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1.

Malignant Lung Neoplasm

Lung cancer is one of the most common cancers in the world. It is a leading cause of cancer death in men and women in the United States. Cigarette smoking causes most lung cancers. The more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. High levels of pollution, radiation and asbestos exposure may also increase risk. . Common symptoms of lung cancer include: -A cough that doesn't go away and gets worse over time. -Constant chest pain. -Coughing up blood. -Shortness of breath, wheezing, or hoarseness. -Repeated problems with pneumonia or bronchitis. -Swelling of the neck and face. -Loss of appetite or weight loss. -Fatigue. There are many types of lung cancer. Each type of lung cancer grows and spreads in different ways and is treated differently. Treatment also depends on the stage, or how advanced it is. Treatment may include chemotherapy, radiation and surgery. NIH: National Cancer Institute.  [from MedlinePlus]

MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
2.

Secretin

A hormone released into the blood by cells in the inner layer of the small intestine. It is released when partly digested food moves from the stomach into the small intestine. Secretin causes the pancreas, liver, and stomach to release other substances that help digest food. Secretin may also be made in the laboratory. [from NCI]

MedGen UID:
48601
Concept ID:
C0036534
Pharmacologic Substance
3.

Carcinoid

A tumor formed from the endocrine (argentaffin) cells of the mucosal lining of a variety of organs including the stomach and intestine. These cells are from neuroectodermal origin. [from HPO]

MedGen UID:
506485
Concept ID:
CN117463
Finding
4.

Spondylometaepiphyseal dysplasia short limb-hand type

MedGen UID:
338595
Concept ID:
C1849011
Disease or Syndrome
5.

Lung cancer

Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008). [from OMIM]

MedGen UID:
195765
Concept ID:
C0684249
Neoplastic Process
6.

Somatostatin

Expressed primarily by human SST Gene (Somatostatin Family) in the hypothalamic median eminence and in pancreatic delta cells, secreted 116-aa 13-kDa (precursor) Somatostatin is an important cyclic tetradecapeptide regulator of endocrine and nervous system function. Somatostatin inhibits release of adenohypophyseal GH, thyrotropin, and corticotropin, pancreatic insulin and glucagon, gastric mucosal gastrin, intestinal mucosal secretin, and renal renin by binding to specific high-affinity cell surface G protein-coupled receptors expressed in a tissue-specific manner. (NCI) [from NCI]

MedGen UID:
11505
Concept ID:
C0037659
Pharmacologic Substance
7.

Diagnosis

The process of identifying a disease, such as cancer, from its signs and symptoms. [from NCI]

MedGen UID:
8354
Concept ID:
C0011900
Finding
8.

Inflammation

A microscopic finding indicating the presence of acute, subacute or chronic inflammation in a tissue sample. [from NCI]

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
9.

Moderate

Indicates the condition may result in noticable adverse adverse consequences but is unlikely to be life-threatening or cause permanent injury.  [from HL7]

MedGen UID:
525853
Concept ID:
C0205081
10.

Functional disorder

Deranged function in an individual or an organ that is due to a disease. (MedicineNet.com) [from NCI]

MedGen UID:
124450
Concept ID:
C0277785
Pathologic Function
11.

Acute inflammation

A morphologic finding indicating the presence of neutrophils and/or eosinophils in a tissue sample. [from NCI]

MedGen UID:
87166
Concept ID:
C0333361
Finding
12.

Acute

Symptoms or signs that begin and worsen quickly; not chronic. [from NCI]

MedGen UID:
61381
Concept ID:
C0205178
13.

Epithelial Neoplasm

neoplasm of epithelial origin, ranging from benign (adenoma and papilloma) to malignant (carcinoma). [from CRISP]

MedGen UID:
277963
Concept ID:
C1368683
Neoplastic Process
14.

Cancer, Embryonal

MedGen UID:
199639
Concept ID:
C0751364
Neoplastic Process
15.

Carcinoid Tumor of Uncertain Malignant Potential

A carcinoid tumor that shows atypical characteristics and has borderline malignant potential. [from NCI]

MedGen UID:
109014
Concept ID:
C0600176
Neoplastic Process
16.

Carcinomatosis

A condition in which cancer is spread widely throughout the body. [from NCI]

MedGen UID:
104704
Concept ID:
C0205699
Neoplastic Process
17.

Cribriform Carcinoma

A carcinoma characterized by the presence of a cribriform architectural pattern. Representative examples include the intraductal cribriform breast carcinoma and invasive cribriform breast carcinoma. [from NCI]

MedGen UID:
104694
Concept ID:
C0205643
Neoplastic Process
18.

Small Cell Carcinoma

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7) [from MeSH]

MedGen UID:
82650
Concept ID:
C0262584
Neoplastic Process
19.

Neuroendocrine neoplasm

Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition. [from MeSH]

MedGen UID:
64652
Concept ID:
C0206754
Neoplastic Process
20.

Tubular Adenocarcinoma

A malignant glandular neoplasm exhibiting tubular structures. [from NCI]

MedGen UID:
61428
Concept ID:
C0205645
Neoplastic Process

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