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Results: 9

1.

Serine

A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04) [from NCI]

MedGen UID:
11382
Concept ID:
C0036720
Pharmacologic Substance
2.

Trypsin

A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4. [from MeSH]

MedGen UID:
21715
Concept ID:
C0041236
Pharmacologic Substance
3.

Protein-Protein Interaction

Temporary, non-covalent binding between protein molecules. Protein-protein interactions occur as a result of intermolecular physical forces and spatial complementation between domains or motifs. This interaction can be either homotypic or heterotypic and effect protein structure, conformation, and function. [from NCI]

MedGen UID:
209050
Concept ID:
C0872079
Molecular Function
4.

Recruitment

MedGen UID:
78772
Concept ID:
C0271510
Disease or Syndrome
5.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
6.

Endopeptidases

nonEC category which corresponds to EC 3.4.21, EC 3.4.22, EC 3.4.23, EC 3.4.24, and EC 3.4.99. [from CRISP]

MedGen UID:
45389
Concept ID:
C0030946
Pharmacologic Substance
7.

Serine Proteinase Inhibitors

Compounds that inhibit serine endopeptidases. Serine proteinase inhibitors can be either exogenous or endogenous. Endogenous moieties occur naturally; however, exogenous inhibitors can be introduced to provide therapeutic benefit, such as antiretroviral or antiviral pharmaceuticals. [from NCI]

MedGen UID:
20708
Concept ID:
C0036733
Pharmacologic Substance
8.

Protease Inhibitor

A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies of itself (for example, AIDS virus protease inhibitors), and some can prevent cancer cells from spreading. [from NCI]

MedGen UID:
18701
Concept ID:
C0033607
Pharmacologic Substance
9.

Enzyme Inhibitors

compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from CRISP]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance

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