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Familial multiple polyposis syndrome(FAP)

MedGen UID:
46010
Concept ID:
C0032580
Neoplastic Process
Synonyms: Adenomatous polyposis coli; Adenomatous polyposis of the colon; Familial adenomatous polyposis; Familial adenomatous polyposis of the colon; Familial intestinal polyposis; Familial multiple polyposis; Familial polyposis; Familial polyposis of the colon; FAP; Hereditary polyposis coli; Polyposis, adenomatous intestinal
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Sources: HPO, OMIM, Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: OMIM, Orphanet
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
Autosomal dominant inheritance
MedGen UID:
892334
Concept ID:
CN000007
Functional Concept
Source: HPO
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
Autosomal recessive inheritance (HPO, OMIM, Orphanet)
SNOMED CT: Adenomatous polyposis coli (70921007); Familial polyposis coli (70921007); Polyposis coli (70921007); Familial multiple polyposis syndrome (72900001); [M]Adenomatous polyposis coli (70921007); [M]Familial polyposis coli (70921007); Familial adenomatous polyposis (72900001); MYH-associated polyposis (423471004); MAP - MYH associated polyposis (423471004); FPC - Familial polyposis coli (72900001); Polyposis coli (72900001); FAP - Familial adenomatous polyposis (72900001); Adenomatous polyposis (72900001); Adenomatous polyposis coli (72900001); APC - Adenomatous polyposis coli (72900001); Familial polyposis coli (72900001)
 
OMIM®: 175100; 611731
Orphanet: ORPHA733

Definition

Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.In people with classic familial adenomatous polyposis, the number of polyps increases with age, and hundreds to thousands of polyps can develop in the colon. Also of particular significance are noncancerous growths called desmoid tumors. These fibrous tumors usually occur in the tissue covering the intestines and may be provoked by surgery to remove the colon. Desmoid tumors tend to recur after they are surgically removed. In both classic familial adenomatous polyposis and its attenuated variant, benign and malignant tumors are sometimes found in other places in the body, including the duodenum (a section of the small intestine), stomach, bones, skin, and other tissues. People who have colon polyps as well as growths outside the colon are sometimes described as having Gardner syndrome.A milder type of familial adenomatous polyposis, called autosomal recessive familial adenomatous polyposis, has also been identified. People with the autosomal recessive type of this disorder have fewer polyps than those with the classic type. Fewer than 100 polyps typically develop, rather than hundreds or thousands. The autosomal recessive type of this disorder is caused by mutations in a different gene than the classic and attenuated types of familial adenomatous polyposis.
[from GHR]

Clinical features

Small intestine carcinoid
MedGen UID:
356894
Concept ID:
C1868072
Finding
Papillary thyroid carcinoma
MedGen UID:
505394
Concept ID:
CN002618
Finding
The presence of a papillary adenocarcinoma of the thyroid gland.
Congenital hypertrophy of retinal pigment epithelium
MedGen UID:
83290
Concept ID:
C0339555
Finding
Sharply demarcated, congenital hyperpigmentation of thr retinal pigment epithelium.
Astrocytoma
MedGen UID:
438
Concept ID:
C0004114
Neoplastic Process
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Colon cancer
MedGen UID:
2839
Concept ID:
C0007102
Neoplastic Process
A primary or metastatic malignant neoplasm that affects the colon. Representative examples include carcinoma, lymphoma, and sarcoma.
Neoplasm of the nervous system
MedGen UID:
45046
Concept ID:
C0027766
Neoplastic Process
A tumor (abnormal growth of tissue) of the nervous system.
Odontogenic neoplasm
MedGen UID:
10426
Concept ID:
C0028880
Neoplastic Process
Neoplasms produced from tooth-forming tissues.
Odontoma
MedGen UID:
45181
Concept ID:
C0028882
Neoplastic Process
A mixed tumor of odontogenic origin, in which both the epithelial and mesenchymal cells exhibit complete differentiation, resulting in the formation of tooth structures. (Jablonski, Illustrated Dictionary of Dentistry, 1982)
Desmoid tumors
MedGen UID:
38187
Concept ID:
C0079218
Neoplastic Process
A childhood counterpart of abdominal or extra-abdominal desmoid tumors, characterized by firm subcutaneous nodules that grow rapidly in any part of the body but do not metastasize. The adult form of abdominal fibromatosis is FIBROMATOSIS, ABDOMINAL. (Stedman, 25th ed)
Hepatoblastoma
MedGen UID:
61644
Concept ID:
C0206624
Neoplastic Process
A kind of neoplasm of the liver that originates from immature liver precursor cells and macroscopically is composed of tissue resembling fetal or mature liver cells or bile ducts.
Adrenocortical adenoma
MedGen UID:
61654
Concept ID:
C0206667
Neoplastic Process
Adrenocortical adenomas are benign tumors of the adrenal cortex.
Gastric polyposis
MedGen UID:
68629
Concept ID:
C0236048
Disease or Syndrome
A polyp that arises from the stomach. This category includes neoplastic polyps (intestinal-type adenomatous polyps, gastric-type adenomas, and fundic gland polyps), and non-neoplastic polyps (hyperplastic polyps and hamartomatous polyps).
Duodenal polyposis
MedGen UID:
488924
Concept ID:
C0578477
Neoplastic Process
Presence of multiple polyps in the duodenum.
Multiple lipomas
MedGen UID:
677074
Concept ID:
C0745730
Finding
The presence of multiple lipomas (a type of benign tissue made of fatty tissue).
Intestinal polyposis
MedGen UID:
219797
Concept ID:
C1257915
Disease or Syndrome
The presence of multiple polyps in the intestine.
Fibroadenoma of the breast
MedGen UID:
488966
Concept ID:
C1328386
Neoplastic Process
A benign biphasic tumor of the breast with epithelial and stromal components.
Adenomatous colonic polyposis
MedGen UID:
358118
Concept ID:
C1868071
Finding
Presence of multiple adenomatous polyps in the colon.
Small intestine carcinoid
MedGen UID:
356894
Concept ID:
C1868072
Finding
Medulloblastoma
MedGen UID:
505388
Concept ID:
CN002609
Finding
A rapidly growing embryonic tumor arising in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle in children. More rarely, medulloblastoma arises in the cerebellum in adults.
Papillary thyroid carcinoma
MedGen UID:
505394
Concept ID:
CN002618
Finding
The presence of a papillary adenocarcinoma of the thyroid gland.
Duodenal adenocarcinoma
MedGen UID:
505977
Concept ID:
CN005894
Finding
A malignant epithelial tumor with a glandular organization that originates in the duodenum.
Sarcoma
MedGen UID:
506452
Concept ID:
CN117138
Finding
A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.
Osteoma
MedGen UID:
506455
Concept ID:
CN117142
Finding
Osteomas are bony growths found most commonly on the skull and mandible; however, they may occur in any bone of the body. Osteomas do not usually cause clinical problems and do not become malignant.
Neoplasm of the colon
MedGen UID:
451644
Concept ID:
CN117169
Finding
Colon cancer
MedGen UID:
2839
Concept ID:
C0007102
Neoplastic Process
A primary or metastatic malignant neoplasm that affects the colon. Representative examples include carcinoma, lymphoma, and sarcoma.
Desmoid tumors
MedGen UID:
38187
Concept ID:
C0079218
Neoplastic Process
A childhood counterpart of abdominal or extra-abdominal desmoid tumors, characterized by firm subcutaneous nodules that grow rapidly in any part of the body but do not metastasize. The adult form of abdominal fibromatosis is FIBROMATOSIS, ABDOMINAL. (Stedman, 25th ed)
Hepatoblastoma
MedGen UID:
61644
Concept ID:
C0206624
Neoplastic Process
A kind of neoplasm of the liver that originates from immature liver precursor cells and macroscopically is composed of tissue resembling fetal or mature liver cells or bile ducts.
Gastric polyposis
MedGen UID:
68629
Concept ID:
C0236048
Disease or Syndrome
A polyp that arises from the stomach. This category includes neoplastic polyps (intestinal-type adenomatous polyps, gastric-type adenomas, and fundic gland polyps), and non-neoplastic polyps (hyperplastic polyps and hamartomatous polyps).
Duodenal polyposis
MedGen UID:
488924
Concept ID:
C0578477
Neoplastic Process
Presence of multiple polyps in the duodenum.
Intestinal polyposis
MedGen UID:
219797
Concept ID:
C1257915
Disease or Syndrome
The presence of multiple polyps in the intestine.
Adenomatous colonic polyposis
MedGen UID:
358118
Concept ID:
C1868071
Finding
Presence of multiple adenomatous polyps in the colon.
Small intestine carcinoid
MedGen UID:
356894
Concept ID:
C1868072
Finding
Duodenal adenocarcinoma
MedGen UID:
505977
Concept ID:
CN005894
Finding
A malignant epithelial tumor with a glandular organization that originates in the duodenum.
Neoplasm of the colon
MedGen UID:
451644
Concept ID:
CN117169
Finding
Astrocytoma
MedGen UID:
438
Concept ID:
C0004114
Neoplastic Process
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Neoplasm of the nervous system
MedGen UID:
45046
Concept ID:
C0027766
Neoplastic Process
A tumor (abnormal growth of tissue) of the nervous system.
Small intestine carcinoid
MedGen UID:
356894
Concept ID:
C1868072
Finding
Medulloblastoma
MedGen UID:
505388
Concept ID:
CN002609
Finding
A rapidly growing embryonic tumor arising in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle in children. More rarely, medulloblastoma arises in the cerebellum in adults.
Colon cancer
MedGen UID:
2839
Concept ID:
C0007102
Neoplastic Process
A primary or metastatic malignant neoplasm that affects the colon. Representative examples include carcinoma, lymphoma, and sarcoma.
Desmoid tumors
MedGen UID:
38187
Concept ID:
C0079218
Neoplastic Process
A childhood counterpart of abdominal or extra-abdominal desmoid tumors, characterized by firm subcutaneous nodules that grow rapidly in any part of the body but do not metastasize. The adult form of abdominal fibromatosis is FIBROMATOSIS, ABDOMINAL. (Stedman, 25th ed)
Hepatoblastoma
MedGen UID:
61644
Concept ID:
C0206624
Neoplastic Process
A kind of neoplasm of the liver that originates from immature liver precursor cells and macroscopically is composed of tissue resembling fetal or mature liver cells or bile ducts.
Gastric polyposis
MedGen UID:
68629
Concept ID:
C0236048
Disease or Syndrome
A polyp that arises from the stomach. This category includes neoplastic polyps (intestinal-type adenomatous polyps, gastric-type adenomas, and fundic gland polyps), and non-neoplastic polyps (hyperplastic polyps and hamartomatous polyps).
Duodenal polyposis
MedGen UID:
488924
Concept ID:
C0578477
Neoplastic Process
Presence of multiple polyps in the duodenum.
Intestinal polyposis
MedGen UID:
219797
Concept ID:
C1257915
Disease or Syndrome
The presence of multiple polyps in the intestine.
Adenomatous colonic polyposis
MedGen UID:
358118
Concept ID:
C1868071
Finding
Presence of multiple adenomatous polyps in the colon.
Small intestine carcinoid
MedGen UID:
356894
Concept ID:
C1868072
Finding
Duodenal adenocarcinoma
MedGen UID:
505977
Concept ID:
CN005894
Finding
A malignant epithelial tumor with a glandular organization that originates in the duodenum.
Neoplasm of the colon
MedGen UID:
451644
Concept ID:
CN117169
Finding
Osteoma
MedGen UID:
506455
Concept ID:
CN117142
Finding
Osteomas are bony growths found most commonly on the skull and mandible; however, they may occur in any bone of the body. Osteomas do not usually cause clinical problems and do not become malignant.
Odontogenic neoplasm
MedGen UID:
10426
Concept ID:
C0028880
Neoplastic Process
Neoplasms produced from tooth-forming tissues.
Odontoma
MedGen UID:
45181
Concept ID:
C0028882
Neoplastic Process
A mixed tumor of odontogenic origin, in which both the epithelial and mesenchymal cells exhibit complete differentiation, resulting in the formation of tooth structures. (Jablonski, Illustrated Dictionary of Dentistry, 1982)
Teeth, supernumerary
MedGen UID:
21210
Concept ID:
C0040457
Congenital Abnormality
An extra tooth, erupted or unerupted, resembling or unlike the other teeth in the group to which it belongs. Its presence may cause malposition of adjacent teeth or prevent their eruption.
Unerupted tooth
MedGen UID:
11856
Concept ID:
C0040458
Finding
The presence of one or more embedded tooth germs which have failed to erupt.
Carious teeth
MedGen UID:
401327
Concept ID:
C1867882
Finding
Keloid formation
MedGen UID:
7197
Concept ID:
C0022548
Acquired Abnormality
Keloid is a dermal fibroproliferative growth caused by pathologic wound healing following skin injury. Keloid is defined as a scar growing continuously and invasively beyond the confines of the original wound and is characterized by excessive fibroblast proliferation and deposition of extracellular matrix and collagen fibers. Local tissue factors, especially wound tension or infection, and endocrine factors are known to be involved in keloid formation. However, the fact that the incidence of keloid is higher in darker-skinned individuals suggests that genetic factors also play an important role (summary by Nakashima et al., 2010).
Multiple lipomas
MedGen UID:
677074
Concept ID:
C0745730
Finding
The presence of multiple lipomas (a type of benign tissue made of fatty tissue).
Epidermoid cysts
MedGen UID:
41829
Concept ID:
C0014511
Anatomical Abnormality
The presence of one or more cysts of the skin.
Keloid formation
MedGen UID:
7197
Concept ID:
C0022548
Acquired Abnormality
Keloid is a dermal fibroproliferative growth caused by pathologic wound healing following skin injury. Keloid is defined as a scar growing continuously and invasively beyond the confines of the original wound and is characterized by excessive fibroblast proliferation and deposition of extracellular matrix and collagen fibers. Local tissue factors, especially wound tension or infection, and endocrine factors are known to be involved in keloid formation. However, the fact that the incidence of keloid is higher in darker-skinned individuals suggests that genetic factors also play an important role (summary by Nakashima et al., 2010).
Irregular hyperpigmentation
MedGen UID:
349760
Concept ID:
C1860236
Finding
Adrenocortical adenoma
MedGen UID:
61654
Concept ID:
C0206667
Neoplastic Process
Adrenocortical adenomas are benign tumors of the adrenal cortex.
Small intestine carcinoid
MedGen UID:
356894
Concept ID:
C1868072
Finding
Papillary thyroid carcinoma
MedGen UID:
505394
Concept ID:
CN002618
Finding
The presence of a papillary adenocarcinoma of the thyroid gland.
Fibroadenoma of the breast
MedGen UID:
488966
Concept ID:
C1328386
Neoplastic Process
A benign biphasic tumor of the breast with epithelial and stromal components.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFamilial multiple polyposis syndrome
Follow this link to review classifications for Familial multiple polyposis syndrome in Orphanet.

Professional guidelines

PubMed

Hampel H, Bennett RL, Buchanan A, Pearlman R, Wiesner GL; Guideline Development Group, American College of Medical Genetics and Genomics Professional Practice and Guidelines Committee and National Society of Genetic Counselors Practice Guidelines Committee
Genet Med 2015 Jan;17(1):70-87. Epub 2014 Nov 13 doi: 10.1038/gim.2014.147. [Epub ahead of print] PMID: 25394175
Vasen HF, Möslein G, Alonso A, Aretz S, Bernstein I, Bertario L, Blanco I, Bülow S, Burn J, Capella G, Colas C, Engel C, Frayling I, Friedl W, Hes FJ, Hodgson S, Järvinen H, Mecklin JP, Møller P, Myrhøi T, Nagengast FM, Parc Y, Phillips R, Clark SK, de Leon MP, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Tejpar S, Thomas HJ, Wijnen J
Gut 2008 May;57(5):704-13. Epub 2008 Jan 14 doi: 10.1136/gut.2007.136127. [Epub ahead of print] PMID: 18194984

Recent clinical studies

Etiology

Selmin OI, Fang C, Lyon AM, Doetschman TC, Thompson PA, Martinez JD, Smith JW, Lance PM, Romagnolo DF
J Nutr 2016 Feb;146(2):236-42. Epub 2015 Nov 25 doi: 10.3945/jn.115.216580. [Epub ahead of print] PMID: 26609171
Jiang SS, Li JJ, Li Y, He LJ, Wang QJ, Weng DS, Pan K, Liu Q, Zhao JJ, Pan QZ, Zhang XF, Tang Y, Chen CL, Zhang HX, Xu GL, Zeng YX, Xia JC
Oncotarget 2015 Sep 29;6(29):27267-74. doi: 10.18632/oncotarget.4776. PMID: 26311738Free PMC Article
Feng X, Milas M, O'Malley M, LaGuardia L, Berber E, Jin J, Metzger R, Mitchell J, Shin J, Burke CA, Kalady M, Church J, Siperstein A
Thyroid 2015 Mar;25(3):325-32. Epub 2015 Feb 9 doi: 10.1089/thy.2014.0107. [Epub ahead of print] PMID: 25585202
Campos FG
World J Gastroenterol 2014 Nov 28;20(44):16620-9. doi: 10.3748/wjg.v20.i44.16620. PMID: 25469031Free PMC Article
Estrella JS, Taggart MW, Rashid A, Abraham SC
Hum Pathol 2014 Oct;45(10):2051-8. Epub 2014 Jul 24 doi: 10.1016/j.humpath.2014.07.001. [Epub ahead of print] PMID: 25149552

Diagnosis

Jiang SS, Li JJ, Li Y, He LJ, Wang QJ, Weng DS, Pan K, Liu Q, Zhao JJ, Pan QZ, Zhang XF, Tang Y, Chen CL, Zhang HX, Xu GL, Zeng YX, Xia JC
Oncotarget 2015 Sep 29;6(29):27267-74. doi: 10.18632/oncotarget.4776. PMID: 26311738Free PMC Article
Li FF, Liu Z, Yan P, Shao X, Deng X, Sam C, Chen YG, Xu YP, Wang XS, Wang GY, Liu SL
Int J Mol Med 2015 Oct;36(4):1049-56. Epub 2015 Aug 5 doi: 10.3892/ijmm.2015.2303. [Epub ahead of print] PMID: 26252958
Feng X, Milas M, O'Malley M, LaGuardia L, Berber E, Jin J, Metzger R, Mitchell J, Shin J, Burke CA, Kalady M, Church J, Siperstein A
Thyroid 2015 Mar;25(3):325-32. Epub 2015 Feb 9 doi: 10.1089/thy.2014.0107. [Epub ahead of print] PMID: 25585202
Campos FG
World J Gastroenterol 2014 Nov 28;20(44):16620-9. doi: 10.3748/wjg.v20.i44.16620. PMID: 25469031Free PMC Article
Cohen S, Gorodnichenco A, Weiss B, Lerner A, Ben-Tov A, Yaron A, Reif S
Eur J Gastroenterol Hepatol 2014 Sep;26(9):972-7. doi: 10.1097/MEG.0000000000000143. PMID: 24999926

Therapy

Narayan S, Sharma R
Life Sci 2015 Oct 15;139:145-52. Epub 2015 Sep 1 doi: 10.1016/j.lfs.2015.08.019. [Epub ahead of print] PMID: 26334567Free PMC Article
Li FF, Liu Z, Yan P, Shao X, Deng X, Sam C, Chen YG, Xu YP, Wang XS, Wang GY, Liu SL
Int J Mol Med 2015 Oct;36(4):1049-56. Epub 2015 Aug 5 doi: 10.3892/ijmm.2015.2303. [Epub ahead of print] PMID: 26252958
Ganschow P, Treiber I, Hinz U, Leowardi C, Büchler MW, Kadmon M
Langenbecks Arch Surg 2015 Feb;400(2):213-9. Epub 2015 Jan 14 doi: 10.1007/s00423-014-1263-x. [Epub ahead of print] PMID: 25586093
Hazewinkel Y, Koornstra JJ, Boparai KS, van Os TA, Tytgat KM, Van Eeden S, Fockens P, Dekker E
J Clin Gastroenterol 2015 May-Jun;49(5):407-12. doi: 10.1097/MCG.0000000000000103. PMID: 24583756
Campos FG
World J Gastroenterol 2014 Nov 28;20(44):16620-9. doi: 10.3748/wjg.v20.i44.16620. PMID: 25469031Free PMC Article

Prognosis

Ponti G, Tomasi A, Manfredini M, Pellacani G
Gene 2016 May 10;582(1):23-32. Epub 2016 Feb 3 doi: 10.1016/j.gene.2016.01.053. [Epub ahead of print] PMID: 26850131
Miao CG, Shi WJ, Xiong YY, Yu H, Zhang XL, Qin MS, Du CL, Song TW, Zhang B, Li J
Immunol Lett 2015 Jul;166(1):45-54. Epub 2015 May 28 doi: 10.1016/j.imlet.2015.05.011. [Epub ahead of print] PMID: 26028359
Abdelmaksoud-Damak R, Miladi-Abdennadher I, Triki M, Khabir A, Charfi S, Ayadi L, Frikha M, Sellami-Boudawara T, Mokdad-Gargouri R
Arch Med Res 2015 Jan;46(1):54-62. Epub 2015 Feb 3 doi: 10.1016/j.arcmed.2015.01.001. [Epub ahead of print] PMID: 25660336
Ganschow P, Treiber I, Hinz U, Leowardi C, Büchler MW, Kadmon M
Langenbecks Arch Surg 2015 Feb;400(2):213-9. Epub 2015 Jan 14 doi: 10.1007/s00423-014-1263-x. [Epub ahead of print] PMID: 25586093
Das D, Preet R, Mohapatra P, Satapathy SR, Siddharth S, Tamir T, Jain V, Bharatam PV, Wyatt MD, Kundu CN
DNA Repair (Amst) 2014 Dec;24:15-25. doi: 10.1016/j.dnarep.2014.10.006. PMID: 25460919Free PMC Article

Clinical prediction guides

Ponti G, Tomasi A, Manfredini M, Pellacani G
Gene 2016 May 10;582(1):23-32. Epub 2016 Feb 3 doi: 10.1016/j.gene.2016.01.053. [Epub ahead of print] PMID: 26850131
Miao CG, Shi WJ, Xiong YY, Yu H, Zhang XL, Qin MS, Du CL, Song TW, Zhang B, Li J
Immunol Lett 2015 Jul;166(1):45-54. Epub 2015 May 28 doi: 10.1016/j.imlet.2015.05.011. [Epub ahead of print] PMID: 26028359
Feng X, Milas M, O'Malley M, LaGuardia L, Berber E, Jin J, Metzger R, Mitchell J, Shin J, Burke CA, Kalady M, Church J, Siperstein A
Thyroid 2015 Mar;25(3):325-32. Epub 2015 Feb 9 doi: 10.1089/thy.2014.0107. [Epub ahead of print] PMID: 25585202
Hazewinkel Y, Koornstra JJ, Boparai KS, van Os TA, Tytgat KM, Van Eeden S, Fockens P, Dekker E
J Clin Gastroenterol 2015 May-Jun;49(5):407-12. doi: 10.1097/MCG.0000000000000103. PMID: 24583756
Estrella JS, Taggart MW, Rashid A, Abraham SC
Hum Pathol 2014 Oct;45(10):2051-8. Epub 2014 Jul 24 doi: 10.1016/j.humpath.2014.07.001. [Epub ahead of print] PMID: 25149552

Recent systematic reviews

Slowik V, Attard T, Dai H, Shah R, Septer S
BMC Gastroenterol 2015 Jul 16;15:84. doi: 10.1186/s12876-015-0306-2. [Epub ahead of print] PMID: 26179480Free PMC Article
Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW; American College of Gastroenterology
Am J Gastroenterol 2015 Feb;110(2):223-62; quiz 263. Epub 2015 Feb 3 doi: 10.1038/ajg.2014.435. [Epub ahead of print] PMID: 25645574Free PMC Article
Stoffel EM, Mangu PB, Gruber SB, Hamilton SR, Kalady MF, Lau MW, Lu KH, Roach N, Limburg PJ; American Society of Clinical Oncology; European Society of Clinical Oncology
J Clin Oncol 2015 Jan 10;33(2):209-17. Epub 2014 Dec 1 doi: 10.1200/JCO.2014.58.1322. [Epub ahead of print] PMID: 25452455
Mennigen R, Sewald W, Senninger N, Rijcken E
J Gastrointest Surg 2014 Dec;18(12):2192-200. Epub 2014 Sep 18 doi: 10.1007/s11605-014-2660-8. [Epub ahead of print] PMID: 25231081
Barrow P, Khan M, Lalloo F, Evans DG, Hill J
Br J Surg 2013 Dec;100(13):1719-31. doi: 10.1002/bjs.9316. PMID: 24227356

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