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Recombinant Interleukin-13

MedGen UID:
282742
Concept ID:
C1522557
Pharmacologic Substance
Synonyms: IL-13; Interleukin 13
 

Definition

The recombinant analogue of an endogenous cytokine interleukin 13 with potential antineoplastic activity. Produced by lymphocytes and exhibiting a variety of functions, interleukin-13 (therapeutic) inhibits DNA synthesis and regulates inflammatory and immune responses. In animal models, this agent has been shown to kill tumor cells both directly and indirectly by activating the host immune system at the tumor site. (NCI04) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGRecombinant Interleukin-13

Recent clinical studies

Etiology

Jain M, Zhang L, He M, Patterson EE, Nilubol N, Fojo AT, Joshi B, Puri R, Kebebew E
Cancer 2012 Nov 15;118(22):5698-708. Epub 2012 May 8 doi: 10.1002/cncr.27629. [Epub ahead of print] PMID: 22570059Free PMC Article
Thaikoottathil JV, Martin RJ, Di PY, Minor M, Case S, Zhang B, Zhang G, Huang H, Chu HW
Am J Respir Cell Mol Biol 2012 Aug;47(2):253-60. Epub 2012 Apr 12 doi: 10.1165/rcmb.2012-0064OC. [Epub ahead of print] PMID: 22499853Free PMC Article
He S, Zhang Z, Zhang H, Wei J, Yang L, Yang H, Sun W, Zeng X, Yang P
Scand J Immunol 2011 Sep;74(3):288-95. doi: 10.1111/j.1365-3083.2011.02571.x. PMID: 21535080
Parney IF, Kunwar S, McDermott M, Berger M, Prados M, Cha S, Croteau D, Puri RK, Chang SM
J Neurosurg 2005 Feb;102(2):267-75. doi: 10.3171/jns.2005.102.2.0267. PMID: 15739554
Roberge FG, de Smet MD, Benichou J, Kriete MF, Raber J, Hakimi J
Br J Ophthalmol 1998 Oct;82(10):1195-8. PMID: 9924310Free PMC Article

Diagnosis

Chittiboina P, Heiss JD, Warren KE, Lonser RR
J Neurosurg Pediatr 2014 Mar;13(3):276-82. Epub 2014 Jan 10 doi: 10.3171/2013.11.PEDS136. [Epub ahead of print] PMID: 24410126Free PMC Article
Nguyen V, Conyers JM, Zhu D, Gibo DM, Hantgan RR, Larson SM, Debinski W, Mintz A
Neuro Oncol 2012 Oct;14(10):1239-53. Epub 2012 Sep 5 doi: 10.1093/neuonc/nos211. [Epub ahead of print] PMID: 22952195Free PMC Article
Morzadec C, Bouezzedine F, Macoch M, Fardel O, Vernhet L
Toxicology 2012 Oct 9;300(1-2):46-56. Epub 2012 Jun 6 doi: 10.1016/j.tox.2012.05.025. [Epub ahead of print] PMID: 22683347
Jain M, Zhang L, He M, Patterson EE, Nilubol N, Fojo AT, Joshi B, Puri R, Kebebew E
Cancer 2012 Nov 15;118(22):5698-708. Epub 2012 May 8 doi: 10.1002/cncr.27629. [Epub ahead of print] PMID: 22570059Free PMC Article
Chu Y, Hua L, Liu Q, Bao Y
Int J Immunogenet 2012 Aug;39(4):308-13. Epub 2012 Feb 10 doi: 10.1111/j.1744-313X.2012.01091.x. [Epub ahead of print] PMID: 22325047

Therapy

Chittiboina P, Heiss JD, Warren KE, Lonser RR
J Neurosurg Pediatr 2014 Mar;13(3):276-82. Epub 2014 Jan 10 doi: 10.3171/2013.11.PEDS136. [Epub ahead of print] PMID: 24410126Free PMC Article
Hall B, Nakashima H, Sun ZJ, Sato Y, Bian Y, Husain SR, Puri RK, Kulkarni AB
J Transl Med 2013 Feb 19;11:45. doi: 10.1186/1479-5876-11-45. [Epub ahead of print] PMID: 23421960Free PMC Article
Yin H, Li XY, Liu T, Yuan BH, Zhang BB, Hu SL, Gu HB, Jin XB, Zhu JY
Clin Exp Immunol 2012 Oct;170(1):1-9. doi: 10.1111/j.1365-2249.2012.04629.x. PMID: 22943195Free PMC Article
Jain M, Zhang L, He M, Patterson EE, Nilubol N, Fojo AT, Joshi B, Puri R, Kebebew E
Cancer 2012 Nov 15;118(22):5698-708. Epub 2012 May 8 doi: 10.1002/cncr.27629. [Epub ahead of print] PMID: 22570059Free PMC Article
Hardy CL, Lemasurier JS, Olsson F, Dang T, Yao J, Yang M, Plebanski M, Phillips DJ, Mollard R, Rolland JM, O'Hehir RE
Am J Respir Cell Mol Biol 2010 Jun;42(6):667-75. Epub 2009 Jul 27 doi: 10.1165/rcmb.2008-0429OC. [Epub ahead of print] PMID: 19635933

Prognosis

Yu S, Zhang R, Zhu C, Cheng J, Wang H, Wu J
Int J Mol Sci 2013 Aug 19;14(8):16958-69. doi: 10.3390/ijms140816958. PMID: 23965966Free PMC Article
Hegde M, Corder A, Chow KK, Mukherjee M, Ashoori A, Kew Y, Zhang YJ, Baskin DS, Merchant FA, Brawley VS, Byrd TT, Krebs S, Wu MF, Liu H, Heslop HE, Gottschalk S, Yvon E, Ahmed N
Mol Ther 2013 Nov;21(11):2087-101. Epub 2013 Aug 13 doi: 10.1038/mt.2013.185. [Epub ahead of print] PMID: 23939024Free PMC Article
Crawford JR, Pilling D, Gomer RH
J Leukoc Biol 2012 Oct;92(4):699-711. Epub 2012 Apr 9 doi: 10.1189/jlb.0112033. [Epub ahead of print] PMID: 22493081Free PMC Article
Yu W, Su Z, Wu Z, Mao X, Zheng W, Zeng Y
Cancer Immunol Immunother 2009 Mar;58(3):409-13. Epub 2008 Aug 2 doi: 10.1007/s00262-008-0566-6. [Epub ahead of print] PMID: 18677476
Yang S, Boroughs KL, McDermott MJ
J Interferon Cytokine Res 2000 Sep;20(9):779-85. doi: 10.1089/10799900050151049. PMID: 11032397

Clinical prediction guides

Krebs S, Chow KK, Yi Z, Rodriguez-Cruz T, Hegde M, Gerken C, Ahmed N, Gottschalk S
Cytotherapy 2014 Aug;16(8):1121-31. Epub 2014 May 16 doi: 10.1016/j.jcyt.2014.02.012. [Epub ahead of print] PMID: 24841514Free PMC Article
Yu S, Zhang R, Zhu C, Cheng J, Wang H, Wu J
Int J Mol Sci 2013 Aug 19;14(8):16958-69. doi: 10.3390/ijms140816958. PMID: 23965966Free PMC Article
Provost V, Langlois A, Chouinard F, Rola-Pleszczynski M, Chakir J, Flamand N, Laviolette M
PLoS One 2012;7(8):e43544. Epub 2012 Aug 31 doi: 10.1371/journal.pone.0043544. PMID: 22952702Free PMC Article
Ito Y, Mason RJ
Respir Res 2010 Nov 10;11:157. doi: 10.1186/1465-9921-11-157. [Epub ahead of print] PMID: 21067601Free PMC Article
Hardy CL, Lemasurier JS, Olsson F, Dang T, Yao J, Yang M, Plebanski M, Phillips DJ, Mollard R, Rolland JM, O'Hehir RE
Am J Respir Cell Mol Biol 2010 Jun;42(6):667-75. Epub 2009 Jul 27 doi: 10.1165/rcmb.2008-0429OC. [Epub ahead of print] PMID: 19635933

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