Display Settings:

Format
Items per page

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 1 to 20 of 31

1.

Azathioprine

an immunosuppressive drug [from CHV]

MedGen UID:
13991
Concept ID:
C0004482
Pharmacologic Substance
2.

Inflammation of the large intestine

MedGen UID:
505065
Concept ID:
CN001842
Finding
3.

Inflammatory bowel disease

A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type. [from NCI]

MedGen UID:
43877
Concept ID:
C0021390
Disease or Syndrome
4.

Thioguanine

thioguanine is USP. [from CRISP]

MedGen UID:
21146
Concept ID:
C0039902
Pharmacologic Substance
5.

Inosine

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed) [from MeSH]

MedGen UID:
9477
Concept ID:
C0021528
Pharmacologic Substance
6.

Thioguanine

MedGen UID:
450038
Concept ID:
CN077563
Pharmacologic Substance
7.

Withdrawal (dysfunction)

A social or emotional detachment, pathological retreat from objective reality, interpersonal contact and social involvement, as in some forms of schizophrenia, depression, or schizoid, avoidant, or schizotypal personality disorders. [from NCI]

MedGen UID:
442895
Concept ID:
C2825032
Mental or Behavioral Dysfunction
8.

PROGRESSIVE ENCEPHALOMYELITIS WITH RIGIDITY

MedGen UID:
349287
Concept ID:
C1861457
Disease or Syndrome
9.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
10.

Influenza-like symptoms

A group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite, and dry cough. Flu-like symptoms are observed in patients infected with various viruses, including hepatitis virus and HIV (initial phase), and with malignancies. [from NCI]

MedGen UID:
140262
Concept ID:
C0392171
Sign or Symptom
11.

Thiopurine methyltransferase deficiency

TPMT deficiency is an autosomal recessive trait associated with severe hematopoietic toxicity when patients are treated with standard doses of the antineoplastic agents 6-mercaptopurine (6MP) or 6-thioguanine (6TG), or the immunosuppressant azathioprine (AZA) (Lennard et al., 1989). The thiopurines are pro-drugs that require extensive metabolism in order to exert their cytotoxic action. Azathioprine is non-enzymatically reduced to 6MP. 6MP and 6TG are activated by HPRT (308000) and subsequent steps to form cytotoxic thioguanine nucleotides (TGNs) which are incorporated into DNA and/or RNA, causing DNA-protein cross-links, single-strand breaks, interstrand cross-links, and sister chromatid exchange. TPMT functions mainly to inactivate these drugs; thus, a deficiency of TPMT results in increased conversion to toxic TGNs, which can result in myelosuppression (Coulthard and Hogarth, 2005). However, 6MP is unique in that it can also be converted via TPMT into a methyl-thioinosine 5-prime monophosphate (MeTIMP), a metabolite that inhibits de novo purine synthesis and likely contributes to the cytotoxic effect of 6MP (Vogt et al., 1993; Krynetski et al., 1995; Coulthard and Hogarth, 2005). [from OMIM]

MedGen UID:
83352
Concept ID:
C0342801
Disease or Syndrome
12.

Immunomodulators

agents of both drug and biological origin often used in immunotherapy to stimulate, potentiate, or depress the immune response; also used to inhibit or enhance specific subclasses of immunocytes. [from CRISP]

MedGen UID:
282900
Concept ID:
C1527392
Pharmacologic Substance
13.

Purinethol

A drug used to treat acute lymphatic leukemia. It belongs to the family of drugs called antimetabolites. [from NCI]

MedGen UID:
196307
Concept ID:
C0722911
Pharmacologic Substance
14.

Purimethol

MedGen UID:
182436
Concept ID:
C0917847
Pharmacologic Substance
15.

Leupurin

MedGen UID:
149060
Concept ID:
C0729100
Pharmacologic Substance
16.

Imurel

MedGen UID:
146987
Concept ID:
C0699280
Pharmacologic Substance
17.

Imuran

MedGen UID:
146986
Concept ID:
C0699279
Pharmacologic Substance
18.

Disorder of gastrointestinal tract

A non-neoplastic or neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. [from NCI]

MedGen UID:
8970
Concept ID:
C0017178
Disease or Syndrome
19.

Gastroenteritis

Inflammation of the mucous membrane of the stomach and intestines [from CHV]

MedGen UID:
8967
Concept ID:
C0017160
Disease or Syndrome
20.

Elderly person

A person 65 through 79 years of age. For a person older than 79 years, AGED, 80 AND OVER is available. [from MeSH]

MedGen UID:
7927
Concept ID:
C0001792
Finding

Display Settings:

Format
Items per page

Send to:

Choose Destination

Supplemental Content

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...