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Aging

MedGen UID:
1376
Concept ID:
C0001811
Organism Function
Synonyms: AGING
SNOMED CT: Aging (248280005)
 
OMIM®: 502000

Definition

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]

Recent clinical studies

Etiology

Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE
Proc Natl Acad Sci U S A 2015 Jul 28;112(30):E4104-10. Epub 2015 Jul 6 doi: 10.1073/pnas.1506264112. [Epub ahead of print] PMID: 26150497Free PMC Article
Resnick B, Klinedinst NJ, Yerges-Armstrong L, Choi EY, Dorsey SG
J Aging Health 2015 Sep;27(6):1084-104. Epub 2015 Mar 27 doi: 10.1177/0898264315577586. [Epub ahead of print] PMID: 25818147
Pruchno RA, Wilson-Genderson M
J Gerontol B Psychol Sci Soc Sci 2015 Nov;70(6):850-9. Epub 2014 May 13 doi: 10.1093/geronb/gbu046. [Epub ahead of print] PMID: 24829305
Grammatikakis I, Panda AC, Abdelmohsen K, Gorospe M
Aging (Albany NY) 2014 Dec;6(12):992-1009. PMID: 25543668Free PMC Article
Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, Howard BV
Aging (Albany NY) 2014 Mar;6(3):176-86. PMID: 24799415Free PMC Article

Diagnosis

Franzon K, Zethelius B, Cederholm T, Kilander L
J Am Geriatr Soc 2015 May;63(5):877-85. Epub 2015 Apr 27 doi: 10.1111/jgs.13352. [Epub ahead of print] PMID: 25919442
Sanchis-Gomar F, Pareja-Galeano H, Santos-Lozano A, Garatachea N, Fiuza-Luces C, Venturini L, Ricevuti G, Lucia A, Emanuele E
Age (Dordr) 2015 Jun;37(3):9776. Epub 2015 Apr 25 doi: 10.1007/s11357-015-9776-y. [Epub ahead of print] PMID: 25911468Free PMC Article
Calabrese V, Dattilo S, Petralia A, Parenti R, Pennisi M, Koverech G, Calabrese V, Graziano A, Monte I, Maiolino L, Ferreri T, Calabrese EJ
Free Radic Res 2015 May;49(5):511-24. Epub 2015 Mar 31 doi: 10.3109/10715762.2015.1020799. [Epub ahead of print] PMID: 25824967
Cunningham GM, Roman MG, Flores LC, Hubbard GB, Salmon AB, Zhang Y, Gelfond J, Ikeno Y
Arch Biochem Biophys 2015 Jun 15;576:32-8. Epub 2015 Feb 26 doi: 10.1016/j.abb.2015.02.025. [Epub ahead of print] PMID: 25726727
Glaab E, Schneider R
Neurobiol Dis 2015 Feb;74:1-13. Epub 2014 Nov 12 doi: 10.1016/j.nbd.2014.11.002. [Epub ahead of print] PMID: 25447234

Therapy

Assmann KE, Andreeva VA, Jeandel C, Hercberg S, Galan P, Kesse-Guyot E
Am J Epidemiol 2015 Oct 15;182(8):694-704. Epub 2015 Sep 15 doi: 10.1093/aje/kwv105. [Epub ahead of print] PMID: 26374140
Ahlqvist KJ, Suomalainen A, Hämäläinen RH
Biochim Biophys Acta 2015 Nov;1847(11):1380-6. Epub 2015 May 23 doi: 10.1016/j.bbabio.2015.05.014. [Epub ahead of print] PMID: 26014347
Tyrovolas S, Haro JM, Mariolis A, Piscopo S, Valacchi G, Makri K, Zeimbekis A, Tyrovola D, Bountziouka V, Gotsis E, Metallinos G, Tur JA, Matalas A, Lionis C, Polychronopoulos E, Panagiotakos D
J Aging Health 2015 Dec;27(8):1375-91. Epub 2015 Apr 22 doi: 10.1177/0898264315583053. [Epub ahead of print] PMID: 25903982
Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC
Aging (Albany NY) 2015 Jan;7(1):38-52. PMID: 25596819Free PMC Article
Seetharaman S, Andel R, McEvoy C, Dahl Aslan AK, Finkel D, Pedersen NL
J Gerontol A Biol Sci Med Sci 2015 Apr;70(4):471-9. Epub 2014 Aug 22 doi: 10.1093/gerona/glu135. [Epub ahead of print] PMID: 25149688Free PMC Article

Prognosis

Kaeberlein M, Rabinovitch PS, Martin GM
Science 2015 Dec 4;350(6265):1191-3. doi: 10.1126/science.aad3267. PMID: 26785476
Franzon K, Zethelius B, Cederholm T, Kilander L
J Am Geriatr Soc 2015 May;63(5):877-85. Epub 2015 Apr 27 doi: 10.1111/jgs.13352. [Epub ahead of print] PMID: 25919442
Calabrese V, Dattilo S, Petralia A, Parenti R, Pennisi M, Koverech G, Calabrese V, Graziano A, Monte I, Maiolino L, Ferreri T, Calabrese EJ
Free Radic Res 2015 May;49(5):511-24. Epub 2015 Mar 31 doi: 10.3109/10715762.2015.1020799. [Epub ahead of print] PMID: 25824967
Seetharaman S, Andel R, McEvoy C, Dahl Aslan AK, Finkel D, Pedersen NL
J Gerontol A Biol Sci Med Sci 2015 Apr;70(4):471-9. Epub 2014 Aug 22 doi: 10.1093/gerona/glu135. [Epub ahead of print] PMID: 25149688Free PMC Article
Pruchno RA, Wilson-Genderson M
J Gerontol B Psychol Sci Soc Sci 2015 Nov;70(6):850-9. Epub 2014 May 13 doi: 10.1093/geronb/gbu046. [Epub ahead of print] PMID: 24829305

Clinical prediction guides

Niño PK, Durik M, Danser AH, de Vries R, Musterd-Bhaggoe UM, Meima ME, Kavousi M, Ghanbari M, Hoeijmakers JH, O'Donnell CJ, Franceschini N, Janssen GM, De Mey JG, Liu Y, Shanahan CM, Franco OH, Dehghan A, Roks AJ
Clin Sci (Lond) 2015 Dec;129(12):1061-75. Epub 2015 Jun 25 doi: 10.1042/CS20140753. [Epub ahead of print] PMID: 26464516
Franzon K, Zethelius B, Cederholm T, Kilander L
J Am Geriatr Soc 2015 May;63(5):877-85. Epub 2015 Apr 27 doi: 10.1111/jgs.13352. [Epub ahead of print] PMID: 25919442
Margolick JB, Ferrucci L
Exp Gerontol 2015 Apr;64:78-80. Epub 2015 Feb 12 doi: 10.1016/j.exger.2015.02.009. [Epub ahead of print] PMID: 25683017Free PMC Article
Pruchno RA, Wilson-Genderson M
J Gerontol B Psychol Sci Soc Sci 2015 Nov;70(6):850-9. Epub 2014 May 13 doi: 10.1093/geronb/gbu046. [Epub ahead of print] PMID: 24829305
Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, Howard BV
Aging (Albany NY) 2014 Mar;6(3):176-86. PMID: 24799415Free PMC Article

Recent systematic reviews

Friedman SM, Shah K, Hall WJ
J Am Geriatr Soc 2015 Jul;63(7):1459-62. Epub 2015 Jul 14 doi: 10.1111/jgs.13512. [Epub ahead of print] PMID: 26179067
Gonzalez-Freire M, de Cabo R, Bernier M, Sollott SJ, Fabbri E, Navas P, Ferrucci L
J Gerontol A Biol Sci Med Sci 2015 Nov;70(11):1334-42. Epub 2015 May 20 doi: 10.1093/gerona/glv070. [Epub ahead of print] PMID: 25995290Free PMC Article
Dimitrakopoulou K, Vrahatis AG, Bezerianos A
BMC Genomics 2015 Mar 4;16:147. doi: 10.1186/s12864-015-1256-3. [Epub ahead of print] PMID: 25887273Free PMC Article
Glaab E, Schneider R
Neurobiol Dis 2015 Feb;74:1-13. Epub 2014 Nov 12 doi: 10.1016/j.nbd.2014.11.002. [Epub ahead of print] PMID: 25447234
Westerhof GJ, Miche M, Brothers AF, Barrett AE, Diehl M, Montepare JM, Wahl HW, Wurm S
Psychol Aging 2014 Dec;29(4):793-802. Epub 2014 Nov 3 doi: 10.1037/a0038016. [Epub ahead of print] PMID: 25365689

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