile joints, and tissue fragility. For further background information on EDS, see 130000.
Spondyloepimetaphyseal dysplasia with multiple dislocations
MedGen UID:
350960
Concept ID:
C1863732
Disease or Syndrome
Spondyloepimetaphyseal dysplasia with joint laxity type 2 (SEMDJL2) is characterized by short stature, distinctive midface retrusion, progressive knee malalignment (genu valgum and/or varum), generalized ligamentous laxity, and mild spinal deformity. Intellectual development is not impaired. Radiographic characteristics include significantly retarded epiphyseal ossification that evolves into epiphyseal dysplasia and precocious osteoarthritis, metaphyseal irregularities and vertical striations, constricted femoral neck, slender metacarpals and metatarsals, and mild thoracolumbar kyphosis or scoliosis with normal or mild platyspondyly (summary by Min et al., 2011). The most distinctive features for differential diagnosis of SEMDJL2 are the slender metacarpals and phalanges and the progressive degeneration of carpal bones; however, these 2 features are evident only in older children and young adults. The soft consistency of cartilage in the airways leads to laryngotracheomalacia with proneness to respiratory obstruction and inspiratory stridor in infancy and childhood (summary by Boyden et al., 2011).
Ehlers-Danlos syndrome type 7, autosomal recessive
MedGen UID:
397792
Concept ID:
C2700425
Disease or Syndrome
Dermatosparaxis (meaning 'tearing of skin') is an autosomal recessive disorder of connective tissue resulting from deficiency of procollagen peptidase, an enzyme that aids in the processing of type I procollagen. The disorder and the responsible biochemical defect was first observed in cattle (Lapiere et al., 1971). Lapiere and Nusgens (1993) reviewed the discovery of dermatosparaxis in cattle, the elucidation of the disorder, its occurrence in other animals, and the delayed recognition of the disorder in the human. Beighton et al. (1998) reported on a revised nosology of the Ehlers-Danlos syndromes, designated the Villefranche classification. Major and minor diagnostic criteria were defined for each type and complemented whenever possible with laboratory findings. Six main descriptive types were substituted for earlier types numbered with Roman numerals: classic type (EDS I and II), hypermobility type (EDS III), vascular type (EDS IV), kyphoscoliosis type (EDS VI), arthrochalasia type (EDS VIIA and VIIB), and dermatosparaxis type (EDS VIIC). Six other forms were listed, including a category of 'unspecified forms.'
Cutis laxa, autosomal recessive
MedGen UID:
784021
Concept ID:
C3665335
Disease or Syndrome

Recent clinical studies

Etiology

Sharma P, Henriksen CH, Zargar-Shoshtari K, Xin R, Poch MA, Pow-Sang JM, Sexton WJ, Spiess PE, Gilbert SM
J Urol 2016 Jan;195(1):47-52. Epub 2015 Jul 31 doi: 10.1016/j.juro.2015.07.095. [Epub ahead of print] PMID: 26235376Free PMC Article
Jiang J, Fernandes JC
J Orthop Surg Res 2015 Nov 10;10:173. doi: 10.1186/s13018-015-0316-3. [Epub ahead of print] PMID: 26555547Free PMC Article
Liang X, Han-Xin Z, Chang-E J, Chao W, Juan H, Guo-Quan G
Am Surg 2015 Jan;81(1):23-30. PMID: 25569053
Golomb MR, Smith JL
J Child Neurol 2014 Oct;29(10):NP101-4. Epub 2013 Oct 18 doi: 10.1177/0883073813506611. [Epub ahead of print] PMID: 24141273
Liu Y, Min D, Bolton T, Nubé V, Twigg SM, Yue DK, McLennan SV
Diabetes Care 2009 Jan;32(1):117-9. Epub 2008 Oct 3 doi: 10.2337/dc08-0763. [Epub ahead of print] PMID: 18835949Free PMC Article

Diagnosis

Koley M, Saha S, Arya JS, Choubey G, Ghosh S, Chattopadhyay R, Das KD, Ghosh A, Hait H, Mukherjee R, Banerjee T
J Evid Based Complementary Altern Med 2016 Jan;21(1):39-47. Epub 2015 Jul 7 doi: 10.1177/2156587215593656. [Epub ahead of print] PMID: 26156145
Demir MV, Tamer A, Cinemre H, Uslan I, Yaylaci S, Erkorkmaz U
Niger J Clin Pract 2015 Nov-Dec;18(6):757-61. doi: 10.4103/1119-3077.158145. PMID: 26289513
Liang X, Han-Xin Z, Chang-E J, Chao W, Juan H, Guo-Quan G
Am Surg 2015 Jan;81(1):23-30. PMID: 25569053
Welborn MC, Gottschalk H, Bindra R
J Pediatr Orthop 2015 Jul-Aug;35(5):e43-6. doi: 10.1097/BPO.0000000000000358. PMID: 25412072
Li Z, Guo S, Yao F, Zhang Y, Li T
J Diabetes Complications 2013 Jul-Aug;27(4):380-2. Epub 2013 Jan 26 doi: 10.1016/j.jdiacomp.2012.12.007. [Epub ahead of print] PMID: 23357650

Therapy

Stevens SM, O'Connell BP, Meyer TA
Curr Opin Otolaryngol Head Neck Surg 2015 Oct;23(5):341-7. doi: 10.1097/MOO.0000000000000194. PMID: 26339964
Choron RL, Chang S, Khan S, Villalobos MA, Zhang P, Carpenter JP, Tulenko TN, Liu Y
J Surg Res 2015 Jun 15;196(2):404-15. Epub 2015 Mar 18 doi: 10.1016/j.jss.2015.03.026. [Epub ahead of print] PMID: 25891676Free PMC Article
Liang X, Han-Xin Z, Chang-E J, Chao W, Juan H, Guo-Quan G
Am Surg 2015 Jan;81(1):23-30. PMID: 25569053
Golomb MR, Smith JL
J Child Neurol 2014 Oct;29(10):NP101-4. Epub 2013 Oct 18 doi: 10.1177/0883073813506611. [Epub ahead of print] PMID: 24141273
Liu Y, Min D, Bolton T, Nubé V, Twigg SM, Yue DK, McLennan SV
Diabetes Care 2009 Jan;32(1):117-9. Epub 2008 Oct 3 doi: 10.2337/dc08-0763. [Epub ahead of print] PMID: 18835949Free PMC Article

Prognosis

Liang X, Han-Xin Z, Chang-E J, Chao W, Juan H, Guo-Quan G
Am Surg 2015 Jan;81(1):23-30. PMID: 25569053
Letra A, Ghaneh G, Zhao M, Ray H Jr, Francisconi CF, Garlet GP, Silva RM
J Endod 2013 Sep;39(9):1141-6. doi: 10.1016/j.joen.2013.06.015. PMID: 23953287
Li Z, Guo S, Yao F, Zhang Y, Li T
J Diabetes Complications 2013 Jul-Aug;27(4):380-2. Epub 2013 Jan 26 doi: 10.1016/j.jdiacomp.2012.12.007. [Epub ahead of print] PMID: 23357650
Liu Y, Min D, Bolton T, Nubé V, Twigg SM, Yue DK, McLennan SV
Diabetes Care 2009 Jan;32(1):117-9. Epub 2008 Oct 3 doi: 10.2337/dc08-0763. [Epub ahead of print] PMID: 18835949Free PMC Article
Boissel P, Jamart J, Grumillier P, Grosdidier J
Am J Surg 1982 Mar;143(3):380-1. PMID: 7039381

Clinical prediction guides

Liang X, Han-Xin Z, Chang-E J, Chao W, Juan H, Guo-Quan G
Am Surg 2015 Jan;81(1):23-30. PMID: 25569053
Letra A, Ghaneh G, Zhao M, Ray H Jr, Francisconi CF, Garlet GP, Silva RM
J Endod 2013 Sep;39(9):1141-6. doi: 10.1016/j.joen.2013.06.015. PMID: 23953287
Li Z, Guo S, Yao F, Zhang Y, Li T
J Diabetes Complications 2013 Jul-Aug;27(4):380-2. Epub 2013 Jan 26 doi: 10.1016/j.jdiacomp.2012.12.007. [Epub ahead of print] PMID: 23357650
Liu Y, Min D, Bolton T, Nubé V, Twigg SM, Yue DK, McLennan SV
Diabetes Care 2009 Jan;32(1):117-9. Epub 2008 Oct 3 doi: 10.2337/dc08-0763. [Epub ahead of print] PMID: 18835949Free PMC Article
Boissel P, Jamart J, Grumillier P, Grosdidier J
Am J Surg 1982 Mar;143(3):380-1. PMID: 7039381

Recent systematic reviews

House SL
J Wound Ostomy Continence Nurs 2015 Jan-Feb;42(1):38-41. doi: 10.1097/WON.0000000000000080. PMID: 25549307
Khasraw M, Ameratunga MS, Grant R, Wheeler H, Pavlakis N
Cochrane Database Syst Rev 2014 Sep 22;(9):CD008218. doi: 10.1002/14651858.CD008218.pub3. PMID: 25242542
Breederveld RS, Tuinebreijer WE
Cochrane Database Syst Rev 2014 Sep 15;(9):CD008990. doi: 10.1002/14651858.CD008990.pub3. PMID: 25222766
Breederveld RS, Tuinebreijer WE
Cochrane Database Syst Rev 2012 Dec 12;12:CD008990. doi: 10.1002/14651858.CD008990.pub2. PMID: 23235668
Charoenkwan K, Chotirosniramit N, Rerkasem K
Cochrane Database Syst Rev 2012 Jun 13;(6):CD005987. doi: 10.1002/14651858.CD005987.pub2. PMID: 22696355

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