Display Settings:

Format
Items per page

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 12

1.

Androgens

A class of sex hormones associated with the development and maintenance of the secondary male sex characteristics, sperm induction, and sexual differentiation. In addition to increasing virility and libido, they also increase nitrogen and water retention and stimulate skeletal growth. (MeSH) [from NCI]

MedGen UID:
8060
Concept ID:
C0002844
Pharmacologic Substance
2.

MedGen UID:
108591
Concept ID:
C0596843
3.

Testosterone

A synthetic form of the endogenous androgenic steroid testosterone. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative. This agent and its derivatives promote the maintenance of male sex characteristics. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C862" NCI Thesaurus) [from PDQ]

MedGen UID:
21105
Concept ID:
C0039601
Pharmacologic Substance
4.

Stanolone

The most potent androgen, required for sex development. Dihydrotestosterone is synthesized from testosterone in the prostate gland, testes, hair follicles and adrenal glands by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone, which binds to and activates specific nuclear androgen receptors. After translocation into the nucleus, the activated hormone-receptor complex binds to the androgen response elements on the DNA and activates gene expressions that are required for sex development. Dihydrotestosterone is responsible for the formation of male primary sex characteristics and most male secondary sex characteristics during puberty, such as muscular growth, facial and body hair growth, and deepening of the voice. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=511037&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=511037&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29619" NCI Thesaurus) [from PDQ]

MedGen UID:
20936
Concept ID:
C0038148
Pharmacologic Substance
5.

Up-Regulation (Physiology)

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

MedGen UID:
12003
Concept ID:
C0041904
Molecular Function
6.

Nuclear Translocation

Nuclear Translocation is a subcellular process in which activated cytoplasmic proteins are transported into the cell nucleus as part of a signal transduction pathway to modify cell function (typically gene expression) in response to a signaling event or condition. [from NCI]

MedGen UID:
273609
Concept ID:
C1518440
Molecular Function
7.

Signal Transduction Pathways

An elaboration of the known or inferred interactions involved in a signal transduction pathway. [from NCI]

MedGen UID:
39530
Concept ID:
C0086982
Molecular Function
8.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
9.

MedGen UID:
109458
Concept ID:
C0600513
10.

Hormones, Hormone Substitutes, and Hormone Antagonists

A collective grouping for both naturally occurring and synthetic hormones, substitutes, and antagonists. [from MeSH]

MedGen UID:
6887
Concept ID:
C0019934
Pharmacologic Substance
11.

Androgen Receptor Regulation Pathway

Any process that modulates the frequency, rate or extent of androgen receptor activity. [GOC:obol] [from GO]

MedGen UID:
456687
Concept ID:
C2984460
Molecular Function
12.

Decreased testosterone in males

MedGen UID:
395413
Concept ID:
C1860121
Finding

Display Settings:

Format
Items per page

Send to:

Choose Destination

Supplemental Content

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...