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Multiple endocrine neoplasia

MedGen UID:
45036
Concept ID:
C0027662
Neoplastic Process
Synonyms: Adenomatoses, Familial Endocrine; Adenomatoses, Multiple Endocrine; Adenomatosis, Familial Endocrine; Adenomatosis, Multiple Endocrine; Adenopathies, Multiple Endocrine; Adenopathy, Multiple Endocrine; Endocrine Adenomatoses, Familial; Endocrine Adenomatoses, Multiple; Endocrine Adenomatosis, Familial; Endocrine Adenomatosis, Multiple; Endocrine Adenopathies, Multiple; Endocrine Adenopathy, Multiple; Endocrine Neoplasia, Multiple; Endocrine Neoplasms, Multiple; Familial Endocrine Adenomatoses; Familial Endocrine Adenomatosis; Multiple Endocrine Adenomatoses; Multiple Endocrine Adenomatosis; Multiple Endocrine Adenopathies; Multiple Endocrine Adenopathy; Multiple Endocrine Neoplasia; Multiple Endocrine Neoplasia Syndromes; Multiple Endocrine Neoplasms; Neoplasia, Multiple Endocrine; Neoplasms, Multiple Endocrine
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: HPO, OMIM, Orphanet
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
Autosomal dominant inheritance (HPO, OMIM, Orphanet)
not inherited (Orphanet)
SNOMED CT: Multiple endocrine adenomas (60549007); Endocrine adenomatosis (60549007); MEN - Multiple endocrine neoplasia (46724008); Multiple endocrine tumasia (46724008); MEA - Multiple endocrine adenomatosis (46724008); Familial polyendocrine adenomatosis (46724008); Multiple endocrine neoplasia (46724008)
 
Orphanet: ORPHA276161

Definition

An inherited condition that may result in the development of cancers of the endocrine system. There are several types of multiple endocrine neoplasia syndrome, and patients with each type may develop different types of cancer. The altered genes that cause each type can be detected with a blood test. [from NCI]

Recent clinical studies

Etiology

Tsang VH, Tacon LJ, Learoyd DL, Robinson BG
Recent Results Cancer Res 2015;204:157-78. doi: 10.1007/978-3-319-22542-5_7. PMID: 26494388
Norton JA, Krampitz G, Jensen RT
Surg Oncol Clin N Am 2015 Oct;24(4):795-832. Epub 2015 Jul 27 doi: 10.1016/j.soc.2015.06.008. [Epub ahead of print] PMID: 26363542Free PMC Article
Singh Ospina N, Thompson GB, C Nichols F 3rd, Cassivi SD, Young WF Jr
Horm Cancer 2015 Dec;6(5-6):247-53. Epub 2015 Jun 13 doi: 10.1007/s12672-015-0228-z. [Epub ahead of print] PMID: 26070346
Gurung B, Hua X, Runske M, Bennett B, LiVolsi V, Roses R, Fraker DA, Metz DC
Cancer Biol Ther 2015;16(2):219-24. doi: 10.4161/15384047.2014.987574. PMID: 25482929Free PMC Article
Thakker RV
Mol Cell Endocrinol 2014 Apr 5;386(1-2):2-15. Epub 2013 Aug 8 doi: 10.1016/j.mce.2013.08.002. [Epub ahead of print] PMID: 23933118Free PMC Article

Diagnosis

Norton JA, Krampitz G, Jensen RT
Surg Oncol Clin N Am 2015 Oct;24(4):795-832. Epub 2015 Jul 27 doi: 10.1016/j.soc.2015.06.008. [Epub ahead of print] PMID: 26363542Free PMC Article
Giri D, McKay V, Weber A, Blair JC
Arch Dis Child 2015 Oct;100(10):994-9. Epub 2015 Apr 8 doi: 10.1136/archdischild-2014-307028. [Epub ahead of print] PMID: 25854874
Sharma P, Mukherjee A, Karunanithi S, Naswa N, Kumar R, Ammini AC, Bal C
Clin Nucl Med 2015 Jul;40(7):e351-6. doi: 10.1097/RLU.0000000000000775. PMID: 25783509
Gurung B, Hua X, Runske M, Bennett B, LiVolsi V, Roses R, Fraker DA, Metz DC
Cancer Biol Ther 2015;16(2):219-24. doi: 10.4161/15384047.2014.987574. PMID: 25482929Free PMC Article
Thakker RV
Mol Cell Endocrinol 2014 Apr 5;386(1-2):2-15. Epub 2013 Aug 8 doi: 10.1016/j.mce.2013.08.002. [Epub ahead of print] PMID: 23933118Free PMC Article

Therapy

Narayanan VK, Ronghe M, MacGregor FB, Bradshaw N, Davidson R, Welbury R, Reed N, Shaikh MG
J Pediatr Hematol Oncol 2016 Mar;38(2):155-7. doi: 10.1097/MPH.0000000000000432. PMID: 26479990
Tsang VH, Tacon LJ, Learoyd DL, Robinson BG
Recent Results Cancer Res 2015;204:157-78. doi: 10.1007/978-3-319-22542-5_7. PMID: 26494388
Sadowski SM, Millo C, Cottle-Delisle C, Merkel R, Yang LA, Herscovitch P, Pacak K, Simonds WF, Marx SJ, Kebebew E
J Am Coll Surg 2015 Aug;221(2):509-17. Epub 2015 Apr 20 doi: 10.1016/j.jamcollsurg.2015.04.005. [Epub ahead of print] PMID: 26206648Free PMC Article
Singh Ospina N, Thompson GB, Lee RA, Reading CC, Young WF Jr
J Clin Endocrinol Metab 2015 Jan;100(1):E87-90. doi: 10.1210/jc.2014-3255. PMID: 25337928
Tamiya H, Miyakawa M, Takeshita A, Miura D, Takeuchi Y
J Bone Miner Metab 2015 Sep;33(5):523-9. Epub 2014 Sep 17 doi: 10.1007/s00774-014-0614-6. [Epub ahead of print] PMID: 25227285

Prognosis

Tsang VH, Tacon LJ, Learoyd DL, Robinson BG
Recent Results Cancer Res 2015;204:157-78. doi: 10.1007/978-3-319-22542-5_7. PMID: 26494388
Singh Ospina N, Thompson GB, C Nichols F 3rd, Cassivi SD, Young WF Jr
Horm Cancer 2015 Dec;6(5-6):247-53. Epub 2015 Jun 13 doi: 10.1007/s12672-015-0228-z. [Epub ahead of print] PMID: 26070346
Sharma P, Mukherjee A, Karunanithi S, Naswa N, Kumar R, Ammini AC, Bal C
Clin Nucl Med 2015 Jul;40(7):e351-6. doi: 10.1097/RLU.0000000000000775. PMID: 25783509
Gurung B, Hua X, Runske M, Bennett B, LiVolsi V, Roses R, Fraker DA, Metz DC
Cancer Biol Ther 2015;16(2):219-24. doi: 10.4161/15384047.2014.987574. PMID: 25482929Free PMC Article
Mejía-Castrejón J, Landa-Ramírez E
BMJ Case Rep 2014 Jun 4;2014 doi: 10.1136/bcr-2013-202242. PMID: 24898996Free PMC Article

Clinical prediction guides

Tsang VH, Tacon LJ, Learoyd DL, Robinson BG
Recent Results Cancer Res 2015;204:157-78. doi: 10.1007/978-3-319-22542-5_7. PMID: 26494388
Sharma P, Mukherjee A, Karunanithi S, Naswa N, Kumar R, Ammini AC, Bal C
Clin Nucl Med 2015 Jul;40(7):e351-6. doi: 10.1097/RLU.0000000000000775. PMID: 25783509
Gurung B, Hua X, Runske M, Bennett B, LiVolsi V, Roses R, Fraker DA, Metz DC
Cancer Biol Ther 2015;16(2):219-24. doi: 10.4161/15384047.2014.987574. PMID: 25482929Free PMC Article
Tamiya H, Miyakawa M, Takeshita A, Miura D, Takeuchi Y
J Bone Miner Metab 2015 Sep;33(5):523-9. Epub 2014 Sep 17 doi: 10.1007/s00774-014-0614-6. [Epub ahead of print] PMID: 25227285
Castinetti F, Qi XP, Walz MK, Maia AL, Sansó G, Peczkowska M, Hasse-Lazar K, Links TP, Dvorakova S, Toledo RA, Mian C, Bugalho MJ, Wohllk N, Kollyukh O, Canu L, Loli P, Bergmann SR, Biarnes Costa J, Makay O, Patocs A, Pfeifer M, Shah NS, Cuny T, Brauckhoff M, Bausch B, von Dobschuetz E, Letizia C, Barczynski M, Alevizaki MK, Czetwertynska M, Ugurlu MU, Valk G, Plukker JT, Sartorato P, Siqueira DR, Barontini M, Szperl M, Jarzab B, Verbeek HH, Zelinka T, Vlcek P, Toledo SP, Coutinho FL, Mannelli M, Recasens M, Demarquet L, Petramala L, Yaremchuk S, Zabolotnyi D, Schiavi F, Opocher G, Racz K, Januszewicz A, Weryha G, Henry JF, Brue T, Conte-Devolx B, Eng C, Neumann HP
Lancet Oncol 2014 May;15(6):648-55. Epub 2014 Apr 15 doi: 10.1016/S1470-2045(14)70154-8. [Epub ahead of print] PMID: 24745698

Recent systematic reviews

Coyle D, Friedmacher F, Puri P
Pediatr Surg Int 2014 Aug;30(8):751-6. Epub 2014 Jun 28 doi: 10.1007/s00383-014-3538-2. [Epub ahead of print] PMID: 24972642
Krampitz GW, Norton JA
Cancer 2014 Jul 1;120(13):1920-31. Epub 2014 Apr 3 doi: 10.1002/cncr.28661. [Epub ahead of print] PMID: 24699901
Wells SA Jr, Pacini F, Robinson BG, Santoro M
J Clin Endocrinol Metab 2013 Aug;98(8):3149-64. Epub 2013 Jun 6 doi: 10.1210/jc.2013-1204. [Epub ahead of print] PMID: 23744408
Lee M, Pellegata NS
Front Horm Res 2013;41:63-78. Epub 2013 Mar 19 doi: 10.1159/000345670. [Epub ahead of print] PMID: 23652671
Lourenço DM Jr, Coutinho FL, Toledo RA, Gonçalves TD, Montenegro FL, Toledo SP
Clinics (Sao Paulo) 2012;67 Suppl 1:99-108. PMID: 22584713Free PMC Article

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