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enzastaurin

MedGen UID:
231213
Concept ID:
C1327830
Pharmacologic Substance
Synonyms: Enzastaurin; ENZASTAURIN
 

Definition

A substance being studied in the treatment of certain types of cancer, including non-Hodgkin lymphoma, breast, colon, lung, ovarian, and prostate. Enzastaurin blocks certain cell signaling pathways, and may prevent the growth of new blood vessels that tumors need to grow. It is a type of serine threonine kinase inhibitor and a type of antiangiogenesis agent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGenzastaurin

Recent clinical studies

Etiology

Schwartzberg L, Hermann R, Flinn I, Flora D, Hsi ED, Hamid O, Shi P, Lin BK, Myrand SP, Nguyen TS, Dreyling M
Br J Haematol 2014 Jul;166(1):91-7. Epub 2014 Mar 27 doi: 10.1111/bjh.12853. [Epub ahead of print] PMID: 24673609
Wick W, Steinbach JP, Platten M, Hartmann C, Wenz F, von Deimling A, Shei P, Moreau-Donnet V, Stoffregen C, Combs SE
Neuro Oncol 2013 Oct;15(10):1405-12. Epub 2013 Aug 1 doi: 10.1093/neuonc/not100. [Epub ahead of print] PMID: 23911595Free PMC Article
Vergote IB, Chekerov R, Amant F, Harter P, Casado A, Emerich J, Bauknecht T, Mansouri K, Myrand SP, Nguyen TS, Shi P, Sehouli J
J Clin Oncol 2013 Sep 1;31(25):3127-32. Epub 2013 Jul 29 doi: 10.1200/JCO.2012.44.9116. [Epub ahead of print] PMID: 23897968
Gray JE, Altiok S, Alexandrow MG, Walsh FW, Chen J, Schell MJ, Tai DF, Bepler G
Cancer 2013 Mar 1;119(5):1023-32. Epub 2012 Oct 12 doi: 10.1002/cncr.27836. [Epub ahead of print] PMID: 23065656Free PMC Article
Schmidinger M, Szczylik C, Sternberg CN, Kania M, Kelly CS, Decker R, Hamid O, Faelker T, Escudier B
Am J Clin Oncol 2012 Oct;35(5):493-7. doi: 10.1097/COC.0b013e31821cfc41. PMID: 21654314

Diagnosis

Vergote I
Expert Opin Investig Drugs 2014 May;23(5):579-98. Epub 2014 Mar 22 doi: 10.1517/13543784.2014.900542. [Epub ahead of print] PMID: 24654681
Wick W, Steinbach JP, Platten M, Hartmann C, Wenz F, von Deimling A, Shei P, Moreau-Donnet V, Stoffregen C, Combs SE
Neuro Oncol 2013 Oct;15(10):1405-12. Epub 2013 Aug 1 doi: 10.1093/neuonc/not100. [Epub ahead of print] PMID: 23911595Free PMC Article
Vergote IB, Chekerov R, Amant F, Harter P, Casado A, Emerich J, Bauknecht T, Mansouri K, Myrand SP, Nguyen TS, Shi P, Sehouli J
J Clin Oncol 2013 Sep 1;31(25):3127-32. Epub 2013 Jul 29 doi: 10.1200/JCO.2012.44.9116. [Epub ahead of print] PMID: 23897968
Shimokawa T, Seike M, Soeno C, Uesaka H, Miyanaga A, Mizutani H, Kitamura K, Minegishi Y, Noro R, Okano T, Yoshimura A, Gemma A
Br J Cancer 2012 Feb 28;106(5):867-75. Epub 2012 Feb 14 doi: 10.1038/bjc.2012.7. [Epub ahead of print] PMID: 22333600Free PMC Article
Wu X, Zhu M, Fletcher JA, Giobbie-Hurder A, Hodi FS
PLoS One 2012;7(1):e29622. Epub 2012 Jan 12 doi: 10.1371/journal.pone.0029622. PMID: 22253748Free PMC Article

Therapy

Schwartzberg L, Hermann R, Flinn I, Flora D, Hsi ED, Hamid O, Shi P, Lin BK, Myrand SP, Nguyen TS, Dreyling M
Br J Haematol 2014 Jul;166(1):91-7. Epub 2014 Mar 27 doi: 10.1111/bjh.12853. [Epub ahead of print] PMID: 24673609
Jourdan E, Leblond V, Maisonneuve H, Benhadji KA, Hossain AM, Nguyen TS, Wooldridge JE, Moreau P
Leuk Lymphoma 2014 Sep;55(9):2013-7. Epub 2014 May 2 doi: 10.3109/10428194.2013.861066. [Epub ahead of print] PMID: 24180331
Wick W, Steinbach JP, Platten M, Hartmann C, Wenz F, von Deimling A, Shei P, Moreau-Donnet V, Stoffregen C, Combs SE
Neuro Oncol 2013 Oct;15(10):1405-12. Epub 2013 Aug 1 doi: 10.1093/neuonc/not100. [Epub ahead of print] PMID: 23911595Free PMC Article
Romano S, Nappo G, Calì G, Wang SY, Staibano S, D'Angelillo A, Ilardi G, Sorrentino A, Di Pace AL, Siano M, Bisogni R, Romano MF
Pigment Cell Melanoma Res 2013 Nov;26(6):900-11. Epub 2013 Aug 7 doi: 10.1111/pcmr.12144. [Epub ahead of print] PMID: 23866034
Dreicer R, Garcia J, Rini B, Vogelzang N, Srinivas S, Somer B, Shi P, Kania M, Raghavan D
Invest New Drugs 2013 Aug;31(4):1044-50. Epub 2013 Feb 24 doi: 10.1007/s10637-013-9940-0. [Epub ahead of print] PMID: 23435622

Prognosis

Wick W, Steinbach JP, Platten M, Hartmann C, Wenz F, von Deimling A, Shei P, Moreau-Donnet V, Stoffregen C, Combs SE
Neuro Oncol 2013 Oct;15(10):1405-12. Epub 2013 Aug 1 doi: 10.1093/neuonc/not100. [Epub ahead of print] PMID: 23911595Free PMC Article
Shimokawa T, Seike M, Soeno C, Uesaka H, Miyanaga A, Mizutani H, Kitamura K, Minegishi Y, Noro R, Okano T, Yoshimura A, Gemma A
Br J Cancer 2012 Feb 28;106(5):867-75. Epub 2012 Feb 14 doi: 10.1038/bjc.2012.7. [Epub ahead of print] PMID: 22333600Free PMC Article
Schmidinger M, Szczylik C, Sternberg CN, Kania M, Kelly CS, Decker R, Hamid O, Faelker T, Escudier B
Am J Clin Oncol 2012 Oct;35(5):493-7. doi: 10.1097/COC.0b013e31821cfc41. PMID: 21654314
Usha L, Sill MW, Darcy KM, Benbrook DM, Hurteau JA, Michelin DP, Mannel RS, Hanjani P, De Geest K, Godwin AK
Gynecol Oncol 2011 Jun 1;121(3):455-61. Epub 2011 Mar 17 doi: 10.1016/j.ygyno.2011.02.013. [Epub ahead of print] PMID: 21414654Free PMC Article
Ruvolo PP, Zhou L, Watt JC, Ruvolo VR, Burks JK, Jiffar T, Kornblau S, Konopleva M, Andreeff M
J Cell Biochem 2011 Jun;112(6):1696-707. doi: 10.1002/jcb.23090. PMID: 21360576Free PMC Article

Clinical prediction guides

Jourdan E, Leblond V, Maisonneuve H, Benhadji KA, Hossain AM, Nguyen TS, Wooldridge JE, Moreau P
Leuk Lymphoma 2014 Sep;55(9):2013-7. Epub 2014 May 2 doi: 10.3109/10428194.2013.861066. [Epub ahead of print] PMID: 24180331
Grønberg BH, Ciuleanu T, Fløtten Ø, Knuuttila A, Abel E, Langer SW, Krejcy K, Liepa AM, Munoz M, Hahka-Kemppinen M, Sundstrøm S
Lung Cancer 2012 Oct;78(1):63-9. Epub 2012 Aug 20 doi: 10.1016/j.lungcan.2012.07.007. [Epub ahead of print] PMID: 22917813
Ghobrial IM, Moreau P, Harris B, Poon T, Jourdan E, Maisonneuve H, Benhadji KA, Hossain AM, Nguyen TS, Wooldridge JE, Leblond V
Clin Cancer Res 2012 Sep 15;18(18):5043-50. Epub 2012 Aug 9 doi: 10.1158/1078-0432.CCR-12-0181. [Epub ahead of print] PMID: 22879385
Shimokawa T, Seike M, Soeno C, Uesaka H, Miyanaga A, Mizutani H, Kitamura K, Minegishi Y, Noro R, Okano T, Yoshimura A, Gemma A
Br J Cancer 2012 Feb 28;106(5):867-75. Epub 2012 Feb 14 doi: 10.1038/bjc.2012.7. [Epub ahead of print] PMID: 22333600Free PMC Article
Rovedo MA, Krett NL, Rosen ST
J Invest Dermatol 2011 Jul;131(7):1442-9. Epub 2011 Apr 7 doi: 10.1038/jid.2011.70. [Epub ahead of print] PMID: 21471986Free PMC Article

Recent systematic reviews

Ysebaert L, Morschhauser F
Expert Opin Investig Drugs 2011 Aug;20(8):1167-74. Epub 2011 Jun 5 doi: 10.1517/13543784.2011.590130. [Epub ahead of print] PMID: 21639821
Minniti G, Muni R, Lanzetta G, Marchetti P, Enrici RM
Anticancer Res 2009 Dec;29(12):5171-84. PMID: 20044633
Chen YB, LaCasce AS
Expert Opin Investig Drugs 2008 Jun;17(6):939-44. doi: 10.1517/13543784.17.6.939 . PMID: 18491994

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