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Items: 2

1.

Aging

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]

MedGen UID:
1376
Concept ID:
C0001811
Organism Function
2.

Decreased number of CD8+ T cells

A decreased count of circulating CD8-positive, alpha-beta regulatory T cells. [from HPO]

MedGen UID:
374188
Concept ID:
C1839305
Finding

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