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Results: 1 to 20 of 22

1.

Malignant neoplastic disease

A general term for autonomous tissue growth exhibiting morphologic features of malignancy (e.g. severe atypia, nuclear pleomorphism, tumor cell necrosis, abnormal mitoses, tissue invasiveness) and for which the transformed cell type has not been specifically identified. [from NCI]

MedGen UID:
14297
Concept ID:
C0006826
Neoplastic Process
2.

Cyclophosphamide

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. [from MeSH]

MedGen UID:
4107
Concept ID:
C0010583
Pharmacologic Substance
3.

Detected

MedGen UID:
617726
Concept ID:
C0442726
Finding
4.

Staining (finding)

MedGen UID:
352872
Concept ID:
C1704680
Finding
5.

Cytophosphan

MedGen UID:
501178
Concept ID:
C3495431
Pharmacologic Substance
6.

Immunomodulators

agents of both drug and biological origin often used in immunotherapy to stimulate, potentiate, or depress the immune response; also used to inhibit or enhance specific subclasses of immunocytes. [from CRISP]

MedGen UID:
282900
Concept ID:
C1527392
Pharmacologic Substance
7.

MedGen UID:
196095
Concept ID:
C0701106
8.

MedGen UID:
195870
Concept ID:
C0699322
9.

MedGen UID:
195869
Concept ID:
C0699320
10.

MedGen UID:
148718
Concept ID:
C0701107
11.

MedGen UID:
148481
Concept ID:
C0699323
12.

MedGen UID:
148480
Concept ID:
C0699321
13.

A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent. [from NCI]

MedGen UID:
148479
Concept ID:
C0699319
14.

MedGen UID:
115903
Concept ID:
C0231337
15.

Myeloablative Agonists

Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION. [from MeSH]

MedGen UID:
101198
Concept ID:
C0524867
Pharmacologic Substance
16.

Nitrogen Mustard Compounds

A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens. [from MeSH]

MedGen UID:
18053
Concept ID:
C0028165
Pharmacologic Substance
17.

Phosphoramide Mustards

A group of nitrogen mustard compounds which are substituted with a phosphoramide group or its derivatives. They are usually cytotoxic and used as antineoplastic agents. [from MeSH]

MedGen UID:
10737
Concept ID:
C0031692
Pharmacologic Substance
18.

Mustard Compounds

Strong alkylating and immunosuppressive agents whose biological activity is based on the presence of bis(2-chloroethyl)- groups. Although otherwise structurally diverse, the compounds have in common the capacity to contribute alkyl groups to DNA. They are generally highly toxic but include among their number many widely used and effective antineoplastic agents. [from MeSH]

MedGen UID:
7760
Concept ID:
C0026873
Pharmacologic Substance
19.

Immunosuppressive Agents

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. [from MeSH]

MedGen UID:
7041
Concept ID:
C0021081
Pharmacologic Substance
20.

Antineoplastic Agents

NOTE: Includes hormones (AN500) which are exclusively used as antineoplastics (e.g.,tamoxifen). Excludes other hormones (HS000). [from NDF-RT]

MedGen UID:
1984
Concept ID:
C0003392
Pharmacologic Substance

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