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Results: 16

1.

Difluoromethylornithine

a drug that is being studied in the treatment of cancer [from CHV]

MedGen UID:
88524
Concept ID:
C0086156
Pharmacologic Substance
2.

Sulindac

A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects. [from MeSH]

MedGen UID:
21401
Concept ID:
C0038792
Pharmacologic Substance
3.

Sporadic

MedGen UID:
64410
Concept ID:
C0205422
4.

Nu-Sulindac

MedGen UID:
327724
Concept ID:
C1564276
Pharmacologic Substance
5.

Copal

MedGen UID:
327723
Concept ID:
C1564274
Pharmacologic Substance
6.

Sulindal

MedGen UID:
289783
Concept ID:
C1564277
Pharmacologic Substance
7.

Kenalin

MedGen UID:
289782
Concept ID:
C1564275
Pharmacologic Substance
8.

Aclin

MedGen UID:
288922
Concept ID:
C1564273
Pharmacologic Substance
9.

Novo-Sundac

MedGen UID:
271529
Concept ID:
C1515045
Pharmacologic Substance
10.

Apo-Sulin

MedGen UID:
271143
Concept ID:
C1515040
Pharmacologic Substance
11.

MedGen UID:
182644
Concept ID:
C0939525
12.

MedGen UID:
149182
Concept ID:
C0733670
13.

MedGen UID:
148063
Concept ID:
C0733672
14.

MedGen UID:
108486
Concept ID:
C0591267
15.

Ornidyl

MedGen UID:
14516
Concept ID:
C0029275
Pharmacologic Substance
16.

Eflornithine

A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39754&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39754&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C226" NCI Thesaurus) [from PDQ]

MedGen UID:
1429
Concept ID:
C0002260
Pharmacologic Substance

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