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Dopachrome isomerase

MedGen UID:
48007
Concept ID:
C0114832
Pharmacologic Substance
Synonyms: 3,4-dihydroxyphenylalaninechrome tautomerase; dopachrome conversion factor; dopachrome isomerase; dopachrome oxidoreductase; dopachrome tautomerase; TRP-2 protein, tyrosinase-related; tyrosinase-related protein-2
SNOMED CT: Dopachrome isomerase (130890005); Dopachrome D-isomerase (130890005); Dopachrome delta-isomerase (130890005)
 

Definition

L-dopachrome tautomerase (519 aa, ~59 kDa) is encoded by the human DCT gene. This protein is involved in the biosynthesis of melanin. [from NCI]

Recent clinical studies

Etiology

Kemp EH, Sandhu HK, Weetman AP, McDonagh AJ
Br J Dermatol 2011 Dec;165(6):1236-43. Epub 2011 Nov 17 doi: 10.1111/j.1365-2133.2011.10597.x. [Epub ahead of print] PMID: 21895622
Bouakaze C, Keyser C, Crubézy E, Montagnon D, Ludes B
Int J Legal Med 2009 Jul;123(4):315-25. Epub 2009 May 5 doi: 10.1007/s00414-009-0348-5. [Epub ahead of print] PMID: 19415315
Liu H, Xiong X, Li Z, Xin J, Tao X, Hu Y
J Huazhong Univ Sci Technolog Med Sci 2008 Apr;28(2):132-5. Epub 2008 May 15 doi: 10.1007/s11596-008-0204-8. [Epub ahead of print] PMID: 18480980
Alonso S, Izagirre N, Smith-Zubiaga I, Gardeazabal J, Díaz-Ramón JL, Díaz-Pérez JL, Zelenika D, Boyano MD, Smit N, de la Rúa C
BMC Evol Biol 2008 Feb 29;8:74. doi: 10.1186/1471-2148-8-74. [Epub ahead of print] PMID: 18312627Free PMC Article
Roberts DW, Newton RA, Leonard JH, Sturm RA
J Cell Physiol 2008 May;215(2):344-55. doi: 10.1002/jcp.21318. PMID: 17960564

Diagnosis

Iwata T, Taniguchi H, Kuwajima M, Taniguchi T, Okuda Y, Sukeno A, Ishimoto K, Mizusawa N, Yoshimoto K
PLoS One 2012;7(3):e33402. Epub 2012 Mar 12 doi: 10.1371/journal.pone.0033402. PMID: 22428043Free PMC Article
Lai IL, Lin TP, Yao YL, Lin CY, Hsieh MJ, Yang WM
J Biol Chem 2010 Mar 5;285(10):7187-96. Epub 2009 Dec 22 doi: 10.1074/jbc.M109.061861. [Epub ahead of print] PMID: 20032463Free PMC Article
Klarquist J, Barfuss A, Kandala S, Reust MJ, Braun RK, Hu J, Dilling DF, McKee MD, Boissy RE, Love RB, Nishimura MI, Le Poole IC
Am J Pathol 2009 Dec;175(6):2463-72. Epub 2009 Nov 5 doi: 10.2353/ajpath.2009.090525. [Epub ahead of print] PMID: 19893037Free PMC Article
Michard Q, Commo S, Rocchetti J, El Houari F, Alleaume AM, Wakamatsu K, Ito S, Bernard BA
Free Radic Biol Med 2008 Oct 1;45(7):1002-10. Epub 2008 Jul 10 doi: 10.1016/j.freeradbiomed.2008.06.030. [Epub ahead of print] PMID: 18674612
Nellaiappan K, Nicklas G, Sugumaran M
Anal Biochem 1994 Jul;220(1):122-8. doi: 10.1006/abio.1994.1307. PMID: 7526730

Therapy

Lim JH, Park SH, Kim MR, Yoo BS, Yang JC, Cheong IW, Kim JH, Cho JH
Biol Pharm Bull 2013;36(3):346-51. Epub 2012 Dec 17 [Epub ahead of print] PMID: 23258078
Steitz J, Tüting T
Methods Mol Biol 2013;940:317-37. doi: 10.1007/978-1-62703-110-3_24. PMID: 23104352
Ishii-Osai Y, Yamashita T, Tamura Y, Sato N, Ito A, Honda H, Wakamatsu K, Ito S, Nakayama E, Okura M, Jimbow K
J Dermatol Sci 2012 Jul;67(1):51-60. Epub 2012 May 2 doi: 10.1016/j.jdermsci.2012.04.009. [Epub ahead of print] PMID: 22622238
Kim JY, Shin JY, Kim MR, Hann SK, Oh SH
Exp Dermatol 2012 Jun;21(6):420-5. Epub 2012 Apr 16 doi: 10.1111/j.1600-0625.2012.01483.x. [Epub ahead of print] PMID: 22506937
Avogadri F, Merghoub T, Maughan MF, Hirschhorn-Cymerman D, Morris J, Ritter E, Olmsted R, Houghton AN, Wolchok JD
PLoS One 2010 Sep 10;5(9) doi: 10.1371/journal.pone.0012670. PMID: 20844763Free PMC Article

Prognosis

Wang P, Li Y, Hong W, Zhen J, Ren J, Li Z, Xu A
Mol Biosyst 2012 Nov;8(11):2924-31. doi: 10.1039/c2mb25228g. PMID: 22898827
Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO
Nature 2010 Jun 3;465(7298):577-83. doi: 10.1038/nature09141. PMID: 20520707Free PMC Article
Grinshtein N, Bridle B, Wan Y, Bramson JL
Cancer Res 2009 May 1;69(9):3979-85. Epub 2009 Apr 21 doi: 10.1158/0008-5472.CAN-08-3385. [Epub ahead of print] PMID: 19383917
Tang Y, Lin Z, Ni B, Wei J, Han J, Wang H, Wu Y
Cancer Immunol Immunother 2007 Mar;56(3):319-29. Epub 2006 Aug 12 doi: 10.1007/s00262-006-0195-x. [Epub ahead of print] PMID: 16906394
Paschen A, Jing W, Drexler I, Klemm M, Song M, Müller-Berghaus J, Nguyen XD, Osen W, Stevanovic S, Sutter G, Schadendorf D
Int J Cancer 2005 Oct 10;116(6):944-8. doi: 10.1002/ijc.21132. PMID: 15856458

Clinical prediction guides

Steitz J, Tüting T
Methods Mol Biol 2013;940:317-37. doi: 10.1007/978-1-62703-110-3_24. PMID: 23104352
Wang P, Li Y, Hong W, Zhen J, Ren J, Li Z, Xu A
Mol Biosyst 2012 Nov;8(11):2924-31. doi: 10.1039/c2mb25228g. PMID: 22898827
Zhao Z, Jin C, Ding K, Ge X, Dai L
Exp Dermatol 2012 Jul;21(7):504-8. Epub 2012 Apr 29 doi: 10.1111/j.1600-0625.2012.01488.x. [Epub ahead of print] PMID: 22540983
Bultema JJ, Ambrosio AL, Burek CL, Di Pietro SM
J Biol Chem 2012 Jun 1;287(23):19550-63. Epub 2012 Apr 16 doi: 10.1074/jbc.M112.351908. [Epub ahead of print] PMID: 22511774Free PMC Article
Iwata T, Taniguchi H, Kuwajima M, Taniguchi T, Okuda Y, Sukeno A, Ishimoto K, Mizusawa N, Yoshimoto K
PLoS One 2012;7(3):e33402. Epub 2012 Mar 12 doi: 10.1371/journal.pone.0033402. PMID: 22428043Free PMC Article

Recent systematic reviews

Strunnikova NV, Maminishkis A, Barb JJ, Wang F, Zhi C, Sergeev Y, Chen W, Edwards AO, Stambolian D, Abecasis G, Swaroop A, Munson PJ, Miller SS
Hum Mol Genet 2010 Jun 15;19(12):2468-86. Epub 2010 Apr 1 doi: 10.1093/hmg/ddq129. [Epub ahead of print] PMID: 20360305Free PMC Article

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