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Results: 1 to 20 of 35

1.

Thrombophilia

Prothrombin-related thrombophilia is characterized by venous thromboembolism (VTE) manifest most commonly in adults as deep-vein thrombosis (DVT) in the legs or pulmonary embolism. The clinical expression of prothrombin-related thrombophilia is variable; many individuals heterozygous or homozygous for the 20210G>A (G20210A or c.*97G>A) allele in F2 never develop thrombosis, and while most heterozygotes who develop thrombotic complications remain asymptomatic until adulthood, some have recurrent thromboembolism before age 30 years. The relative risk for DVT in adults heterozygous for the 20210G>A allele is two- to fivefold increased; in children, the relative risk for thrombosis is three- to fourfold increased. 20210G>A heterozygosity has at most a modest effect on recurrence risk after a first episode. Although prothrombin-related thrombophilia may increase the risk for pregnancy loss, its association with preeclampsia and other complications of pregnancy such as intrauterine growth restriction and placental abruption remains controversial. Factors that predispose to thrombosis in prothrombin-related thrombophilia include: the number of 20210G>A alleles; presence of coexisting genetic abnormalities including factor V Leiden; and acquired thrombophilic disorders (e.g., antiphospholipid antibodies). Circumstantial risk factors for thrombosis include pregnancy and oral contraceptive use. Some evidence suggests that the risk for VTE in 20210G>A heterozygotes increases after travel. [from GeneReviews]

MedGen UID:
98306
Concept ID:
C0398623
Disease or Syndrome
2.

Hypercoagulability

MedGen UID:
463623
Concept ID:
C3160733
Finding
3.

Venous Thromboembolism

Occlusion of the lumen of a vein by a thrombus that has migrated from a distal site via the blood stream. [from NCI]

MedGen UID:
348285
Concept ID:
C1861172
Pathologic Function
4.

sequelae aspects

MedGen UID:
116734
Concept ID:
C0243088
Pathologic Function
5.

Thromboembolism

A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream. [from NCI]

MedGen UID:
21532
Concept ID:
C0040038
Disease or Syndrome
6.

Thrombosis

The formation or presence of a thrombus (blood clot) inside a blood vessel. [from NCI]

MedGen UID:
21160
Concept ID:
C0040053
Pathologic Function
7.

Syndrome

A set of symptoms or conditions that occur together and suggest the presence of a certain disease or an increased chance of developing the disease. [from NCI]

MedGen UID:
11688
Concept ID:
C0039082
Disease or Syndrome
8.

Acquired thrombophilia

MedGen UID:
749574
Concept ID:
C2585317
Disease or Syndrome
9.

Stasis

a state in which the normal flow of a body liquid stops [from CHV]

MedGen UID:
568892
Concept ID:
C0333138
Pathologic Function
10.

Thromboembolism

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
505000
Concept ID:
CN001725
Finding
11.

Postthrombotic Syndrome

A condition caused by one or more episodes of DEEP VEIN THROMBOSIS, usually the blood clots are lodged in the legs. Clinical features include EDEMA; PAIN; aching; heaviness; and MUSCLE CRAMP in the leg. When severe leg swelling leads to skin breakdown, it is called venous STASIS ULCER. [from MeSH]

MedGen UID:
82924
Concept ID:
C0277919
Disease or Syndrome
12.

Hemorrhage

Bleeding is the loss of blood. It can happen inside or outside the body. Bleeding can be a reaction to a cut or other wound. It can also result from an injury to internal organs. There are many situations in which you might bleed. A bruise is bleeding under the skin. Some strokes are caused by bleeding in the brain. Other bleeding, such as gastrointestinal bleeding, coughing up blood, or vaginal bleeding, can be a symptom of a disease. Normally, when you bleed, your blood forms clots to stop the bleeding. Severe bleeding may require first aid or a trip to the emergency room. If you have a bleeding disorder, your blood does not form clots normally.  [from MedlinePlus]

MedGen UID:
5503
Concept ID:
C0019080
Pathologic Function
13.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
14.

vessel (polysaccharide)

MedGen UID:
56099
Concept ID:
C0148346
Pharmacologic Substance
15.

Thrombus

MedGen UID:
43439
Concept ID:
C0087086
Pathologic Function
16.

Embolism and Thrombosis

A collective term for pathological conditions which are caused by the formation of a blood clot (THROMBUS) in a blood vessel, or by blocking of a blood vessel with an EMBOLUS, undissolved materials in the blood stream. [from MeSH]

MedGen UID:
43147
Concept ID:
C0085307
Disease or Syndrome
17.

Vascular disorder

The vascular system is the body's network of blood vessels. It includes the arteries, veins and capillaries that carry blood to and from the heart. Problems of the vascular system are common and can be serious. Arteries can become thick and stiff, a problem called atherosclerosis. Blood clots can clog vessels and block blood flow to the heart or brain. Weakened blood vessels can burst, causing bleeding inside the body. . You are more likely to have vascular disease as you get older. Other factors that make vascular disease more likely include: - Family history of vascular or heart diseases. - Pregnancy. - Illness or injury . - Long periods of sitting or standing still. - Any condition that affects the heart and blood vessels, such as diabetes or high cholesterol . - Smoking . - Obesity . Losing weight, eating healthy foods, being active and not smoking can help vascular disease. Other treatments include medicines and surgery.  [from MedlinePlus]

MedGen UID:
22621
Concept ID:
C0042373
Disease or Syndrome
18.

Serine Proteinase Inhibitors

Compounds that inhibit serine endopeptidases. Serine proteinase inhibitors can be either exogenous or endogenous. Endogenous moieties occur naturally; however, exogenous inhibitors can be introduced to provide therapeutic benefit, such as antiretroviral or antiviral pharmaceuticals. [from NCI]

MedGen UID:
20708
Concept ID:
C0036733
Pharmacologic Substance
19.

Coagulation factor II

A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia. [from MeSH]

MedGen UID:
19527
Concept ID:
C0033706
Pharmacologic Substance
20.

Protease Inhibitor

A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies of itself (for example, AIDS virus protease inhibitors), and some can prevent cancer cells from spreading. [from NCI]

MedGen UID:
18701
Concept ID:
C0033607
Pharmacologic Substance

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