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Mesothelioma

MedGen UID:
9975
Concept ID:
C0025500
Neoplastic Process
Synonyms: Mesothelioma, somatic
SNOMED CT: Mesothelioma (62064005); Mesothelial neoplasm (115232000)
 
Orphanet: ORPHA50251

Definition

The tissue that lines your lungs, stomach, heart, and other organs is called mesothelium. Mesothelioma is a tumor of that tissue. It usually starts in the lungs, but can also start in the abdomen or other organs. It can be benign (not cancer) or malignant (cancer.). Malignant mesothelioma is a rare but serious type of cancer. Most people who get it have worked on jobs where they inhaled asbestos particles. After being exposed to asbestos, it usually takes a long time for the disease to form. Symptoms include. -Trouble breathing. -Pain under the rib cage. -Pain, swelling, or lumps in the abdomen. -Weight loss for no known reason. Sometimes it is hard to tell the difference between malignant mesothelioma and lung cancer. Your doctor uses imaging tests and a biopsy to make the diagnosis. Malignant mesothelioma is often found when it is advanced. This makes it harder to treat. Treatment may include surgery, radiation, and/or chemotherapy. NIH: National Cancer Institute.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesothelioma
Follow this link to review classifications for Mesothelioma in Orphanet.

Recent clinical studies

Etiology

Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-14. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. [Epub ahead of print] PMID: 26719230
Lambert CS, Alexander BH, Ramachandran G, MacLehose RF, Nelson HH, Ryan AD, Mandel JH
Occup Environ Med 2016 Feb;73(2):103-9. Epub 2015 Dec 10 doi: 10.1136/oemed-2015-103105. [Epub ahead of print] PMID: 26655961
Stahel RA, Riesterer O, Xyrafas A, Opitz I, Beyeler M, Ochsenbein A, Früh M, Cathomas R, Nackaerts K, Peters S, Mamot C, Zippelius A, Mordasini C, Caspar CB, Eckhardt K, Schmid RA, Aebersold DM, Gautschi O, Nagel W, Töpfer M, Krayenbuehl J, Ribi K, Ciernik LF, Weder W
Lancet Oncol 2015 Dec;16(16):1651-8. Epub 2015 Nov 2 doi: 10.1016/S1470-2045(15)00208-9. [Epub ahead of print] PMID: 26538423
Pavlisko EN, Roggli VL
Am J Surg Pathol 2015 Nov;39(11):1568-75. doi: 10.1097/PAS.0000000000000495. PMID: 26371785
Hjerpe A, Ascoli V, Bedrossian CW, Boon ME, Creaney J, Davidson B, Dejmek A, Dobra K, Fassina A, Field A, Firat P, Kamei T, Kobayashi T, Michael CW, Önder S, Segal A, Vielh P; International Mesothelioma Interest Group; International Academy of Cytology
Diagn Cytopathol 2015 Jul;43(7):563-76. doi: 10.1002/dc.23271. PMID: 26100969

Diagnosis

Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-14. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. [Epub ahead of print] PMID: 26719230
Hwang HC, Sheffield BS, Rodriguez S, Thompson K, Tse CH, Gown AM, Churg A
Am J Surg Pathol 2016 Jan;40(1):120-6. doi: 10.1097/PAS.0000000000000529. PMID: 26448191
Cheung M, Kadariya Y, Pei J, Talarchek J, Facciolo F, Visca P, Righi L, Cozzi I, Testa JR, Ascoli V
Cancer Genet 2015 Oct;208(10):502-7. Epub 2015 Jul 30 doi: 10.1016/j.cancergen.2015.07.004. [Epub ahead of print] PMID: 26364129Free PMC Article
Stephens RJ, Whiting C, Cowan K; James Lind Alliance Mesothelioma Priority Setting Partnership Steering Committee
Lung Cancer 2015 Aug;89(2):175-80. Epub 2015 Jun 4 doi: 10.1016/j.lungcan.2015.05.021. [Epub ahead of print] PMID: 26115838
Hjerpe A, Ascoli V, Bedrossian CW, Boon ME, Creaney J, Davidson B, Dejmek A, Dobra K, Fassina A, Field A, Firat P, Kamei T, Kobayashi T, Michael CW, Önder S, Segal A, Vielh P; International Mesothelioma Interest Group; International Academy of Cytology
Diagn Cytopathol 2015 Jul;43(7):563-76. doi: 10.1002/dc.23271. PMID: 26100969

Therapy

Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-14. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. [Epub ahead of print] PMID: 26719230
Lambert CS, Alexander BH, Ramachandran G, MacLehose RF, Nelson HH, Ryan AD, Mandel JH
Occup Environ Med 2016 Feb;73(2):103-9. Epub 2015 Dec 10 doi: 10.1136/oemed-2015-103105. [Epub ahead of print] PMID: 26655961
Stahel RA, Riesterer O, Xyrafas A, Opitz I, Beyeler M, Ochsenbein A, Früh M, Cathomas R, Nackaerts K, Peters S, Mamot C, Zippelius A, Mordasini C, Caspar CB, Eckhardt K, Schmid RA, Aebersold DM, Gautschi O, Nagel W, Töpfer M, Krayenbuehl J, Ribi K, Ciernik LF, Weder W
Lancet Oncol 2015 Dec;16(16):1651-8. Epub 2015 Nov 2 doi: 10.1016/S1470-2045(15)00208-9. [Epub ahead of print] PMID: 26538423
Marcq E, Pauwels P, van Meerbeeck JP, Smits EL
Cancer Treat Rev 2015 Dec;41(10):914-24. Epub 2015 Sep 28 doi: 10.1016/j.ctrv.2015.09.006. [Epub ahead of print] PMID: 26433514
Cheung M, Kadariya Y, Pei J, Talarchek J, Facciolo F, Visca P, Righi L, Cozzi I, Testa JR, Ascoli V
Cancer Genet 2015 Oct;208(10):502-7. Epub 2015 Jul 30 doi: 10.1016/j.cancergen.2015.07.004. [Epub ahead of print] PMID: 26364129Free PMC Article

Prognosis

Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-14. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. [Epub ahead of print] PMID: 26719230
Hwang HC, Sheffield BS, Rodriguez S, Thompson K, Tse CH, Gown AM, Churg A
Am J Surg Pathol 2016 Jan;40(1):120-6. doi: 10.1097/PAS.0000000000000529. PMID: 26448191
Pavlisko EN, Roggli VL
Am J Surg Pathol 2015 Nov;39(11):1568-75. doi: 10.1097/PAS.0000000000000495. PMID: 26371785
Vavougios GD, Solenov EI, Hatzoglou C, Baturina GS, Katkova LE, Molyvdas PA, Gourgoulianis KI, Zarogiannis SG
Am J Physiol Lung Cell Mol Physiol 2015 Oct 1;309(7):L677-86. Epub 2015 Aug 7 doi: 10.1152/ajplung.00051.2015. [Epub ahead of print] PMID: 26254420
Damhuis RA, Khakwani A, De Schutter H, Rich AL, Burgers JA, van Meerbeeck JP
Lung Cancer 2015 Aug;89(2):212-7. Epub 2015 May 22 doi: 10.1016/j.lungcan.2015.05.014. [Epub ahead of print] PMID: 26044908

Clinical prediction guides

Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-14. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. [Epub ahead of print] PMID: 26719230
Lambert CS, Alexander BH, Ramachandran G, MacLehose RF, Nelson HH, Ryan AD, Mandel JH
Occup Environ Med 2016 Feb;73(2):103-9. Epub 2015 Dec 10 doi: 10.1136/oemed-2015-103105. [Epub ahead of print] PMID: 26655961
Hwang HC, Sheffield BS, Rodriguez S, Thompson K, Tse CH, Gown AM, Churg A
Am J Surg Pathol 2016 Jan;40(1):120-6. doi: 10.1097/PAS.0000000000000529. PMID: 26448191
Pavlisko EN, Roggli VL
Am J Surg Pathol 2015 Nov;39(11):1568-75. doi: 10.1097/PAS.0000000000000495. PMID: 26371785
Bononi A, Napolitano A, Pass HI, Yang H, Carbone M
Expert Rev Respir Med 2015 Oct;9(5):633-54. Epub 2015 Aug 26 doi: 10.1586/17476348.2015.1081066. [Epub ahead of print] PMID: 26308799

Recent systematic reviews

Buikhuisen WA, Hiddinga BI, Baas P, van Meerbeeck JP
Lung Cancer 2015 Sep;89(3):223-31. Epub 2015 Jun 23 doi: 10.1016/j.lungcan.2015.06.018. [Epub ahead of print] PMID: 26162564
Blomberg C, Nilsson J, Holgersson G, Edlund P, Bergqvist M, Adwall L, Ekman S, Brattström D, Bergström S
Anticancer Res 2015 May;35(5):2493-501. PMID: 25964522
Hjerpe A, Ascoli V, Bedrossian CW, Boon ME, Creaney J, Davidson B, Dejmek A, Dobra K, Fassina A, Field A, Firat P, Kamei T, Kobayashi T, Michael CW, Önder S, Segal A, Vielh P; International Mesothelioma Interest Group; International Academy of Cytology; Papanicolaou Society of Cytopathology
Acta Cytol 2015;59(1):2-16. Epub 2015 Mar 24 doi: 10.1159/000377697. [Epub ahead of print] PMID: 25824655
Demirer E, Ghattas CF, Radwan MO, Elamin EM
Yonsei Med J 2015 Mar;56(2):311-23. doi: 10.3349/ymj.2015.56.2.311. PMID: 25683976Free PMC Article
Miller AC, Miettinen M, Schrump DS, Hassan R
Ann Am Thorac Soc 2014 Sep;11(7):1075-81. doi: 10.1513/AnnalsATS.201404-165BC. PMID: 25079105Free PMC Article

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