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Items: 2

1.

Middle age onset

A type of adult onset with onset of symptoms at the age of 40 to 60 years. [from HPO]

MedGen UID:
409810
Concept ID:
C1969363
Finding
2.

Aging

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]

MedGen UID:
1376
Concept ID:
C0001811
Organism Function

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