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Gliosarcoma

MedGen UID:
64638
Concept ID:
C0206726
Neoplastic Process
Synonyms: Glioblastoma with Sarcomatous Component; Glioma, Sarcomatous; Gliomas, Sarcomatous; Gliosarcomas; Sarcomatous Glioma; Sarcomatous Gliomas
SNOMED CT: Gliosarcoma (35262004); Glioblastoma with sarcomatous component (35262004)
 

Definition

Rare mixed tumors of the brain and rarely the spinal cord which contain malignant neuroectodermal (glial) and mesenchymal components, including spindle-shaped fibrosarcoma cells. These tumors are highly aggressive and present primarily in adults as rapidly expanding mass lesions. They may arise in tissue that has been previously irradiated. (From Br J Neurosurg 1995 Apr;9(2):171-8) [from MeSH]

Recent clinical studies

Etiology

Romero-Rojas AE, Diaz-Perez JA, Ariza-Serrano LM, Amaro D, Lozano-Castillo A
Neuroradiol J 2013 Dec;26(6):639-48. Epub 2013 Dec 18 [Epub ahead of print] PMID: 24355182
Walker GV, Gilbert MR, Prabhu SS, Brown PD, McAleer MF
J Neurooncol 2013 Mar;112(1):83-9. Epub 2012 Dec 25 doi: 10.1007/s11060-012-1029-7. [Epub ahead of print] PMID: 23266723
Singh G, Mallick S, Sharma V, Joshi N, Purkait S, Jha P, Sharma MC, Suri V, Julka PK, Mahapatra AK, Singh M, Kale SS, Sarkar C
Neuropathology 2012 Oct;32(5):534-42. Epub 2012 Mar 1 doi: 10.1111/j.1440-1789.2012.01297.x. [Epub ahead of print] PMID: 22380407
Biswas A, Kumar N, Kumar P, Vasishta RK, Gupta K, Sharma SC, Patel F, Mathuriya SN
Br J Neurosurg 2011 Dec;25(6):723-9. Epub 2011 May 18 doi: 10.3109/02688697.2011.570881. [Epub ahead of print] PMID: 21591852
Wang X, Duan X, Yang G, Zhang X, Deng L, Zheng H, Deng C, Wen J, Wang N, Peng C, Zhao X, Wei Y, Chen L
PLoS One 2011 Apr 29;6(4):e18490. doi: 10.1371/journal.pone.0018490. PMID: 21559510Free PMC Article

Diagnosis

Romero-Rojas AE, Diaz-Perez JA, Ariza-Serrano LM, Amaro D, Lozano-Castillo A
Neuroradiol J 2013 Dec;26(6):639-48. Epub 2013 Dec 18 [Epub ahead of print] PMID: 24355182
Walker GV, Gilbert MR, Prabhu SS, Brown PD, McAleer MF
J Neurooncol 2013 Mar;112(1):83-9. Epub 2012 Dec 25 doi: 10.1007/s11060-012-1029-7. [Epub ahead of print] PMID: 23266723
Hiniker A, Hagenkord JM, Powers MP, Aghi MK, Prados MD, Perry A
Clin Neuropathol 2013 May-Jun;32(3):165-70. doi: 10.5414/NP300577. PMID: 23254140
Dawar R, Fabiano AJ, Qiu J, Khushalani NI
Clin Neurol Neurosurg 2013 Apr;115(4):375-80. Epub 2012 Jul 12 doi: 10.1016/j.clineuro.2012.06.017. [Epub ahead of print] PMID: 22795300
Ravisankar S, Chander RV, Devadoss PK
Indian J Pathol Microbiol 2012 Oct-Dec;55(4):521-4. doi: 10.4103/0377-4929.107797. PMID: 23455794

Therapy

Trignani M, Taraborrelli M, Ausili Cèfaro G
Tumori 2013 May-Jun;99(3):e117-9. doi: 10.1700/1334.14818. PMID: 24158079
Walker GV, Gilbert MR, Prabhu SS, Brown PD, McAleer MF
J Neurooncol 2013 Mar;112(1):83-9. Epub 2012 Dec 25 doi: 10.1007/s11060-012-1029-7. [Epub ahead of print] PMID: 23266723
Dawar R, Fabiano AJ, Qiu J, Khushalani NI
Clin Neurol Neurosurg 2013 Apr;115(4):375-80. Epub 2012 Jul 12 doi: 10.1016/j.clineuro.2012.06.017. [Epub ahead of print] PMID: 22795300
Butowski N, Chang SM, Lamborn KR, Polley MY, Pieper R, Costello JF, Vandenberg S, Parvataneni R, Nicole A, Sneed PK, Clarke J, Hsieh E, Costa BM, Reis RM, Hristova-Kazmierski M, Nicol SJ, Thornton DE, Prados MD
Neuro Oncol 2011 Dec;13(12):1331-8. Epub 2011 Sep 6 doi: 10.1093/neuonc/nor130. [Epub ahead of print] PMID: 21896554Free PMC Article
Biswas A, Kumar N, Kumar P, Vasishta RK, Gupta K, Sharma SC, Patel F, Mathuriya SN
Br J Neurosurg 2011 Dec;25(6):723-9. Epub 2011 May 18 doi: 10.3109/02688697.2011.570881. [Epub ahead of print] PMID: 21591852

Prognosis

Trignani M, Taraborrelli M, Ausili Cèfaro G
Tumori 2013 May-Jun;99(3):e117-9. doi: 10.1700/1334.14818. PMID: 24158079
Dawar R, Fabiano AJ, Qiu J, Khushalani NI
Clin Neurol Neurosurg 2013 Apr;115(4):375-80. Epub 2012 Jul 12 doi: 10.1016/j.clineuro.2012.06.017. [Epub ahead of print] PMID: 22795300
Ravisankar S, Chander RV, Devadoss PK
Indian J Pathol Microbiol 2012 Oct-Dec;55(4):521-4. doi: 10.4103/0377-4929.107797. PMID: 23455794
Singh G, Mallick S, Sharma V, Joshi N, Purkait S, Jha P, Sharma MC, Suri V, Julka PK, Mahapatra AK, Singh M, Kale SS, Sarkar C
Neuropathology 2012 Oct;32(5):534-42. Epub 2012 Mar 1 doi: 10.1111/j.1440-1789.2012.01297.x. [Epub ahead of print] PMID: 22380407
Biswas A, Kumar N, Kumar P, Vasishta RK, Gupta K, Sharma SC, Patel F, Mathuriya SN
Br J Neurosurg 2011 Dec;25(6):723-9. Epub 2011 May 18 doi: 10.3109/02688697.2011.570881. [Epub ahead of print] PMID: 21591852

Clinical prediction guides

Romero-Rojas AE, Diaz-Perez JA, Ariza-Serrano LM, Amaro D, Lozano-Castillo A
Neuroradiol J 2013 Dec;26(6):639-48. Epub 2013 Dec 18 [Epub ahead of print] PMID: 24355182
Singh G, Mallick S, Sharma V, Joshi N, Purkait S, Jha P, Sharma MC, Suri V, Julka PK, Mahapatra AK, Singh M, Kale SS, Sarkar C
Neuropathology 2012 Oct;32(5):534-42. Epub 2012 Mar 1 doi: 10.1111/j.1440-1789.2012.01297.x. [Epub ahead of print] PMID: 22380407
Nagaishi M, Paulus W, Brokinkel B, Vital A, Tanaka Y, Nakazato Y, Giangaspero F, Ohgaki H
Brain Pathol 2012 Sep;22(5):670-6. Epub 2012 Mar 5 doi: 10.1111/j.1750-3639.2012.00571.x. [Epub ahead of print] PMID: 22288519
Butowski N, Chang SM, Lamborn KR, Polley MY, Pieper R, Costello JF, Vandenberg S, Parvataneni R, Nicole A, Sneed PK, Clarke J, Hsieh E, Costa BM, Reis RM, Hristova-Kazmierski M, Nicol SJ, Thornton DE, Prados MD
Neuro Oncol 2011 Dec;13(12):1331-8. Epub 2011 Sep 6 doi: 10.1093/neuonc/nor130. [Epub ahead of print] PMID: 21896554Free PMC Article
Biswas A, Kumar N, Kumar P, Vasishta RK, Gupta K, Sharma SC, Patel F, Mathuriya SN
Br J Neurosurg 2011 Dec;25(6):723-9. Epub 2011 May 18 doi: 10.3109/02688697.2011.570881. [Epub ahead of print] PMID: 21591852

Recent systematic reviews

Han SJ, Yang I, Otero JJ, Ahn BJ, Tihan T, McDermott MW, Berger MS, Chang SM, Parsa AT
J Neurosurg 2010 May;112(5):990-6. doi: 10.3171/2009.9.JNS09931. PMID: 19817543
Karremann M, Rausche U, Fleischhack G, Nathrath M, Pietsch T, Kramm CM, Wolff JE
J Neurooncol 2010 Apr;97(2):257-65. Epub 2009 Oct 6 doi: 10.1007/s11060-009-0021-3. [Epub ahead of print] PMID: 19806321
Salvati M, Lenzi J, Brogna C, Frati A, Piccirilli M, Giangaspero F, Raco A
Childs Nerv Syst 2006 Oct;22(10):1301-6. Epub 2006 Mar 16 doi: 10.1007/s000381-006-0057-z. [Epub ahead of print] PMID: 16541294

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