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Epoetin Alfa

MedGen UID:
138126
Concept ID:
C0357126
Pharmacologic Substance
Synonyms: 1-165-Erythropoietin (human clone lambdaHEPOFL13 protein moiety), glycoform alpha; epoetin alfa; recombinant 1-165 erythropoietin, glycoform alpha
SNOMED CT: Epoetin alfa product (108964008); Epoetin alfa (386947003); Epoetin alfa (108964008)
 

Definition

This recombinant erythropoietin, a 165-amino acid glycoprotein (about 62% protein and 38% carbohydrate), regulates red blood cell production. Epoetin alfa is produced by Chinese hamster ovary cells into which the human erythropoietin gene has been inserted. (USP Dictionary of USAN and International Drug Names, 1996). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGEpoetin Alfa

Recent clinical studies

Etiology

Moebus V, Jackisch C, Schneeweiss A, Huober J, Lueck HJ, du Bois A, Thomssen C, Kurbacher C, Kuhn W, Nitz U, Runnebaum IB, Hinke A, Kreienberg R, Untch M; AGO Breast Study Group
J Natl Cancer Inst 2013 Jul 17;105(14):1018-26. Epub 2013 Jul 16 doi: 10.1093/jnci/djt145. [Epub ahead of print] PMID: 23860204Free PMC Article
Fokkema ML, Kleijn L, van der Meer P, Belonje AM, Achterhof SK, Hillege HL, van 't Hof A, Jukema JW, Peels HO, Henriques JP, ten Berg JM, Vos J, van Gilst WH, van Veldhuisen DJ, Voors AA
Cardiovasc Drugs Ther 2013 Oct;27(5):433-9. doi: 10.1007/s10557-013-6470-0. PMID: 23784615
McCullough PA, Barnhart HX, Inrig JK, Reddan D, Sapp S, Patel UD, Singh AK, Szczech LA, Califf RM
Am J Nephrol 2013;37(6):549-58. Epub 2013 May 25 doi: 10.1159/000351175. [Epub ahead of print] PMID: 23735819
Green P, Babu BA, Teruya S, Helmke S, Prince M, Maurer MS
Congest Heart Fail 2013 Jul-Aug;19(4):172-9. Epub 2013 Mar 20 doi: 10.1111/chf.12027. [Epub ahead of print] PMID: 23517485Free PMC Article
Chui BK, Pannu N, Hazel M, Dong J, Tonelli M, Klarenbach SW
J Trauma Acute Care Surg 2012 Jul;73(1):195-201. doi: 10.1097/TA.0b013e31824ba1da. PMID: 22710785

Diagnosis

Gaweda AE, Bhat P, Maglinte GA, Chang CL, Hill J, Park GS, Ashfaq A, Gitlin M
Hemodial Int 2014 Jan;18(1):38-46. Epub 2013 Aug 22 doi: 10.1111/hdi.12078. [Epub ahead of print] PMID: 23968235
Tomeczkowski J, Stern S, Müller A, von Heymann C
PLoS One 2013;8(9):e72949. Epub 2013 Sep 9 doi: 10.1371/journal.pone.0072949. PMID: 24039829Free PMC Article
Gesualdo L, London G, Turner M, Lee C, Macdonald K, Goldsmith D, Covic A, Zaoui P, Combe C, Mann J, Dellanna F, Muenzberg M, Abraham I
Intern Emerg Med 2013 Aug;8(5):389-99. Epub 2011 May 18 doi: 10.1007/s11739-011-0622-7. [Epub ahead of print] PMID: 21590439
Chui BK, Pannu N, Hazel M, Dong J, Tonelli M, Klarenbach SW
J Trauma Acute Care Surg 2012 Jul;73(1):195-201. doi: 10.1097/TA.0b013e31824ba1da. PMID: 22710785
Stowell CP, Jones SC, Enny C, Langholff W, Leitz G
Spine (Phila Pa 1976) 2009 Nov 1;34(23):2479-85. doi: 10.1097/BRS.0b013e3181bd163f. PMID: 19927096

Therapy

Moebus V, Jackisch C, Schneeweiss A, Huober J, Lueck HJ, du Bois A, Thomssen C, Kurbacher C, Kuhn W, Nitz U, Runnebaum IB, Hinke A, Kreienberg R, Untch M; AGO Breast Study Group
J Natl Cancer Inst 2013 Jul 17;105(14):1018-26. Epub 2013 Jul 16 doi: 10.1093/jnci/djt145. [Epub ahead of print] PMID: 23860204Free PMC Article
Fokkema ML, Kleijn L, van der Meer P, Belonje AM, Achterhof SK, Hillege HL, van 't Hof A, Jukema JW, Peels HO, Henriques JP, ten Berg JM, Vos J, van Gilst WH, van Veldhuisen DJ, Voors AA
Cardiovasc Drugs Ther 2013 Oct;27(5):433-9. doi: 10.1007/s10557-013-6470-0. PMID: 23784615
McCullough PA, Barnhart HX, Inrig JK, Reddan D, Sapp S, Patel UD, Singh AK, Szczech LA, Califf RM
Am J Nephrol 2013;37(6):549-58. Epub 2013 May 25 doi: 10.1159/000351175. [Epub ahead of print] PMID: 23735819
Green P, Babu BA, Teruya S, Helmke S, Prince M, Maurer MS
Congest Heart Fail 2013 Jul-Aug;19(4):172-9. Epub 2013 Mar 20 doi: 10.1111/chf.12027. [Epub ahead of print] PMID: 23517485Free PMC Article
Chui BK, Pannu N, Hazel M, Dong J, Tonelli M, Klarenbach SW
J Trauma Acute Care Surg 2012 Jul;73(1):195-201. doi: 10.1097/TA.0b013e31824ba1da. PMID: 22710785

Prognosis

Gaweda AE, Bhat P, Maglinte GA, Chang CL, Hill J, Park GS, Ashfaq A, Gitlin M
Hemodial Int 2014 Jan;18(1):38-46. Epub 2013 Aug 22 doi: 10.1111/hdi.12078. [Epub ahead of print] PMID: 23968235
Moebus V, Jackisch C, Schneeweiss A, Huober J, Lueck HJ, du Bois A, Thomssen C, Kurbacher C, Kuhn W, Nitz U, Runnebaum IB, Hinke A, Kreienberg R, Untch M; AGO Breast Study Group
J Natl Cancer Inst 2013 Jul 17;105(14):1018-26. Epub 2013 Jul 16 doi: 10.1093/jnci/djt145. [Epub ahead of print] PMID: 23860204Free PMC Article
Green P, Babu BA, Teruya S, Helmke S, Prince M, Maurer MS
Congest Heart Fail 2013 Jul-Aug;19(4):172-9. Epub 2013 Mar 20 doi: 10.1111/chf.12027. [Epub ahead of print] PMID: 23517485Free PMC Article
Gesualdo L, London G, Turner M, Lee C, Macdonald K, Goldsmith D, Covic A, Zaoui P, Combe C, Mann J, Dellanna F, Muenzberg M, Abraham I
Intern Emerg Med 2013 Aug;8(5):389-99. Epub 2011 May 18 doi: 10.1007/s11739-011-0622-7. [Epub ahead of print] PMID: 21590439
Saccà F, Piro R, De Michele G, Acquaviva F, Antenora A, Carlomagno G, Cocozza S, Denaro A, Guacci A, Marsili A, Perrotta G, Puorro G, Cittadini A, Filla A
Mov Disord 2011 Mar;26(4):739-42. Epub 2010 Nov 10 doi: 10.1002/mds.23435. [Epub ahead of print] PMID: 21506154

Clinical prediction guides

Gaweda AE, Bhat P, Maglinte GA, Chang CL, Hill J, Park GS, Ashfaq A, Gitlin M
Hemodial Int 2014 Jan;18(1):38-46. Epub 2013 Aug 22 doi: 10.1111/hdi.12078. [Epub ahead of print] PMID: 23968235
McCullough PA, Barnhart HX, Inrig JK, Reddan D, Sapp S, Patel UD, Singh AK, Szczech LA, Califf RM
Am J Nephrol 2013;37(6):549-58. Epub 2013 May 25 doi: 10.1159/000351175. [Epub ahead of print] PMID: 23735819
Maurer MS, Teruya S, Chakraborty B, Helmke S, Mancini D
Circ Heart Fail 2013 Mar;6(2):254-63. Epub 2012 Dec 20 doi: 10.1161/CIRCHEARTFAILURE.112.969717. [Epub ahead of print] PMID: 23258574Free PMC Article
Gesualdo L, London G, Turner M, Lee C, Macdonald K, Goldsmith D, Covic A, Zaoui P, Combe C, Mann J, Dellanna F, Muenzberg M, Abraham I
Intern Emerg Med 2013 Aug;8(5):389-99. Epub 2011 May 18 doi: 10.1007/s11739-011-0622-7. [Epub ahead of print] PMID: 21590439
Chui BK, Pannu N, Hazel M, Dong J, Tonelli M, Klarenbach SW
J Trauma Acute Care Surg 2012 Jul;73(1):195-201. doi: 10.1097/TA.0b013e31824ba1da. PMID: 22710785

Recent systematic reviews

Więcek A, Ahmed I, Scigalla P, Koytchev R
Adv Ther 2010 Dec;27(12):941-52. Epub 2010 Oct 22 doi: 10.1007/s12325-010-0080-z. [Epub ahead of print] PMID: 20972656
Stowell CP, Jones SC, Enny C, Langholff W, Leitz G
Spine (Phila Pa 1976) 2009 Nov 1;34(23):2479-85. doi: 10.1097/BRS.0b013e3181bd163f. PMID: 19927096
Marec-Berard P, Chastagner P, Kassab-Chahmi D, Casadevall N, Marchal C, Misset JL, Ray-Coquard I
Pediatr Blood Cancer 2009 Jul;53(1):7-12. doi: 10.1002/pbc.21953. PMID: 19229970
Kimel M, Leidy NK, Mannix S, Dixon J
Value Health 2008 Jan-Feb;11(1):57-75. doi: 10.1111/j.1524-4733.2007.00215.x. PMID: 18237361
Cremieux PY, Van Audenrode M, Lefebvre P
Curr Med Res Opin 2006 Dec;22(12):2329-36. doi: 10.1185/030079906X154024. PMID: 17257447

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